ES390163A1 - Procedure for the preparation of amino-derivatives of pirazolo (3,4-b) pyridine-5-carboxylic acids. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of amino-derivatives of pirazolo (3,4-b) pyridine-5-carboxylic acids. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES390163A1
ES390163A1 ES390163A ES390163A ES390163A1 ES 390163 A1 ES390163 A1 ES 390163A1 ES 390163 A ES390163 A ES 390163A ES 390163 A ES390163 A ES 390163A ES 390163 A1 ES390163 A1 ES 390163A1
Authority
ES
Spain
Prior art keywords
alcohol
hydrogen
translation
phenyl
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES390163A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of ES390163A1 publication Critical patent/ES390163A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

A procedure for preparing a compound of the formula: **(See formula)** where R is hydrogen or lower alcohol, R1 is lower alcohol, phenyl or lower phenyl-alcohol, R2 is hydrogen or lower alcohol, R3 and R4 are each hydrogen, lower alcohol, phenyl-R5, R6, lower phenyl-alcohol, dialkohilamino lower lower alcoholylene or R3 and R4 together with the nitrogen to which they are attached form one of the heterocyclic pyrrolidino-R7, R8, piperidino-R7, R8, pyrazolyl-R7, R8, pyrimidinyl-R7, R8, pyridazinyl-R7, R8, dihydropyridazinyl-R7, R8 or piperazinyl-R7, R8, R5 and R6 are each hydrogen, lower alcohol, trifluoromethyl or carboxy, and R7 and R8 are each hydrogen, lower alcohol or lower hydroxyalkyl, and their acid addition salts, which comprises reacting a compound of one of the following formulas: **(See formula)** where R, R1 and R2 are as previously described and X is chlorine or bromine, with an amine of the formula **(See formula)** where R3 and R4 are as previously defined. (Machine-translation by Google Translate, not legally binding)
ES390163A 1970-05-28 1971-04-14 Procedure for the preparation of amino-derivatives of pirazolo (3,4-b) pyridine-5-carboxylic acids. (Machine-translation by Google Translate, not legally binding) Expired ES390163A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4156870A 1970-05-28 1970-05-28

Publications (1)

Publication Number Publication Date
ES390163A1 true ES390163A1 (en) 1973-07-01

Family

ID=21917210

Family Applications (1)

Application Number Title Priority Date Filing Date
ES390163A Expired ES390163A1 (en) 1970-05-28 1971-04-14 Procedure for the preparation of amino-derivatives of pirazolo (3,4-b) pyridine-5-carboxylic acids. (Machine-translation by Google Translate, not legally binding)

Country Status (13)

Country Link
JP (1) JPS554105B1 (en)
BE (1) BE767842A (en)
CA (1) CA920592A (en)
CH (1) CH527208A (en)
DE (1) DE2123318C2 (en)
ES (1) ES390163A1 (en)
FR (1) FR2100698A1 (en)
HU (1) HU163173B (en)
IE (1) IE35118B1 (en)
NL (1) NL172657C (en)
SE (1) SE367202B (en)
YU (1) YU37344B (en)
ZA (1) ZA711710B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3804843A (en) * 1971-12-23 1974-04-16 Squibb & Sons Inc Amino derivatives of pyrazolopyridine carbonitriles
BE787794A (en) * 1972-06-13 1973-02-21 Fratmann Ag PROCESS FOR THE PREPARATION OF N- (1-ETHYL-ALPHA-PYRROLIDYLMETHYL) - 2-METHOXY-5-SULFAMIDOBENZAMIDE
US3835144A (en) * 1972-06-16 1974-09-10 Squibb & Sons Inc Amino derivatives of (4,3-c pyrazolopyridine cabroxylic acids and esters
US3840546A (en) * 1972-11-15 1974-10-08 Squibb & Sons Inc Amino derivatives of pyrazolopyridine carboxamides
US3833598A (en) * 1972-12-29 1974-09-03 Squibb & Sons Inc Amino derivatives of pyrazolopyridine-6-carboxylic acids and esters
CA2706571C (en) * 2007-12-19 2012-11-27 Genentech, Inc. 5-anilinoimidazopyridines and methods of use
US8841462B2 (en) * 2008-07-01 2014-09-23 Robert A. Heald Bicyclic heterocycles as MEK kinase inhibitors
JP5615274B2 (en) 2008-07-01 2014-10-29 ジェネンテック， インコーポレイテッド Isoindolone derivatives as MEK kinase inhibitors and methods of use thereof

Also Published As

Publication number Publication date
BE767842A (en) 1971-11-29
CA920592A (en) 1973-02-06
IE35118L (en) 1971-11-28
IE35118B1 (en) 1975-11-12
SE367202B (en) 1974-05-20
YU106671A (en) 1983-04-27
DE2123318A1 (en) 1971-12-09
NL172657B (en) 1983-05-02
FR2100698A1 (en) 1972-03-24
NL172657C (en) 1983-10-03
FR2100698B1 (en) 1974-08-23
HU163173B (en) 1973-06-28
CH527208A (en) 1972-08-31
YU37344B (en) 1984-08-31
ZA711710B (en) 1971-12-29
DE2123318C2 (en) 1984-05-03
JPS554105B1 (en) 1980-01-29
NL7106688A (en) 1971-11-30

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