ES386586A1 - N-phenyl-n-disubstituted aminoalkyl-2-amino indanes - Google Patents

N-phenyl-n-disubstituted aminoalkyl-2-amino indanes

Info

Publication number
ES386586A1
ES386586A1 ES386586A ES386586A ES386586A1 ES 386586 A1 ES386586 A1 ES 386586A1 ES 386586 A ES386586 A ES 386586A ES 386586 A ES386586 A ES 386586A ES 386586 A1 ES386586 A1 ES 386586A1
Authority
ES
Spain
Prior art keywords
formula
phenyl
acid addition
amino
see formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES386586A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MANUF PROD PHARMA
Original Assignee
MANUF PROD PHARMA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MANUF PROD PHARMA filed Critical MANUF PROD PHARMA
Publication of ES386586A1 publication Critical patent/ES386586A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
    • C07C211/53—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring having the nitrogen atom of at least one of the amino groups further bound to a hydrocarbon radical substituted by amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A method of preparing new 2-amino-indane derivatives of the general formula ** (See formula) ** where n is equal to 2 or 3, R1 and R2 each represent a lower alcohol group or together with the adjacent nitrogen atom form a nitrogen heterocyclic ring and R2 is optional and, when present, represents one or more substituents than they can be attached to the N-phenyl ring in the ortho, meta and/or para positions, as well as the acid addition salts of said derivatives of formula I, which consists in reacting an N-phenyl-2-aminoindane of the formula ** (See formula) ** with sodium amide (NaNH2) and with a chlorinated amine of the formula ** (See formula) ** wherein n, R1, R2 and R3 have the above meanings, the compound obtained being optionally converted, in a manner known per se, into an acid addition salt. (Machine-translation by Google Translate, not legally binding)
ES386586A 1969-12-19 1970-12-18 N-phenyl-n-disubstituted aminoalkyl-2-amino indanes Expired ES386586A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB6207369 1969-12-19

Publications (1)

Publication Number Publication Date
ES386586A1 true ES386586A1 (en) 1973-11-16

Family

ID=10487848

Family Applications (1)

Application Number Title Priority Date Filing Date
ES386586A Expired ES386586A1 (en) 1969-12-19 1970-12-18 N-phenyl-n-disubstituted aminoalkyl-2-amino indanes

Country Status (9)

Country Link
AT (1) AT298478B (en)
BE (1) BE760018A (en)
CH (1) CH521941A (en)
ES (1) ES386586A1 (en)
FR (1) FR2081383B1 (en)
GB (1) GB1321424A (en)
LU (1) LU62232A1 (en)
NL (1) NL150099B (en)
SE (1) SE372258B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR206999A1 (en) * 1972-11-06 1976-09-09 Christiaens Sa A PROCEDURE FOR THE PREPARATION OF NEW N-PHENYL-2-AMINOINDANE DERIVATIVES
GB1468347A (en) * 1973-03-02 1977-03-23 Christiaens Sa A Aminoindanes
US4975461A (en) * 1986-06-19 1990-12-04 E. R. Squibb & Sons, Inc. P-aminophenols, derivatives thereof and method of use
MXPA01012632A (en) * 1999-06-10 2004-03-19 Bridge Pharma Inc Dermal anesthetic agents.
EP1658847A3 (en) * 1999-06-10 2006-07-26 Bridge Pharma, Inc. Indane derivatives as dermal anesthetic agents
WO2006036936A2 (en) 2004-09-27 2006-04-06 Bridge Pharma, Inc. The s-isomer of 2-{2-[n-(2-indanyl)-n-phenylamino]ethyl}piperidine and other dermal anesthetic agents
US7592458B2 (en) 2006-07-21 2009-09-22 Wright George E Dermal anesthetic compounds and pharmaceutical compositions for inducing local anesthesia and mitigating neuropathic pain
UA112769C2 (en) 2011-02-18 2016-10-25 Ендо Фармасьютікалз Інк. AMINO-INDANE COMPOUNDS AND THEIR APPLICATIONS IN THE TREATMENT OF PAIN
US9044482B2 (en) 2012-08-15 2015-06-02 Asana Biosciences, Llc Use of aminoindane compounds in treating overactive bladder and interstitial cystitis

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2670371A (en) * 1951-08-01 1954-02-23 Searle & Co Basic alkyl substitution products of n-indanyl and n-tetrahydronaphthyl-monocarbocyclylamides and their salts

Also Published As

Publication number Publication date
FR2081383A1 (en) 1971-12-03
NL150099B (en) 1976-07-15
CH521941A (en) 1972-04-30
LU62232A1 (en) 1971-05-11
BE760018A (en) 1971-06-08
FR2081383B1 (en) 1975-04-18
GB1321424A (en) 1973-06-27
NL7018508A (en) 1971-06-22
SE372258B (en) 1974-12-16
DE2060721B2 (en) 1976-02-26
DE2060721A1 (en) 1971-06-24
AT298478B (en) 1972-05-10

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