IE35118B1 - Amino derivatives of pyrazolo-pyridine carboxylic acids and esters and salts thereof - Google Patents
Amino derivatives of pyrazolo-pyridine carboxylic acids and esters and salts thereofInfo
- Publication number
- IE35118B1 IE35118B1 IE379/71A IE37971A IE35118B1 IE 35118 B1 IE35118 B1 IE 35118B1 IE 379/71 A IE379/71 A IE 379/71A IE 37971 A IE37971 A IE 37971A IE 35118 B1 IE35118 B1 IE 35118B1
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl
- salts
- pyrazolo
- esters
- carboxylic acids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The new cpds are of formula: in which R is H or alkyl, R1 is alkyl, phenyl or phenyl alkylene, R2 is H or alkyl, R3 and R4 are H, alkyl, phenylalkylene, dialkylamino-alkylene or R5, R6-phenyl where R5 and R6 are H, alkyl, CF3 or COOH, or NR3R4 represents R7, R8-pyrrolidino, R7, R8 pyridazinyl R7, R8-piperidino, R7, R8-pyrazolyl, R7, R8-pyrimidyl R7, R8 dihydropyridazinyl or R7, R8-piperazinyl, where R7 and R8 are H, alkyl or hydeozyalkyl, (all alkyl gps being lower alkyl) together with their acid addn salts. They are prepared by reaction of the corres. 4-alkoxy, or 4-halo-cpds with HNR3R4. They have CNS depressant antiinflammatory and analgesic activity, and may be used in the treatment of asthma.
[FR2100698A1]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4156870A | 1970-05-28 | 1970-05-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE35118L IE35118L (en) | 1971-11-28 |
| IE35118B1 true IE35118B1 (en) | 1975-11-12 |
Family
ID=21917210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE379/71A IE35118B1 (en) | 1970-05-28 | 1971-03-23 | Amino derivatives of pyrazolo-pyridine carboxylic acids and esters and salts thereof |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS554105B1 (en) |
| BE (1) | BE767842A (en) |
| CA (1) | CA920592A (en) |
| CH (1) | CH527208A (en) |
| DE (1) | DE2123318C2 (en) |
| ES (1) | ES390163A1 (en) |
| FR (1) | FR2100698A1 (en) |
| HU (1) | HU163173B (en) |
| IE (1) | IE35118B1 (en) |
| NL (1) | NL172657C (en) |
| SE (1) | SE367202B (en) |
| YU (1) | YU37344B (en) |
| ZA (1) | ZA711710B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9206174B2 (en) | 2007-12-19 | 2015-12-08 | Genentech, Inc. | 5-anilinoimidazopyridines and methods of use |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3804843A (en) * | 1971-12-23 | 1974-04-16 | Squibb & Sons Inc | Amino derivatives of pyrazolopyridine carbonitriles |
| BE787794A (en) * | 1972-06-13 | 1973-02-21 | Fratmann Ag | PROCESS FOR THE PREPARATION OF N- (1-ETHYL-ALPHA-PYRROLIDYLMETHYL) - 2-METHOXY-5-SULFAMIDOBENZAMIDE |
| US3835144A (en) * | 1972-06-16 | 1974-09-10 | Squibb & Sons Inc | Amino derivatives of (4,3-c pyrazolopyridine cabroxylic acids and esters |
| US3840546A (en) * | 1972-11-15 | 1974-10-08 | Squibb & Sons Inc | Amino derivatives of pyrazolopyridine carboxamides |
| US3833598A (en) * | 1972-12-29 | 1974-09-03 | Squibb & Sons Inc | Amino derivatives of pyrazolopyridine-6-carboxylic acids and esters |
| AU2009266956B2 (en) | 2008-07-01 | 2014-03-20 | Genentech, Inc. | Bicyclic heterocycles as MEK kinase inhibitors |
| CN102137843A (en) | 2008-07-01 | 2011-07-27 | 健泰科生物技术公司 | Isoindolone derivatives as MEK kinase inhibitors and methods of use |
-
1971
- 1971-03-16 CA CA107869A patent/CA920592A/en not_active Expired
- 1971-03-16 ZA ZA711710A patent/ZA711710B/en unknown
- 1971-03-23 IE IE379/71A patent/IE35118B1/en unknown
- 1971-04-14 ES ES390163A patent/ES390163A1/en not_active Expired
- 1971-04-21 HU HUSU614A patent/HU163173B/hu unknown
- 1971-04-28 YU YU1066/71A patent/YU37344B/en unknown
- 1971-05-03 CH CH652971A patent/CH527208A/en not_active IP Right Cessation
- 1971-05-11 JP JP3147571A patent/JPS554105B1/ja active Pending
- 1971-05-11 DE DE2123318A patent/DE2123318C2/en not_active Expired
- 1971-05-14 NL NLAANVRAGE7106688,A patent/NL172657C/en not_active IP Right Cessation
- 1971-05-27 FR FR7119340A patent/FR2100698A1/en active Granted
- 1971-05-27 SE SE06895/71A patent/SE367202B/xx unknown
- 1971-05-28 BE BE767842A patent/BE767842A/en not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9206174B2 (en) | 2007-12-19 | 2015-12-08 | Genentech, Inc. | 5-anilinoimidazopyridines and methods of use |
Also Published As
| Publication number | Publication date |
|---|---|
| NL172657C (en) | 1983-10-03 |
| JPS554105B1 (en) | 1980-01-29 |
| SE367202B (en) | 1974-05-20 |
| NL7106688A (en) | 1971-11-30 |
| ES390163A1 (en) | 1973-07-01 |
| DE2123318A1 (en) | 1971-12-09 |
| DE2123318C2 (en) | 1984-05-03 |
| CA920592A (en) | 1973-02-06 |
| CH527208A (en) | 1972-08-31 |
| FR2100698B1 (en) | 1974-08-23 |
| YU106671A (en) | 1983-04-27 |
| YU37344B (en) | 1984-08-31 |
| NL172657B (en) | 1983-05-02 |
| IE35118L (en) | 1971-11-28 |
| HU163173B (en) | 1973-06-28 |
| BE767842A (en) | 1971-11-29 |
| ZA711710B (en) | 1971-12-29 |
| FR2100698A1 (en) | 1972-03-24 |
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