ES422737A1 - Procedure for the obtaining of heterociclic compounds based on piperazine or homopiperazine. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the obtaining of heterociclic compounds based on piperazine or homopiperazine. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES422737A1
ES422737A1 ES422737A ES422737A ES422737A1 ES 422737 A1 ES422737 A1 ES 422737A1 ES 422737 A ES422737 A ES 422737A ES 422737 A ES422737 A ES 422737A ES 422737 A1 ES422737 A1 ES 422737A1
Authority
ES
Spain
Prior art keywords
general formula
homopiperazine
formula
see formula
signifies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES422737A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ICHTHYOL GES CORDES HERMANNI U
Original Assignee
ICHTHYOL GES CORDES HERMANNI U
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ICHTHYOL GES CORDES HERMANNI U filed Critical ICHTHYOL GES CORDES HERMANNI U
Publication of ES422737A1 publication Critical patent/ES422737A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system

Abstract

Procedure for obtaining piperazine or homopiperazine-based heterocyclic compounds of general formula (I) **(See formula)** where R1 and/or R2 signify hydrogen atoms, lower alkyl or lower alkoxy groups and/or halogen atoms and m represents the number 1 or 2 and where either n represents the number 0, R3 represents a hydrogen atom or a lower alkyl group and R4 signifies an aryl group of the general formula (II) **(See formula)** where R5 and/or R6 signify hydrogen atoms, lower alkyl groups and/or halogen atoms or R5 signifies a hydrogen atom and R6 signifies an m-trifluoromethyl group, or n represents the numbers 0, 1 or 2, R3 and R4 together form a grouping of general formula (III) **(See formula)** where m'represents 1 or 2, R7, R8 and/or R9 signify hydrogen atoms, lower alkyl or lower alkoxy groups and/or halogen atoms or R7 and R8 signify hydrogen atoms and R9 signifies an m-trifluoromethyl group, as well as its pharmaceutically or therapeutically compatible acid addition salts, characterized in that an N-diphenylmethylpiperazine or -homopiperazine of general formula (IV) **(See formula)** Where R1, R2 and m have the definition above, it is reacted with a substituted α-halogen compound of general formula (V) **(See formula)** wherein R3 and R4 have the meanings above and X1 is a halogen atom, or an N-diphenylmethylpiperazine or -homopiperazine of general formula (VI) **(See formula)** wherein R1, R2, m, m'and n have the meaning defined above, are reacted with aromatic carboxylic acid derivatives of general formula (VII) **(See formula)** wherein R7, R8 and R9 have the above meaning and X2 signifies a halogen atom or may be a lower alkoxy group, or an N-substituted piperazine or homopiperazine of general formula (VIII) **(See formula)** Where m, n, R3 and R4 have the meaning defined above, it is reacted with a diphenylmethane derivative of general formula (IX) wherein R1 R2 and X1 have the meanings indicated above, or an N, N'-disubstituted piperazine or homopiperazine of general formula (X) **(See formula)** in which R1, R2, m, n and X1 have the meaning defined above, it is reacted with an amine of general formula (XI) **(See formula)** wherein R3 and R4 have the meaning above, and, if appropriate, the compounds thus obtained are converted with acids into the addition salts. (Machine-translation by Google Translate, not legally binding)
ES422737A 1973-01-29 1974-01-29 Procedure for the obtaining of heterociclic compounds based on piperazine or homopiperazine. (Machine-translation by Google Translate, not legally binding) Expired ES422737A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2304154A DE2304154A1 (en) 1973-01-29 1973-01-29 PROCESS FOR THE PRODUCTION OF SUBSTITUTED PIPERAZINE AND HOMOPIPERAZINE DERIVATIVES

Publications (1)

Publication Number Publication Date
ES422737A1 true ES422737A1 (en) 1976-08-01

Family

ID=5870201

Family Applications (1)

Application Number Title Priority Date Filing Date
ES422737A Expired ES422737A1 (en) 1973-01-29 1974-01-29 Procedure for the obtaining of heterociclic compounds based on piperazine or homopiperazine. (Machine-translation by Google Translate, not legally binding)

Country Status (6)

Country Link
JP (1) JPS505388A (en)
BE (1) BE810292A (en)
DE (1) DE2304154A1 (en)
ES (1) ES422737A1 (en)
FR (1) FR2215235A1 (en)
NL (1) NL7401216A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1190375B (en) * 1985-06-20 1988-02-16 Recordati Chem Pharm N-BENZHYDRYDIAZACYCLALCHYL-ALCANYLIDES WITH ANTIANAPHYLACTIC AND ANTIBRONCOSPASTIC ACTIVITY
PE20030705A1 (en) * 2001-10-17 2003-08-21 Schering Corp 17BETA-HYDROXIESTEROID DEHYDROGENASE TYPE 3 INHIBITORS FOR THE TREATMENT OF ANDROGEN-DEPENDENT DISEASES

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3244718A (en) * 1964-02-17 1966-04-05 Biel John Hans Piperazine derivatives
NL137318C (en) * 1964-06-09

Also Published As

Publication number Publication date
FR2215235A1 (en) 1974-08-23
DE2304154A1 (en) 1974-08-01
FR2215235B1 (en) 1977-11-04
BE810292A (en) 1974-05-16
NL7401216A (en) 1974-07-31
JPS505388A (en) 1975-01-21

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