ES422738A1 - N-acylated substituted piperazine or homopiperazine derivatives and processes for their preparation - Google Patents
N-acylated substituted piperazine or homopiperazine derivatives and processes for their preparationInfo
- Publication number
- ES422738A1 ES422738A1 ES422738A ES422738A ES422738A1 ES 422738 A1 ES422738 A1 ES 422738A1 ES 422738 A ES422738 A ES 422738A ES 422738 A ES422738 A ES 422738A ES 422738 A1 ES422738 A1 ES 422738A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- general formula
- acylated
- derivative
- piperazine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedure for obtaining heterocyclic compounds, based on N-acylated piperazine or homopipersizine of general formula (I) **(See formula)** wherein R1, R2 and/or R3 signify hydrogen atoms, lower or higher alkyl groups, halogen atoms and/or lower alkoxy groups, or R1 and R2 signify hydrogen atoms and R3 signifies an m-trifluoromethyl group, R4 is a valence bond, a methylene group, ethylidene or an ethylene group, n represents the number 1 or 2, R5 means a lower or higher alkyl group, an allyl or propargyl group, or a group of general formula (II) **(See formula)** where R6 and/or R7 signify hydrogen atoms, lower or higher alkyl or alkoxy groups and/or halogen atoms or R6 signifies a hydrogen atom and R7 can be an m-trifluoromethyl group and R8 signifies a hydrogen atom or a lower alkyl group, as well as its addition salts with quaternary ammonium acids and derivatives, pharmaceutically or therapeutically compatible, characterized in that a piperazine or homopiperazine derivative of general formula (III) **(See formula)** it is reacted with an acid derivative capable of N-acylation of the general formula (IV) **(See formula)** where R1, R2, R3, R4, R5 and n have the meaning defined above and R9 means a halogen atom or a lower alkoxy group, or a piperazine derivative or N-acylated homopiperazine of general formula (V) **(See formula)** N-acylated at the secondary nitrogen atom, with R1, R2, R3, R4 and n having the meaning defined above, either a piperazine derivative or N-acylated homopiperazine of general formula (V) is reacted with a halogenoacetyl derivative of general formula (VI) **(See formula)** where R6, R7 and R8 have the above defined meaning and R10 means a halogen atom. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2304155A DE2304155A1 (en) | 1973-01-29 | 1973-01-29 | N-ACYLATED SUBSTITUTED PIPERAZINE AND HOMOPIPERAZINE DERIVATIVES AND THE PROCESS FOR THEIR PRODUCTION |
Publications (1)
Publication Number | Publication Date |
---|---|
ES422738A1 true ES422738A1 (en) | 1976-08-01 |
Family
ID=5870202
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES422738A Expired ES422738A1 (en) | 1973-01-29 | 1974-01-29 | N-acylated substituted piperazine or homopiperazine derivatives and processes for their preparation |
Country Status (7)
Country | Link |
---|---|
JP (1) | JPS505389A (en) |
BE (1) | BE810293A (en) |
DE (1) | DE2304155A1 (en) |
ES (1) | ES422738A1 (en) |
FR (1) | FR2215236B1 (en) |
GB (1) | GB1434323A (en) |
NL (1) | NL7401215A (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4180574A (en) * | 1978-12-26 | 1979-12-25 | Abbott Laboratories | Certain ovicidal piperazines |
JPS5879986A (en) * | 1981-11-06 | 1983-05-13 | Otsuka Pharmaceut Co Ltd | Aniline derivative |
US4585774A (en) * | 1981-05-08 | 1986-04-29 | Otsuka Pharmaceutical Co., Ltd. | Aniline derivatives and cardiotonic composition |
US6207665B1 (en) | 1997-06-12 | 2001-03-27 | Schering Aktiengesellschaft | Piperazine derivatives and their use as anti-inflammatory agents |
US6677343B2 (en) * | 2000-02-22 | 2004-01-13 | Cv Therapeutics, Inc. | Substituted piperazine compounds |
US7208497B2 (en) | 2001-07-02 | 2007-04-24 | Novo Nordisk A/S | Substituted piperazines and diazepanes |
DE60234453D1 (en) * | 2001-07-02 | 2009-12-31 | High Point Pharmaceuticals Llc | SUBSTITUTED PIPERAZINE AND DIAZEPANDERIVATES FOR USE AS HISTAMINE H3 RECEPTOR MODULATORS |
EP1755605A2 (en) * | 2004-04-15 | 2007-02-28 | Samaritan Pharmaceuticals, Inc. | Use of (4-alkylpiperazinyl)(phenyl) methanones in the treatment of alzheimer's disease |
JP2008007443A (en) * | 2006-06-28 | 2008-01-17 | Shiseido Co Ltd | Cinnamic acid derivative, application of the same as ultraviolet ray absorber and ultraviolet ray absorbing composition formulated with the same, skin care preparation |
WO2009031202A1 (en) * | 2007-09-04 | 2009-03-12 | Shiseido Company Ltd. | Cinnamic acid derivatives and use thereof as ultraviolet absorber |
AU2010291834A1 (en) * | 2009-09-04 | 2012-03-15 | Zalicus Pharmaceuticals Ltd. | Substituted heterocyclic derivatives for the treatment of pain and epilepsy |
EP2961403A4 (en) | 2013-03-01 | 2016-11-30 | Zalicus Pharmaceuticals Ltd | Heterocyclic inhibitors of the sodium channel |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE774447A (en) * | 1970-11-11 | 1972-02-14 | Biasedra Lab | NEW DERIVATIVES OF SALICYLAMIDE AND THEIR APPLICATION IN THERAPEUTICS |
-
1973
- 1973-01-29 DE DE2304155A patent/DE2304155A1/en active Pending
-
1974
- 1974-01-28 GB GB378474A patent/GB1434323A/en not_active Expired
- 1974-01-29 ES ES422738A patent/ES422738A1/en not_active Expired
- 1974-01-29 JP JP49012644A patent/JPS505389A/ja active Pending
- 1974-01-29 NL NL7401215A patent/NL7401215A/xx unknown
- 1974-01-29 BE BE140287A patent/BE810293A/en unknown
- 1974-01-29 FR FR7402849A patent/FR2215236B1/fr not_active Expired
Also Published As
Publication number | Publication date |
---|---|
NL7401215A (en) | 1974-07-31 |
JPS505389A (en) | 1975-01-21 |
DE2304155A1 (en) | 1974-08-01 |
FR2215236B1 (en) | 1977-11-04 |
BE810293A (en) | 1974-05-16 |
FR2215236A1 (en) | 1974-08-23 |
GB1434323A (en) | 1976-05-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GB1047935A (en) | Substituted piperazines and preparation thereof | |
ES467288A1 (en) | N-(substituted-aminoalkyl)-2-oxo-1-pyrrolidineacetamides | |
ES422738A1 (en) | N-acylated substituted piperazine or homopiperazine derivatives and processes for their preparation | |
GB1120463A (en) | Derivatives of 1,3-diazafluoranthene-1-oxide | |
ES413639A1 (en) | Dopamine derivatives | |
ES387016A1 (en) | Isoquinoline derivatives | |
ES405942A1 (en) | 2-phenylimino-imidazolidines,their 2-aniline-2-imidazoline tautomers and salts thereof | |
ES331339A1 (en) | Procedure for the preparation of substitute alkylpenidines. (Machine-translation by Google Translate, not legally binding) | |
ES391633A1 (en) | 2,2,-diaryl-4-4-aryl-4-hydroxy-piperidino butyramides | |
ES428400A1 (en) | Pheno aldehydes | |
ES423058A1 (en) | 3-(isopropyl amino alkoxy)-2-phenyl-isoindolin-1-ones | |
ES390163A1 (en) | Procedure for the preparation of amino-derivatives of pirazolo (3,4-b) pyridine-5-carboxylic acids. (Machine-translation by Google Translate, not legally binding) | |
ES417700A1 (en) | Basically substituted benzene-1,3-disulfonamides and process for their manufacture | |
ES393934A2 (en) | Derivatives of theophylline | |
ES419019A1 (en) | Indolo-2,3-c quinolinone derivatives | |
ES433131A1 (en) | Derivatives of 1-phenoxy-3-aminopropan-2-ol and processes for their preparation | |
ES422737A1 (en) | Procedure for the obtaining of heterociclic compounds based on piperazine or homopiperazine. (Machine-translation by Google Translate, not legally binding) | |
ES301524A1 (en) | Procedure for the preparation of antivirus compositions in a unit dosage form (Machine-translation by Google Translate, not legally binding) | |
ES435351A1 (en) | 1-(3-phenylpropyl)-4-furoylpiperazine derivatives | |
ES442710A1 (en) | A procedure for preparing new piperazine derivatives. (Machine-translation by Google Translate, not legally binding) | |
ES400414A1 (en) | Procedure for the preparation of N-substituted piperidine derivatives and their use as stabilizers. (Machine-translation by Google Translate, not legally binding) | |
ES401342A1 (en) | Pyridine derivatives | |
ES406417A1 (en) | Basically substituted alkyltheophyline derivatives | |
ES433593A1 (en) | Antibacterial cyanoquinoxaline 1,4-dioxides | |
ES416230A1 (en) | Procedure for the preparation of a compound benzamide hete rociclico. (Machine-translation by Google Translate, not legally binding) |