CH609331A5 - Process for the preparation of 3-aryloxy-3-phenyl-propylamines - Google Patents

Process for the preparation of 3-aryloxy-3-phenyl-propylamines

Info

Publication number
CH609331A5
CH609331A5 CH222878A CH222878A CH609331A5 CH 609331 A5 CH609331 A5 CH 609331A5 CH 222878 A CH222878 A CH 222878A CH 222878 A CH222878 A CH 222878A CH 609331 A5 CH609331 A5 CH 609331A5
Authority
CH
Switzerland
Prior art keywords
formula
denote
compounds
acid addition
propylamines
Prior art date
Application number
CH222878A
Inventor
Bryan Barnet Molloy
Klaus Kurt Schmiegel
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/432,379 external-priority patent/US4314081A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Priority claimed from KR1019750000261A external-priority patent/KR800001009B1/en
Publication of CH609331A5 publication Critical patent/CH609331A5/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline

Abstract

Compounds of the annexed formula I <IMAGE> are prepared in which every R1 and R2 independently of one another represents hydrogen or methyl, R3 and R4 represent halogen, -CF3, C2-C4-alkyl, C1-C3-alkoxy or C3-C4-alkenyl and n and m represent 0, 1 or 2, but where the sum of n and m is not 0 if both R1 denote CH3 and both R2 denote H, and their acid addition salts with pharmaceutically acceptable acids. To do this, the appropriate optionally substituted 3-chloro-1-phenoxy-1-phenylpropane is reacted with ammonia or an amine of the formula NHR1R1 and the compound obtained is optionally converted into its acid addition salt. The compounds of the formula I can be used as psychotropic agents, in particular as antidepressants.
CH222878A 1974-01-10 1975-01-07 Process for the preparation of 3-aryloxy-3-phenyl-propylamines CH609331A5 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US05/432,379 US4314081A (en) 1974-01-10 1974-01-10 Arloxyphenylpropylamines
CH10275A CH609675A5 (en) 1974-01-10 1975-01-07
KR1019750000261A KR800001009B1 (en) 1975-01-09 1975-01-09 Process for the preparation of aryloxy phenyl-propylamines

Publications (1)

Publication Number Publication Date
CH609331A5 true CH609331A5 (en) 1979-02-28

Family

ID=27171785

Family Applications (2)

Application Number Title Priority Date Filing Date
CH222978A CH609332A5 (en) 1974-01-10 1975-01-07 Process for the preparation of novel 3-aryloxy-3-phenyl-propylamines
CH222878A CH609331A5 (en) 1974-01-10 1975-01-07 Process for the preparation of 3-aryloxy-3-phenyl-propylamines

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CH222978A CH609332A5 (en) 1974-01-10 1975-01-07 Process for the preparation of novel 3-aryloxy-3-phenyl-propylamines

Country Status (1)

Country Link
CH (2) CH609332A5 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0318727A2 (en) * 1987-12-01 1989-06-07 Novo Nordisk A/S Aryloxphenylpropylamines and their preparation and use
EP0399504A2 (en) * 1989-05-26 1990-11-28 Novo Nordisk A/S Aryloxyphenylpropylamines their preparation and use

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0318727A2 (en) * 1987-12-01 1989-06-07 Novo Nordisk A/S Aryloxphenylpropylamines and their preparation and use
EP0318727A3 (en) * 1987-12-01 1990-09-12 A/S Ferrosan Aryloxphenylpropylamines and their preparation and use
EP0399504A2 (en) * 1989-05-26 1990-11-28 Novo Nordisk A/S Aryloxyphenylpropylamines their preparation and use
EP0399504A3 (en) * 1989-05-26 1992-02-12 Novo Nordisk A/S Aryloxyphenylpropylamines their preparation and use

Also Published As

Publication number Publication date
CH609332A5 (en) 1979-02-28

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Legal Events

Date Code Title Description
PL Patent ceased