ES325271A1 - Procedure for the preparation of new substitute phenylacetic acids (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of new substitute phenylacetic acids (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES325271A1 ES325271A1 ES0325271A ES325271A ES325271A1 ES 325271 A1 ES325271 A1 ES 325271A1 ES 0325271 A ES0325271 A ES 0325271A ES 325271 A ES325271 A ES 325271A ES 325271 A1 ES325271 A1 ES 325271A1
- Authority
- ES
- Spain
- Prior art keywords
- radical
- alkyl
- translation
- preparation
- legally binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Process for the preparation of new substituted phenylacetic acids, of the general formula I ** (See formula) ** in which R1 means an alkyl or lower alkoxy radical, a halogen atom up to the atomic number 35 or the trifluoromethyl group, R2 and R3 each denote hydrogen, an alkyl or lower alkoxy radical, or a halogen atom up to the atomic number 35, R4 means hydrogen, an alkyl or lower alkoxy radical, a halogen atom up to the atomic number 35 or the trifluoromethyl group, R5 and R6 each denote hydrogen, a lower alkyl radical or a benzyl radical, and its salts with inorganic and organic bases, characterized in that a compound of the general formula II ** (See formula) ** in which R1-R6 have the significance stated above, A means hydrogen or an acyl radical, especially a lower alkanoyl radical, and X stands for a lower alkoxycarbonyl or aralkoxycarbonyl group, especially the benzyloxycarbonyl radical, or the nitrile group, it is reacted hot in an alkaline medium and, if desired, the acid is released from a salt thus obtained. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH496165A CH460804A (en) | 1965-04-08 | 1965-04-08 | Process for the production of new substituted phenylacetic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES325271A1 true ES325271A1 (en) | 1967-04-01 |
Family
ID=4285534
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0325271A Expired ES325271A1 (en) | 1965-04-08 | 1966-04-06 | Procedure for the preparation of new substitute phenylacetic acids (Machine-translation by Google Translate, not legally binding) |
| ES0325270A Expired ES325270A1 (en) | 1965-04-08 | 1966-04-06 | Procedure for the preparation of new substitute phenylacetic acids. (Machine-translation by Google Translate, not legally binding) |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0325270A Expired ES325270A1 (en) | 1965-04-08 | 1966-04-06 | Procedure for the preparation of new substitute phenylacetic acids. (Machine-translation by Google Translate, not legally binding) |
Country Status (16)
| Country | Link |
|---|---|
| AT (4) | AT262983B (en) |
| BE (1) | BE679315A (en) |
| CH (1) | CH460804A (en) |
| CY (1) | CY637A (en) |
| DE (1) | DE1543639B2 (en) |
| DK (1) | DK117639B (en) |
| DO (2) | DOP1977002615A (en) |
| ES (2) | ES325271A1 (en) |
| FI (1) | FI44619C (en) |
| FR (2) | FR1487352A (en) |
| GB (1) | GB1139332A (en) |
| IL (1) | IL25545A (en) |
| MY (1) | MY7200118A (en) |
| NL (2) | NL6604752A (en) |
| NO (1) | NO120793B (en) |
| SE (1) | SE322527B (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3513199A (en) * | 1967-05-05 | 1970-05-19 | Smithkline Corp | Substituted anilino benzyl alcohols |
| CH506480A (en) * | 1969-02-20 | 1971-04-30 | Ciba Geigy Ag | Process for the production of new, substituted o-anilino-phenethyl alcohols |
| JPS549240A (en) * | 1977-06-23 | 1979-01-24 | Asahi Chem Ind Co Ltd | New derivative of phenylglycolic acid, its preparation and analgesic and antiinflammatory agent contining it as effective component |
| JPS58194814A (en) * | 1982-05-11 | 1983-11-12 | Nippon Shinyaku Co Ltd | Drug having immunoregulating activity |
| US5237070A (en) * | 1985-07-22 | 1993-08-17 | Riker Laboratories, Inc. | Substituted DI-t-butylphenols |
| ZA865090B (en) * | 1985-07-22 | 1988-02-24 | Riker Laboratories Inc | Substituted di-t-butylphenols |
| DE3623193A1 (en) * | 1986-07-10 | 1988-01-14 | Gruenenthal Gmbh | NEW COMPOUNDS, THIS MEDICINAL PRODUCT AND METHOD FOR THE PRODUCTION THEREOF |
| ES2011588A6 (en) * | 1989-05-29 | 1990-01-16 | Vinas Lab | Phenylacetic acid derivative. |
| EP0405602A1 (en) * | 1989-06-30 | 1991-01-02 | Laboratorios Vinas S.A. | New Zinc derivatives of anti-inflammatory drugs having improved therapeutic activity |
| US6355680B1 (en) * | 1996-02-20 | 2002-03-12 | Exocell, Inc. | Albumin-binding compounds that prevent nonenzymatic glycation and that may be used for treatment of glycation-related pathologies |
| AR061623A1 (en) | 2006-06-26 | 2008-09-10 | Novartis Ag | PHENYLACETIC ACID DERIVATIVES |
| CN114539086B (en) | 2022-02-25 | 2023-10-03 | 复旦大学 | Synthesis method of diclofenac sodium |
| CN114516813B (en) | 2022-02-25 | 2024-05-28 | 复旦大学 | Continuous flow preparation method of diclofenac sodium |
-
0
- NL NL133740D patent/NL133740C/xx active
-
1965
- 1965-04-08 FR FR57111A patent/FR1487352A/en not_active Expired
- 1965-04-08 CH CH496165A patent/CH460804A/en unknown
-
1966
- 1966-04-06 NO NO162524A patent/NO120793B/no unknown
- 1966-04-06 FI FI660898A patent/FI44619C/en active
- 1966-04-06 DK DK180566AA patent/DK117639B/en unknown
- 1966-04-06 ES ES0325271A patent/ES325271A1/en not_active Expired
- 1966-04-06 ES ES0325270A patent/ES325270A1/en not_active Expired
- 1966-04-07 NL NL6604752A patent/NL6604752A/xx unknown
- 1966-04-07 AT AT619667A patent/AT262983B/en active
- 1966-04-07 AT AT619567A patent/AT262982B/en active
- 1966-04-07 SE SE4833/66A patent/SE322527B/xx unknown
- 1966-04-07 AT AT334966A patent/AT263755B/en active
- 1966-04-07 GB GB15497/66A patent/GB1139332A/en not_active Expired
- 1966-04-07 DE DE1966G0046553 patent/DE1543639B2/en active Granted
- 1966-04-07 AT AT619767A patent/AT266096B/en active
- 1966-04-07 IL IL25545A patent/IL25545A/en unknown
- 1966-04-08 BE BE679315D patent/BE679315A/xx not_active IP Right Cessation
- 1966-07-06 FR FR68443A patent/FR5524M/fr not_active Expired
-
1972
- 1972-04-19 CY CY63772A patent/CY637A/en unknown
- 1972-12-31 MY MY1972118A patent/MY7200118A/en unknown
-
1977
- 1977-11-21 DO DO1977002615A patent/DOP1977002615A/en unknown
- 1977-12-09 DO DO1977002614A patent/DOP1977002614A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BE679315A (en) | 1966-10-10 |
| CY637A (en) | 1972-04-19 |
| ES325270A1 (en) | 1967-04-01 |
| AT266096B (en) | 1968-11-11 |
| NL6604752A (en) | 1966-10-10 |
| AT262983B (en) | 1968-07-10 |
| NO120793B (en) | 1970-12-07 |
| MY7200118A (en) | 1972-12-31 |
| SE322527B (en) | 1970-04-13 |
| CH460804A (en) | 1968-08-15 |
| FI44619C (en) | 1971-12-10 |
| GB1139332A (en) | 1969-01-08 |
| DOP1977002615A (en) | 1983-05-27 |
| DOP1977002614A (en) | 1983-05-27 |
| FR1487352A (en) | 1967-07-07 |
| DE1793592A1 (en) | 1972-04-20 |
| NL133740C (en) | |
| DE1543639B2 (en) | 1977-02-24 |
| DE1543639A1 (en) | 1970-02-05 |
| FR5524M (en) | 1967-11-06 |
| AT262982B (en) | 1968-07-10 |
| IL25545A (en) | 1970-07-19 |
| DK117639B (en) | 1970-05-19 |
| FI44619B (en) | 1971-08-31 |
| AT263755B (en) | 1968-08-12 |
| DE1793592B2 (en) | 1977-06-16 |
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