FR1604911A - Amides and basic esters of 2-chloronicotinic acid - - with antiinflammatory and antispasmodic activity - Google Patents

Amides and basic esters of 2-chloronicotinic acid - - with antiinflammatory and antispasmodic activity

Info

Publication number
FR1604911A
FR1604911A FR1604911DA FR1604911A FR 1604911 A FR1604911 A FR 1604911A FR 1604911D A FR1604911D A FR 1604911DA FR 1604911 A FR1604911 A FR 1604911A
Authority
FR
France
Prior art keywords
antiinflammatory
alkyl
amides
cpds
chloronicotinic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Other languages
French (fr)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Application granted granted Critical
Publication of FR1604911A publication Critical patent/FR1604911A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Cpds. of formula (I): and their acid-addn. salts, (where n is 0 or 1; R is 1-4C alkylene; R1 and R2 separately are H; alkyl, phenyl, opt. substd. by >=1 OH, alkyl, CF3, CO2H; dialkylamino- alkyl; provided that both R1 and R2 are not H; -Nr1R2 may be a heterocyclic ring (alkyl gps. in substnts. have 1-4C). The cpds. are antiinflammatory and antispasmodic agents are inters. for other drugs. The cpds. are prepd. by reaction of 2-chloronicotinoyl halides, pref. the chloride with amines of formula: pref. in an anhydrous solvent, e.g., at 50-100 degrees C.
FR1604911D 1965-04-20 1966-04-07 Amides and basic esters of 2-chloronicotinic acid - - with antiinflammatory and antispasmodic activity Expired FR1604911A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1661465 1965-04-20

Publications (1)

Publication Number Publication Date
FR1604911A true FR1604911A (en) 1971-05-15

Family

ID=10080500

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1604911D Expired FR1604911A (en) 1965-04-20 1966-04-07 Amides and basic esters of 2-chloronicotinic acid - - with antiinflammatory and antispasmodic activity

Country Status (2)

Country Link
DE (1) DE1595900A1 (en)
FR (1) FR1604911A (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0323881B1 (en) * 1988-01-04 1993-03-31 E.I. Du Pont De Nemours And Company Cyano-dienes, halopyridines, intermediates and a process for their preparation
AU617756B2 (en) * 1988-01-04 1991-12-05 E.I. Du Pont De Nemours And Company Cyano-dienes, halopyridines, intermediates and a process for their preparation
US4973597A (en) * 1989-06-30 1990-11-27 Eli Lilly And Company Anticonvulsant agents

Also Published As

Publication number Publication date
DE1595900A1 (en) 1970-02-26

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