JPS5576863A - Preparation of 2-chloronicotinic acid - Google Patents
Preparation of 2-chloronicotinic acidInfo
- Publication number
- JPS5576863A JPS5576863A JP15179578A JP15179578A JPS5576863A JP S5576863 A JPS5576863 A JP S5576863A JP 15179578 A JP15179578 A JP 15179578A JP 15179578 A JP15179578 A JP 15179578A JP S5576863 A JPS5576863 A JP S5576863A
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- pentadienoate
- cyano
- methoxy
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To obtain the title compound useful as an intermediate for the synthesis of medicines in high yield, by hydrolyzing the reaction product of a methyl 2-cyano- 5-methoxy-2, 4-pentadienoate with hydrogen chloride in acetic acid.
CONSTITUTION: A compound of formula I: (R1 and R2 are lower alkyl groups), e.g. methyl 2-cyano-5-methoxy-2, 4-pentadienoate is dissolved in acetic acid at 0W30°C, and reacted with hydrogen chloride for 20W100hr to give a compound of formula II, e.g. methyl 2-chloronicotinate, which is hydrolyzed in an aqueous solvent, preferably an aqueous alkali, to form 2-chloronicotinic acid.
EFFECT: Free from toxicity to human bodies and danger, simple industrial operations, and economic advantages compared with the conventional methods.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15179578A JPS5576863A (en) | 1978-12-06 | 1978-12-06 | Preparation of 2-chloronicotinic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15179578A JPS5576863A (en) | 1978-12-06 | 1978-12-06 | Preparation of 2-chloronicotinic acid |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5576863A true JPS5576863A (en) | 1980-06-10 |
Family
ID=15526456
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15179578A Pending JPS5576863A (en) | 1978-12-06 | 1978-12-06 | Preparation of 2-chloronicotinic acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5576863A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0372654A2 (en) * | 1988-12-05 | 1990-06-13 | Shell Internationale Researchmaatschappij B.V. | Preparation of 2-chloropyridine 3-carboxylic acid esters |
-
1978
- 1978-12-06 JP JP15179578A patent/JPS5576863A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0372654A2 (en) * | 1988-12-05 | 1990-06-13 | Shell Internationale Researchmaatschappij B.V. | Preparation of 2-chloropyridine 3-carboxylic acid esters |
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