JPS5576863A - Preparation of 2-chloronicotinic acid - Google Patents

Preparation of 2-chloronicotinic acid

Info

Publication number
JPS5576863A
JPS5576863A JP15179578A JP15179578A JPS5576863A JP S5576863 A JPS5576863 A JP S5576863A JP 15179578 A JP15179578 A JP 15179578A JP 15179578 A JP15179578 A JP 15179578A JP S5576863 A JPS5576863 A JP S5576863A
Authority
JP
Japan
Prior art keywords
methyl
pentadienoate
cyano
methoxy
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP15179578A
Other languages
Japanese (ja)
Inventor
Hiroshi Matsuo
Toshiharu Sakuragi
Mineo Tsuruta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Welfide Corp
Original Assignee
Welfide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Welfide Corp filed Critical Welfide Corp
Priority to JP15179578A priority Critical patent/JPS5576863A/en
Publication of JPS5576863A publication Critical patent/JPS5576863A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To obtain the title compound useful as an intermediate for the synthesis of medicines in high yield, by hydrolyzing the reaction product of a methyl 2-cyano- 5-methoxy-2, 4-pentadienoate with hydrogen chloride in acetic acid.
CONSTITUTION: A compound of formula I: (R1 and R2 are lower alkyl groups), e.g. methyl 2-cyano-5-methoxy-2, 4-pentadienoate is dissolved in acetic acid at 0W30°C, and reacted with hydrogen chloride for 20W100hr to give a compound of formula II, e.g. methyl 2-chloronicotinate, which is hydrolyzed in an aqueous solvent, preferably an aqueous alkali, to form 2-chloronicotinic acid.
EFFECT: Free from toxicity to human bodies and danger, simple industrial operations, and economic advantages compared with the conventional methods.
COPYRIGHT: (C)1980,JPO&Japio
JP15179578A 1978-12-06 1978-12-06 Preparation of 2-chloronicotinic acid Pending JPS5576863A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15179578A JPS5576863A (en) 1978-12-06 1978-12-06 Preparation of 2-chloronicotinic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15179578A JPS5576863A (en) 1978-12-06 1978-12-06 Preparation of 2-chloronicotinic acid

Publications (1)

Publication Number Publication Date
JPS5576863A true JPS5576863A (en) 1980-06-10

Family

ID=15526456

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15179578A Pending JPS5576863A (en) 1978-12-06 1978-12-06 Preparation of 2-chloronicotinic acid

Country Status (1)

Country Link
JP (1) JPS5576863A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0372654A2 (en) * 1988-12-05 1990-06-13 Shell Internationale Researchmaatschappij B.V. Preparation of 2-chloropyridine 3-carboxylic acid esters

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0372654A2 (en) * 1988-12-05 1990-06-13 Shell Internationale Researchmaatschappij B.V. Preparation of 2-chloropyridine 3-carboxylic acid esters

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