ES406768A1 - Procedure for the preparation of new indol derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of new indol derivatives. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES406768A1
ES406768A1 ES406768A ES406768A ES406768A1 ES 406768 A1 ES406768 A1 ES 406768A1 ES 406768 A ES406768 A ES 406768A ES 406768 A ES406768 A ES 406768A ES 406768 A1 ES406768 A1 ES 406768A1
Authority
ES
Spain
Prior art keywords
hydrogen
general formula
aralcohyl
alcohol
lower alcohol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES406768A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Terapeutisk Laboratorium AS
Original Assignee
Novo Terapeutisk Laboratorium AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Terapeutisk Laboratorium AS filed Critical Novo Terapeutisk Laboratorium AS
Publication of ES406768A1 publication Critical patent/ES406768A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedure for the preparation of new indole derivatives of the general formula I. ** (See formula) ** wherein X and Y independently of one another represent hydrogen, halogen, lower alcohol or lower alkoxy; R1 signifies hydrogen, lower alcohol or lower aralcohyl; R2 signifies hydrogen, lower alcohol, lower aralcohyl or aryl; R3 and R4, independently of each other, represent hydrogen, lower alcohol or lower aralkohyl, or R3 and R4 together with the nitrogen atom attached to them, form a pyrrolidine or piperidine ring; and A is a straight or branched alcohol chain with 2 to 4 carbon atoms, with the proviso that R2 must be hydrogen when R1 is different from hydrogen, and of acid addition salts of these compounds with physiologically tolerable acids, characterized by that an indole derivative of the general formula II is reacted. ** (See formula) ** where X, Y, R2 and A are as defined above, Z means a halogen atom and R5 means lower alkanoyl, lower alcohol or lower aralcohyl, with the proviso that R2 must be hydrogen when R5 is lower alcohol or aralcohyl lower, with a compound of the general formula III ** (See formula) ** where R3 and R4 are as defined above, or with an acid addition salt thereof, where when starting from a compound of the general formula II in which R5 is lower alkanoyl, it is transformed into a compound of the general formula I where R1 is hydrogen. (Machine-translation by Google Translate, not legally binding)
ES406768A 1969-05-27 1972-09-16 Procedure for the preparation of new indol derivatives. (Machine-translation by Google Translate, not legally binding) Expired ES406768A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2668369 1969-05-27

Publications (1)

Publication Number Publication Date
ES406768A1 true ES406768A1 (en) 1975-10-01

Family

ID=10247535

Family Applications (3)

Application Number Title Priority Date Filing Date
ES380057A Expired ES380057A1 (en) 1969-05-27 1970-05-26 Procedure for the preparation of new indol derivatives. (Machine-translation by Google Translate, not legally binding)
ES406768A Expired ES406768A1 (en) 1969-05-27 1972-09-16 Procedure for the preparation of new indol derivatives. (Machine-translation by Google Translate, not legally binding)
ES406767A Expired ES406767A1 (en) 1969-05-27 1972-09-16 Procedure for the preparation of new indol derivatives. (Machine-translation by Google Translate, not legally binding)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES380057A Expired ES380057A1 (en) 1969-05-27 1970-05-26 Procedure for the preparation of new indol derivatives. (Machine-translation by Google Translate, not legally binding)

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES406767A Expired ES406767A1 (en) 1969-05-27 1972-09-16 Procedure for the preparation of new indol derivatives. (Machine-translation by Google Translate, not legally binding)

Country Status (11)

Country Link
AT (3) AT315830B (en)
AU (1) AU1535270A (en)
BE (1) BE750943A (en)
CA (1) CA966137A (en)
CH (1) CH556840A (en)
DE (2) DE2024966A1 (en)
ES (3) ES380057A1 (en)
FR (1) FR2051562B1 (en)
GB (1) GB1306230A (en)
NL (1) NL7007646A (en)
ZA (1) ZA703363B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9416972D0 (en) * 1994-08-23 1994-10-12 Smithkline Beecham Plc Carbon side chain/indole/indolene
CN1720227A (en) * 2002-11-28 2006-01-11 苏文生命科学有限公司 N-arylsulfonyl-3-aminoalkoxyindoles
WO2004048331A1 (en) * 2002-11-28 2004-06-10 Suven Life Sciences Limited N-arylalkyl-3-aminoalkoxyindoles and their use as 5-ht ligands

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2395370A (en) * 1970-12-31 1972-07-06 Novo Terapeutisk Laboratorium A/S Improvements in or relating to indole derivatives

Also Published As

Publication number Publication date
CA966137A (en) 1975-04-15
BE750943A (en) 1970-11-26
FR2051562B1 (en) 1974-07-12
DE2024966A1 (en) 1970-12-03
FR2051562A1 (en) 1971-04-09
AU1535270A (en) 1971-11-25
AT315830B (en) 1974-06-10
ES406767A1 (en) 1975-10-01
AT307410B (en) 1973-05-25
NL7007646A (en) 1970-12-01
ZA703363B (en) 1971-12-29
AT312596B (en) 1974-01-10
CH556840A (en) 1974-12-13
GB1306230A (en) 1973-02-07
DE2065321A1 (en) 1973-05-24
ES380057A1 (en) 1973-04-16

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