JPS55151548A - Production of guanidinocaproic ester - Google Patents

Production of guanidinocaproic ester

Info

Publication number
JPS55151548A
JPS55151548A JP5800979A JP5800979A JPS55151548A JP S55151548 A JPS55151548 A JP S55151548A JP 5800979 A JP5800979 A JP 5800979A JP 5800979 A JP5800979 A JP 5800979A JP S55151548 A JPS55151548 A JP S55151548A
Authority
JP
Japan
Prior art keywords
acid
formula
substituted
ester
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP5800979A
Other languages
Japanese (ja)
Other versions
JPS5825663B2 (en
Inventor
Kiyonori Yokogoshi
Kunio Nagata
Michio Watanabe
Makoto Nishimura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PAAMAKEMU ASIA KK
Permachem Asia Ltd
Original Assignee
PAAMAKEMU ASIA KK
Permachem Asia Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PAAMAKEMU ASIA KK, Permachem Asia Ltd filed Critical PAAMAKEMU ASIA KK
Priority to JP5800979A priority Critical patent/JPS5825663B2/en
Publication of JPS55151548A publication Critical patent/JPS55151548A/en
Publication of JPS5825663B2 publication Critical patent/JPS5825663B2/en
Expired legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: The reaction of an ε-aminocaproic ester with an O-substituted isourea is effected in the presence of water or an organic solvent to form high-purity title compound useful as a medicine with antikallikrein activity with econimical advantage in high yield.
CONSTITUTION: The reaction between an ε-aminocaproic ester of formula I (R is alkyl, aryl, aralkyl, which may be substituted) and an O-substituted isourea of formula II (R1 is the same as R or alkylene) is conducted in water or an organic solvent such as methanol, acetone, benzene or so, preferably at 30W60°C for 1W24hr, to form the compound of formula III. The conversion of the product into the acid adduct with an inorganic acid such as hydrochloric or nitric acid or organic acid such as benzenesulfonic or oxalic acid facilitates the separation and purification.
COPYRIGHT: (C)1980,JPO&Japio
JP5800979A 1979-05-14 1979-05-14 Production method of guanidinocaproic acid ester Expired JPS5825663B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5800979A JPS5825663B2 (en) 1979-05-14 1979-05-14 Production method of guanidinocaproic acid ester

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5800979A JPS5825663B2 (en) 1979-05-14 1979-05-14 Production method of guanidinocaproic acid ester

Publications (2)

Publication Number Publication Date
JPS55151548A true JPS55151548A (en) 1980-11-26
JPS5825663B2 JPS5825663B2 (en) 1983-05-28

Family

ID=13071962

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5800979A Expired JPS5825663B2 (en) 1979-05-14 1979-05-14 Production method of guanidinocaproic acid ester

Country Status (1)

Country Link
JP (1) JPS5825663B2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0915085A2 (en) * 1997-11-04 1999-05-12 Basf Aktiengesellschaft Process for the preparation of substituted guanidine derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0915085A2 (en) * 1997-11-04 1999-05-12 Basf Aktiengesellschaft Process for the preparation of substituted guanidine derivatives
EP0915085A3 (en) * 1997-11-04 1999-12-08 Basf Aktiengesellschaft Process for the preparation of substituted guanidine derivatives

Also Published As

Publication number Publication date
JPS5825663B2 (en) 1983-05-28

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