ES301524A1 - Procedure for the preparation of antivirus compositions in a unit dosage form (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of antivirus compositions in a unit dosage form (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES301524A1
ES301524A1 ES301524A ES301524A ES301524A1 ES 301524 A1 ES301524 A1 ES 301524A1 ES 301524 A ES301524 A ES 301524A ES 301524 A ES301524 A ES 301524A ES 301524 A1 ES301524 A1 ES 301524A1
Authority
ES
Spain
Prior art keywords
group
see formula
lower alkyl
hydrogen
translation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES301524A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of ES301524A1 publication Critical patent/ES301524A1/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Method for preparing anti-virus compositions in unit dosage form, characterized in that it comprises adding a suitable pharmaceutical carrier in an amount comprised between 0.05 and 2 g of a substituted piperazine of the general formula ** (See formula) ** wherein R is hydrogen lower alkyl, lower alkenyl or COOR ', where R' is a lower alkyl group; R1 and R2 are hydrogen or lower alkyl; B is the group (see formula), where R3 and R4 are hydrogen, lower alkyl or lower aralkyl, or R3 and R4 are linked together to form a substituted or unsubstituted heterocyclic group, with the nitrogen atom, this ring containing one or two heterogeneous atoms, and B can also be ** (See formula) ** A is a lower alkylene group ** (See formula) ** or the group -CO-ZX, with Z oxygen-sulfur and X being a linear or branched lower alkylene group, and the active compound is generally prepared by the reaction of 1-carbethoxy-4-lower alkylpiperazine, with a lower alkanol alkylamino -inferior, with suitable acids, separating the salts obtained by filtering the precipitate. (Machine-translation by Google Translate, not legally binding)
ES301524A 1963-06-28 1964-06-27 Procedure for the preparation of antivirus compositions in a unit dosage form (Machine-translation by Google Translate, not legally binding) Expired ES301524A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US291282A US3274054A (en) 1963-06-28 1963-06-28 Antiviral compositions and method of administration
US301194A US3213097A (en) 1963-06-28 1963-08-09 4-(3'-dimethylaminopropyl)-1-carbalkoxy piperazine derivatives

Publications (1)

Publication Number Publication Date
ES301524A1 true ES301524A1 (en) 1962-12-16

Family

ID=26966687

Family Applications (1)

Application Number Title Priority Date Filing Date
ES301524A Expired ES301524A1 (en) 1963-06-28 1964-06-27 Procedure for the preparation of antivirus compositions in a unit dosage form (Machine-translation by Google Translate, not legally binding)

Country Status (4)

Country Link
US (2) US3274054A (en)
BE (1) BE647594A (en)
ES (1) ES301524A1 (en)
NL (1) NL6405988A (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR150M (en) * 1963-07-24 1961-01-20 Corbiere Et Pansements Brevete New product with local anesthetic action.
US3458515A (en) * 1966-07-21 1969-07-29 American Home Prod Piperazine substituted pyrroles
FR2081564A1 (en) * 1970-03-05 1971-12-10 Delalande Sa N-amino carbonyl-piperazines analgesics - antiinflammatories ,hypotensives and spasmolytics
US4977156A (en) * 1988-07-26 1990-12-11 The Dow Chemical Company Amino piperazine esters showing biocidal activity

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA547981A (en) * 1957-10-29 L. Bach Frederick Substituted piperazines and method of preparing the same
US2541584A (en) * 1947-06-11 1951-02-13 Nat Aluminate Corp N-acylated piperazines
US2753350A (en) * 1951-11-01 1956-07-03 Hasselstrom Torsten Pungent-tasting pentavalent piperazine diacid salts
US2710824A (en) * 1952-09-17 1955-06-14 Schenley Ind Inc Fungicidal compounds
US2710823A (en) * 1952-09-17 1955-06-14 Schenley Ind Inc Fungicidal compounds
US2794804A (en) * 1955-03-24 1957-06-04 American Cyanamid Co Substituted piperazines and method of preparing the same
US3015657A (en) * 1959-05-28 1962-01-02 Charles F Geschickter 1-carbalkoxy-4-(aminoalkanol) piperazines

Also Published As

Publication number Publication date
BE647594A (en) 1964-11-06
US3213097A (en) 1965-10-19
NL6405988A (en) 1964-12-29
US3274054A (en) 1966-09-20

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