ES369751A1 - Procedure for the preparation of new indol derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of new indol derivatives. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES369751A1
ES369751A1 ES369751A ES369751A ES369751A1 ES 369751 A1 ES369751 A1 ES 369751A1 ES 369751 A ES369751 A ES 369751A ES 369751 A ES369751 A ES 369751A ES 369751 A1 ES369751 A1 ES 369751A1
Authority
ES
Spain
Prior art keywords
group
general formula
carbon atoms
translation
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES369751A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
JR Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JR Geigy AG filed Critical JR Geigy AG
Publication of ES369751A1 publication Critical patent/ES369751A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedure for the preparation of new indole derivatives of the general formula I **(See formula)** in which one of the symbols R1 and R2 denotes hydrogen, chlorine, the methyl or methoxy group and the other denotes hydrogen, or both together the methylenedioxy group, and R3 and R4 each mean an alkyl group with 4 carbon atoms at most, or together with the adjacent nitrogen atom as -NR3R4, the 1-pyrrolidinyl or piperidine group, R6 means hydrogen, chlorine, the methyl group or a lower alkoxy group with at most 3 carbon atoms and R6 means an alkyl, alkenyl or alkynyl group with 3 carbon atoms at most each time and saturated bond position, and its addition salts with inorganic and organic acids, characterized in that a compound of the general formula II **(See formula)** in which Z means a halogen atom, a lower alkanesulfonyloxy or arenesulfonyloxy group, R1, R2, R5 and R6 have the significance indicated above, it is reacted with an amine of the general formula III **(See formula)** in which R3 and R4 or -NR3R5 have the significance indicated above, and if desired, an indole derivative obtained from the general formula I is transformed into an addition salt with an inorganic or organic acid. (Machine-translation by Google Translate, not legally binding)
ES369751A 1969-07-11 1969-07-22 Procedure for the preparation of new indol derivatives. (Machine-translation by Google Translate, not legally binding) Expired ES369751A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1063369A CH511840A (en) 1969-07-11 1969-07-11 Analgesic 2-benzoyl-indole derivs

Publications (1)

Publication Number Publication Date
ES369751A1 true ES369751A1 (en) 1971-04-01

Family

ID=4365256

Family Applications (1)

Application Number Title Priority Date Filing Date
ES369751A Expired ES369751A1 (en) 1969-07-11 1969-07-22 Procedure for the preparation of new indol derivatives. (Machine-translation by Google Translate, not legally binding)

Country Status (2)

Country Link
CH (2) CH511841A (en)
ES (1) ES369751A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6069153A (en) * 1998-05-12 2000-05-30 American Home Products Corporation Indenoindoles and benzocarbazoles as estrogenic agents
US6479535B1 (en) 1998-05-15 2002-11-12 Wyeth 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations
US6159959A (en) * 1999-05-06 2000-12-12 American Home Products Corporation Combined estrogen and antiestrogen therapy

Also Published As

Publication number Publication date
CH511840A (en) 1971-08-31
CH511841A (en) 1971-08-31

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