ES371373A1 - Procedure for the obtaining of substitute 4-oxo-3-amino-3,4-dihydrotean (3,2-d) pyrimidine derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the obtaining of substitute 4-oxo-3-amino-3,4-dihydrotean (3,2-d) pyrimidine derivatives. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES371373A1 ES371373A1 ES371373A ES371373A ES371373A1 ES 371373 A1 ES371373 A1 ES 371373A1 ES 371373 A ES371373 A ES 371373A ES 371373 A ES371373 A ES 371373A ES 371373 A1 ES371373 A1 ES 371373A1
- Authority
- ES
- Spain
- Prior art keywords
- general formula
- procedure
- radicals
- links
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Procedure for obtaining 4-oxo-3-amino-3,4-dihydro-thieno [3,2-d] pyrimidine derivatives, with the general formula **(See formula)** wherein R1 and R2 represent hydrogen, aryl radicals with or without branches, aryl or heteroaryl radicals, with or without additional substituents, or, together, a polymethylene chain with three to six links, or a heterocarbon chain also with three to six links, with oxygen, sulfur or nitrogen as heteroatoms; R3 and R4 represent hydrogen, straight or branched chain alkyl radicals, from one to seven carbon atoms, with or without additional functional groups, or together, they form with the nitrogen atom that supports them a new cycle of four to seven links, which, in certain cases, can include a second heteroatom; and R5 represents, as the case may be, hydrogen, simple alkyl radicals that can carry an oxygenated or nitrogen function, or aryl or heteroaryl radicals, with or without additional substituents. As well as the physiologically acceptable salts of these compounds. The procedure is characterized in that a compound having the general formula **(See formula)** Where R1 and R2 have the same meaning as before and R is a simple alkyl moiety, it is reacted with an acid of general formula R5-C00H in which R5 has the aforementioned meaning, or with a suitable derivative thereof, such as the corresponding anhydride or halide, under the usual conditions of formation of amides, so that the compounds obtained, of general formula **(See formula)** in which R1 R2, R5 and R have the aforementioned significance, they are finally reacted with hydrazines of the general formula **(See formula)** wherein R3 and R4 have the same meaning as indicated above, and if so desired, the obtained compound is converted to a salt. (Machine-translation by Google Translate, not legally binding)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES371373A ES371373A1 (en) | 1969-09-10 | 1969-09-10 | Procedure for the obtaining of substitute 4-oxo-3-amino-3,4-dihydrotean (3,2-d) pyrimidine derivatives. (Machine-translation by Google Translate, not legally binding) |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES371373A ES371373A1 (en) | 1969-09-10 | 1969-09-10 | Procedure for the obtaining of substitute 4-oxo-3-amino-3,4-dihydrotean (3,2-d) pyrimidine derivatives. (Machine-translation by Google Translate, not legally binding) |
Publications (1)
Publication Number | Publication Date |
---|---|
ES371373A1 true ES371373A1 (en) | 1972-04-01 |
Family
ID=8453828
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES371373A Expired ES371373A1 (en) | 1969-09-10 | 1969-09-10 | Procedure for the obtaining of substitute 4-oxo-3-amino-3,4-dihydrotean (3,2-d) pyrimidine derivatives. (Machine-translation by Google Translate, not legally binding) |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES371373A1 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2200607A1 (en) * | 2007-09-10 | 2010-06-30 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
US20100305200A1 (en) * | 2007-12-12 | 2010-12-02 | Gonul Velicelebi | Compounds that modulate intracellular calcium |
US20110065724A1 (en) * | 2009-09-16 | 2011-03-17 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
US9079891B2 (en) | 2010-08-27 | 2015-07-14 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
US9512116B2 (en) | 2012-10-12 | 2016-12-06 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
-
1969
- 1969-09-10 ES ES371373A patent/ES371373A1/en not_active Expired
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2200607A1 (en) * | 2007-09-10 | 2010-06-30 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
EP2200607A4 (en) * | 2007-09-10 | 2012-02-22 | Calcimedica Inc | Compounds that modulate intracellular calcium |
US8263641B2 (en) | 2007-09-10 | 2012-09-11 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
US8524765B2 (en) | 2007-09-10 | 2013-09-03 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
US20100305200A1 (en) * | 2007-12-12 | 2010-12-02 | Gonul Velicelebi | Compounds that modulate intracellular calcium |
US8389567B2 (en) * | 2007-12-12 | 2013-03-05 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
US20110065724A1 (en) * | 2009-09-16 | 2011-03-17 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
US8618307B2 (en) * | 2009-09-16 | 2013-12-31 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
US9079891B2 (en) | 2010-08-27 | 2015-07-14 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
US10336738B2 (en) | 2010-08-27 | 2019-07-02 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
US9512116B2 (en) | 2012-10-12 | 2016-12-06 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
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