ES380057A1 - Procedure for the preparation of new indol derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of new indol derivatives. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES380057A1
ES380057A1 ES380057A ES380057A ES380057A1 ES 380057 A1 ES380057 A1 ES 380057A1 ES 380057 A ES380057 A ES 380057A ES 380057 A ES380057 A ES 380057A ES 380057 A1 ES380057 A1 ES 380057A1
Authority
ES
Spain
Prior art keywords
hydrogen
lower alcohol
alcohol
formula
translation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES380057A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Terapeutisk Laboratorium AS
Original Assignee
Novo Terapeutisk Laboratorium AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Terapeutisk Laboratorium AS filed Critical Novo Terapeutisk Laboratorium AS
Publication of ES380057A1 publication Critical patent/ES380057A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedure for the preparation of new indole derivatives of the general formula ** (See formula) ** where X is hydrogen, lower alcohol, hydroxy or lower alkoxy, X is hydrogen, lower alcohol, hydroxy or lower alkoxy, R1 is hydrogen, lower alcohol or lower aralkohyl, R2 is hydrogen, lower alcohol, aryl or lower aralkohyl, R3 is hydrogen or R6 (R6 represents lower alcohol, cycloalkyl or lower aralkohyl where the aryl group may be substituted) and A means a straight or branched alcohol chain with 2 to 4 carbon atoms, or salts of these compounds with physiologically tolerable acids, characterized why indole derivatives of the general formula undergo appropriate hydrogenolysis ** (See formula) ** where X1 is hydrogen, lower alcohol, lower alkoxy or benzyloxy, Y1 is hydrogen, lower alcohol, lower alkoxy or benzyloxy, R1, R2 and A are as defined above, R4 is an optionally substituted benzyl group, which can be removed by hydrolysis, and R5 signifies hydrogen or R6 (R6 represents lower alcohol, cycloalkoxy or lower aralkoxy, where the aryl group may be substituted), after which the compound of formula I formed, in which R3 is hydrogen, is transformed, if desired, into a compound of formula (I) in which R3 represents R6, and because the compounds of general formula I obtained are transformed, if desired, with physiologically tolerable acids, into their salts by the addition of acid. (Machine-translation by Google Translate, not legally binding)
ES380057A 1969-05-27 1970-05-26 Procedure for the preparation of new indol derivatives. (Machine-translation by Google Translate, not legally binding) Expired ES380057A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2668369 1969-05-27

Publications (1)

Publication Number Publication Date
ES380057A1 true ES380057A1 (en) 1973-04-16

Family

ID=10247535

Family Applications (3)

Application Number Title Priority Date Filing Date
ES380057A Expired ES380057A1 (en) 1969-05-27 1970-05-26 Procedure for the preparation of new indol derivatives. (Machine-translation by Google Translate, not legally binding)
ES406768A Expired ES406768A1 (en) 1969-05-27 1972-09-16 Procedure for the preparation of new indol derivatives. (Machine-translation by Google Translate, not legally binding)
ES406767A Expired ES406767A1 (en) 1969-05-27 1972-09-16 Procedure for the preparation of new indol derivatives. (Machine-translation by Google Translate, not legally binding)

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES406768A Expired ES406768A1 (en) 1969-05-27 1972-09-16 Procedure for the preparation of new indol derivatives. (Machine-translation by Google Translate, not legally binding)
ES406767A Expired ES406767A1 (en) 1969-05-27 1972-09-16 Procedure for the preparation of new indol derivatives. (Machine-translation by Google Translate, not legally binding)

Country Status (11)

Country Link
AT (3) AT315830B (en)
AU (1) AU1535270A (en)
BE (1) BE750943A (en)
CA (1) CA966137A (en)
CH (1) CH556840A (en)
DE (2) DE2065321A1 (en)
ES (3) ES380057A1 (en)
FR (1) FR2051562B1 (en)
GB (1) GB1306230A (en)
NL (1) NL7007646A (en)
ZA (1) ZA703363B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9416972D0 (en) * 1994-08-23 1994-10-12 Smithkline Beecham Plc Carbon side chain/indole/indolene
EP1567492B1 (en) * 2002-11-28 2013-05-22 Suven Life Sciences Limited N-arylsulfonyl-3-aminoalkoxyindoles
WO2004048331A1 (en) * 2002-11-28 2004-06-10 Suven Life Sciences Limited N-arylalkyl-3-aminoalkoxyindoles and their use as 5-ht ligands

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2395370A (en) * 1970-12-31 1972-07-06 Novo Terapeutisk Laboratorium A/S Improvements in or relating to indole derivatives

Also Published As

Publication number Publication date
DE2024966A1 (en) 1970-12-03
AT315830B (en) 1974-06-10
ZA703363B (en) 1971-12-29
AT312596B (en) 1974-01-10
NL7007646A (en) 1970-12-01
AT307410B (en) 1973-05-25
DE2065321A1 (en) 1973-05-24
GB1306230A (en) 1973-02-07
CH556840A (en) 1974-12-13
FR2051562B1 (en) 1974-07-12
BE750943A (en) 1970-11-26
FR2051562A1 (en) 1971-04-09
AU1535270A (en) 1971-11-25
ES406767A1 (en) 1975-10-01
CA966137A (en) 1975-04-15
ES406768A1 (en) 1975-10-01

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