ES391026A1 - Benzonaphthyridine derivatives - Google Patents

Benzonaphthyridine derivatives

Info

Publication number
ES391026A1
ES391026A1 ES391026A ES391026A ES391026A1 ES 391026 A1 ES391026 A1 ES 391026A1 ES 391026 A ES391026 A ES 391026A ES 391026 A ES391026 A ES 391026A ES 391026 A1 ES391026 A1 ES 391026A1
Authority
ES
Spain
Prior art keywords
carbon atoms
formula
hydrogen
chlorine
trifluoromethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES391026A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH708670A external-priority patent/CH527196A/en
Priority claimed from CH708970A external-priority patent/CH527822A/en
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES391026A1 publication Critical patent/ES391026A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedure for obtaining benzonaphthyridine of formula I ** (See formula) ** wherein R1 is hydrogen, C1-3alkyl, C1-3alkoxy or C1-3alkylthio, fluorine, chlorine, bromine, nitro, trifluoromethyl, amino or 2-4 amido carbon atoms, R2 is hydrogen, chlorine, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 3 carbon atoms, and R3 and R4 signify each other hydrogen or methoxy, or R3 and R4 together are methylenedioxy, characterized by that a 3,4-cis-substituted compound of formula II is cyclized, ** (See formula) ** where R2, R3, and R4 have the meanings indicated above, and RI1 is hydrogen, alkyl of 1 to 3 carbon atoms, alkoxy of 1 to 3 carbon atoms or alkylthio of 1 to 3 carbon atoms, fluorine, chlorine, bromine, nitro or trifluoromethyl, with a dehydrating condensing agent, acid, to obtain a compound of formula Ia, ** (See formula) ** where RI1, R2, R3 and R4 have the meanings indicated above. (Machine-translation by Google Translate, not legally binding)
ES391026A 1970-05-13 1971-05-11 Benzonaphthyridine derivatives Expired ES391026A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH708670A CH527196A (en) 1970-05-13 1970-05-13 Process for the preparation of new benzonaphthyridine derivatives
CH708970A CH527822A (en) 1970-05-13 1970-05-13 Cis-1,2,,3,4,4a-10b-hexahydro-2-methyl-6-phenyl benzo - (c) (1,6) naphthyridine derivs

Publications (1)

Publication Number Publication Date
ES391026A1 true ES391026A1 (en) 1974-04-01

Family

ID=25700728

Family Applications (1)

Application Number Title Priority Date Filing Date
ES391026A Expired ES391026A1 (en) 1970-05-13 1971-05-11 Benzonaphthyridine derivatives

Country Status (14)

Country Link
JP (1) JPS5432799B1 (en)
AT (1) AT326674B (en)
CA (1) CA970377A (en)
CS (2) CS162753B2 (en)
DE (1) DE2123328A1 (en)
DK (1) DK134488B (en)
ES (1) ES391026A1 (en)
FI (1) FI52089C (en)
FR (1) FR2100649B1 (en)
GB (1) GB1361441A (en)
NL (1) NL7106502A (en)
PL (1) PL76913B1 (en)
SE (1) SE387640B (en)
SU (1) SU423296A3 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3899494A (en) * 1970-05-13 1975-08-12 Sandoz Ltd Substituted 6-phenyl benzo-naphthyridines
NL7314396A (en) * 1972-10-26 1974-05-01
BE880455A (en) * 1979-01-22 1980-06-06 Sandoz Sa PHARMACEUTICAL COMPOSITIONS BASED ON A BENZO (C) (1,6) NAPHTYRIDINE
JP2002502403A (en) 1997-06-03 2002-01-22 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング Benzonaphthyridine
SK287231B6 (en) 1999-08-21 2010-04-07 Nycomed Gmbh Medicament comprising a PDE inhibitor and a beta2 adrenoreceptor agonist
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
BRPI0409229A (en) 2003-04-01 2006-03-28 Applied Research Systems phosphodiesterase inhibitors in infertility
JP2007537233A (en) * 2004-05-12 2007-12-20 ファイザー・プロダクツ・インク Piperidine derivatives as NK1 and NK3 antagonists
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CA2688161C (en) 2007-06-04 2020-10-20 Kunwar Shailubhai Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2522968T3 (en) 2008-06-04 2014-11-19 Synergy Pharmaceuticals Inc. Guanylate cyclase agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2624828T3 (en) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Guanylate cyclase agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer and others
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN108676076A (en) 2011-03-01 2018-10-19 辛纳吉制药公司 The method for preparing guanosine cyclic mono-phosphate agonist
WO2014131024A2 (en) 2013-02-25 2014-08-28 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
JP6606491B2 (en) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド Ultra high purity agonist of guanylate cyclase C, method for producing and using the same
MX2016001714A (en) 2013-08-09 2016-10-03 Ardelyx Inc Compounds and methods for inhibiting phosphate transport.
WO2020237096A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Combination for lowering serum phosphate in a patient

Also Published As

Publication number Publication date
AT326674B (en) 1975-12-29
ATA412471A (en) 1975-03-15
SE387640B (en) 1976-09-13
CS167202B2 (en) 1976-04-29
FI52089B (en) 1977-02-28
FR2100649A1 (en) 1972-03-24
FI52089C (en) 1977-06-10
NL7106502A (en) 1971-11-16
CS162753B2 (en) 1975-07-15
CA970377A (en) 1975-07-01
JPS5432799B1 (en) 1979-10-16
DE2123328A1 (en) 1971-12-02
DK134488B (en) 1976-11-15
DK134488C (en) 1977-05-16
PL76913B1 (en) 1975-02-28
GB1361441A (en) 1974-07-24
SU423296A3 (en) 1974-04-05
FR2100649B1 (en) 1974-08-30

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