ES419142A1 - 2-2-2-methyl-5-nitro-1-imidazolyl-ethyl-2-thiopseudoureas and related compounds - Google Patents

2-2-2-methyl-5-nitro-1-imidazolyl-ethyl-2-thiopseudoureas and related compounds

Info

Publication number
ES419142A1
ES419142A1 ES419142A ES419142A ES419142A1 ES 419142 A1 ES419142 A1 ES 419142A1 ES 419142 A ES419142 A ES 419142A ES 419142 A ES419142 A ES 419142A ES 419142 A1 ES419142 A1 ES 419142A1
Authority
ES
Spain
Prior art keywords
formula
hydrogen
ch2ch2x
radical
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES419142A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of ES419142A1 publication Critical patent/ES419142A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C07D233/94—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms

Abstract

Procedure for preparing thioseudourea derivatives, of general formula: **(See formula)** or a pharmaceutically acceptable, non-toxic acid addition salt thereof, in which formula R is hydrogen or an alkyl radical of 1 to 7 carbon atoms, R1 and R'' are each hydrogen or an alkyl radical of 1 at 7 carbon atoms, or R'and R''are combined to form a vinylene, nitrovinylene or trimethylene grouping; characterized by comprising: reacting a compound of the general formula: **(See formula)** where A is hydrogen or a radical of formula -CH2CH2X, where X is halogen, toluenesulfonyloxy or methanesulfonyloxy; with a compound of general formula: **(See formula)** where Z is hydrogen when A is -CH2CH2X; Z is a radical of formula -CH2CH2X when A is hydrogen; and R, R'and R''are defined as above, with the proviso that R' and R'' may combine to form a nitrovinylene grouping only when Z is -CH2CH2X. (Machine-translation by Google Translate, not legally binding)
ES419142A 1972-09-28 1973-09-27 2-2-2-methyl-5-nitro-1-imidazolyl-ethyl-2-thiopseudoureas and related compounds Expired ES419142A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29306972A 1972-09-28 1972-09-28

Publications (1)

Publication Number Publication Date
ES419142A1 true ES419142A1 (en) 1976-07-16

Family

ID=23127520

Family Applications (1)

Application Number Title Priority Date Filing Date
ES419142A Expired ES419142A1 (en) 1972-09-28 1973-09-27 2-2-2-methyl-5-nitro-1-imidazolyl-ethyl-2-thiopseudoureas and related compounds

Country Status (10)

Country Link
JP (1) JPS4970967A (en)
AR (1) AR197529A1 (en)
AU (1) AU473626B2 (en)
BE (1) BE805432A (en)
CA (1) CA967961A (en)
DE (1) DE2348525A1 (en)
ES (1) ES419142A1 (en)
FR (1) FR2201094B1 (en)
GB (1) GB1393228A (en)
ZA (1) ZA737629B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1542840A (en) * 1975-02-03 1979-03-28 Smith Kline French Lab Heterocyclic dithiocarbamates and isothioureas
USRE34201E (en) * 1989-04-20 1993-03-23 Anaquest, Inc. N-aryl-N-[4-(1-heterocyclicalkyl)piperidinyl]amides and pharmaceutical compositions and methods employing such compounds
JPH0717971A (en) * 1993-07-02 1995-01-20 Takeda Chem Ind Ltd Imidazole derivative, production and use thereof
WO2020201096A1 (en) 2019-03-29 2020-10-08 Université de Paris Imidazoline derivatives as cxcr4 modulators

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1277666A (en) * 1969-12-17 1972-06-14 Pfizer Ltd Improvements in the n-alkylation of nitroimidazoles

Also Published As

Publication number Publication date
AU6081473A (en) 1975-03-27
AU473626B2 (en) 1976-06-24
AR197529A1 (en) 1974-04-15
DE2348525A1 (en) 1974-04-11
GB1393228A (en) 1975-05-07
FR2201094A1 (en) 1974-04-26
BE805432A (en) 1974-03-28
JPS4970967A (en) 1974-07-09
FR2201094B1 (en) 1977-01-28
CA967961A (en) 1975-05-20
ZA737629B (en) 1974-12-24

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