ES284864A1 - A procedure for the preparation of difenylmetholic ether basically replaced (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

A process for the preparation of substantially substituted diphenyl methyl ethers of the general formula I ** (See formula) ** where R and R1 represent hydrogen, halogen, hydroxyl or an alkyl or alkoxy group with, at most, three carbon atoms, R2 represents hydrogen or methyl, and R4 and R5 represent hydrogen or the methoxy group, as well as their addition salts with physiologically acceptable acids, characterized in that an amine of the general formula II ** (See formula) ** where R and R1 represent hydrogen, halogen, hydroxyl or an alkyl or alkoxy group with, at most, three carbon atoms, or the benzyloxy group, is condensed with a phenylacetone compound which, in the phenyl nucleus, can carry one or two methoxy groups and, simultaneously or subsequently, hydrogenated; or an amide of the general formula II is condensed with a compound of 1-phenyl-2-halogen-propane or a compound of 1-phenyl-2-halogen-propane, which in the phenyl nucleus can carry one or two methoxy groups, and a double bond optionally present is hydrogenated; or a halogenated diphenylmethyl ether of the general formula III ** (See formula) ** where R and R1 have the above-indicated significance and Hal represents chlorine, bromine or iodine is reacted, optionally in the presence of a hydrogen halide fixing agent, with a 2-amino-3-phenyl-propane compound which in the nucleus Phenyl can carry one or two methoxy groups; or a benzhydrol compound, whose phenyl radicals carry the R and R1 groups as substituents, these substituents having the aforementioned significance, are reacted with a halogenated amine of the general formula IV ** (See formula) ** where Hal is chlorine, bromine or iodine, R3 is hydrogen, methyl or benzyl, and R4 and R5 are hydrogen or the methoxy group, optionally in the presence of a hydrogen halide fixing agent; or a diphenyl-bromo-methane compound, whose phenyl moieties carry as substituents the groups R and R1 substituents having the aforementioned significance, is reacted with a compound of the general formula V ** (See formula) ** where R3, R4 and R5 have the above indicated significance, optionally in the presence of a hydrogen halide fixing agent; or an acid amide of the general formula VI is reduced ** (See formula) ** where R and R1 to R5 have the significance explained above; or a compound of the general formula I, wherein R and R 1 have the above-mentioned significance and R 2 represents hydrogen, is methylated to the nitrogen, after which any remaining O or N-benzyl optionally present are dissociated by hydrogenation and, if desired, the base obtained is transformed with a physiologically acceptable acid into the corresponding addition salt. (Machine-translation by Google Translate, not legally binding)