JPS55151547A - Production of guanidinocapronic ester - Google Patents
Production of guanidinocapronic esterInfo
- Publication number
- JPS55151547A JPS55151547A JP5800879A JP5800879A JPS55151547A JP S55151547 A JPS55151547 A JP S55151547A JP 5800879 A JP5800879 A JP 5800879A JP 5800879 A JP5800879 A JP 5800879A JP S55151547 A JPS55151547 A JP S55151547A
- Authority
- JP
- Japan
- Prior art keywords
- ester
- formula
- reaction
- halogen
- employed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: The reaction between an ε-aminocaproic ester and an amidine derivative gives high-purity title compound useful as a medicine because of its antikallikrein activity by simple operations in high yield.
CONSTITUTION: An ε-aminocaroic ester of formula I (R is alkyl, aryl, aralkyl, which may be substituted) and a halogen formamidine of formula II (X is halogen) are made to react to form the objective compound of formula III. The solvent, which is employed for the reaction, is preferably water or an organic solvent such as methanol or acetone. The reaction temperature is preferably 20W60°C. The catalyst is unessential but an inorganic alkali or organic amine may be employed.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5800879A JPS5825662B2 (en) | 1979-05-14 | 1979-05-14 | Production method of guanidinocaproic acid ester |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5800879A JPS5825662B2 (en) | 1979-05-14 | 1979-05-14 | Production method of guanidinocaproic acid ester |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS55151547A true JPS55151547A (en) | 1980-11-26 |
JPS5825662B2 JPS5825662B2 (en) | 1983-05-28 |
Family
ID=13071935
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5800879A Expired JPS5825662B2 (en) | 1979-05-14 | 1979-05-14 | Production method of guanidinocaproic acid ester |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5825662B2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0915084A3 (en) * | 1997-11-04 | 1999-12-08 | Basf Aktiengesellschaft | Process for the preparation of substituted guanidine derivatives |
-
1979
- 1979-05-14 JP JP5800879A patent/JPS5825662B2/en not_active Expired
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0915084A3 (en) * | 1997-11-04 | 1999-12-08 | Basf Aktiengesellschaft | Process for the preparation of substituted guanidine derivatives |
CN1077569C (en) * | 1997-11-04 | 2002-01-09 | Basf公司 | The preparation of substituted guanidine derivatives |
Also Published As
Publication number | Publication date |
---|---|
JPS5825662B2 (en) | 1983-05-28 |
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