ES371373A1 - Procedure for the obtaining of substitute 4-oxo-3-amino-3,4-dihydrotean (3,2-d) pyrimidine derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for obtaining 4-oxo-3-amino-3,4-dihydro-thieno [3,2-d] pyrimidine derivatives, with the general formula **(See formula)** wherein R1 and R2 represent hydrogen, aryl radicals with or without branches, aryl or heteroaryl radicals, with or without additional substituents, or, together, a polymethylene chain with three to six links, or a heterocarbon chain also with three to six links, with oxygen, sulfur or nitrogen as heteroatoms; R3 and R4 represent hydrogen, straight or branched chain alkyl radicals, from one to seven carbon atoms, with or without additional functional groups, or together, they form with the nitrogen atom that supports them a new cycle of four to seven links, which, in certain cases, can include a second heteroatom; and R5 represents, as the case may be, hydrogen, simple alkyl radicals that can carry an oxygenated or nitrogen function, or aryl or heteroaryl radicals, with or without additional substituents. As well as the physiologically acceptable salts of these compounds. The procedure is characterized in that a compound having the general formula **(See formula)** Where R1 and R2 have the same meaning as before and R is a simple alkyl moiety, it is reacted with an acid of general formula R5-C00H in which R5 has the aforementioned meaning, or with a suitable derivative thereof, such as the corresponding anhydride or halide, under the usual conditions of formation of amides, so that the compounds obtained, of general formula **(See formula)** in which R1 R2, R5 and R have the aforementioned significance, they are finally reacted with hydrazines of the general formula **(See formula)** wherein R3 and R4 have the same meaning as indicated above, and if so desired, the obtained compound is converted to a salt. (Machine-translation by Google Translate, not legally binding)