JPS55157572A - Preparation of 2-mercapto-4,6-dimethylpyrimidine hydrochloride - Google Patents
Preparation of 2-mercapto-4,6-dimethylpyrimidine hydrochlorideInfo
- Publication number
- JPS55157572A JPS55157572A JP6477879A JP6477879A JPS55157572A JP S55157572 A JPS55157572 A JP S55157572A JP 6477879 A JP6477879 A JP 6477879A JP 6477879 A JP6477879 A JP 6477879A JP S55157572 A JPS55157572 A JP S55157572A
- Authority
- JP
- Japan
- Prior art keywords
- hydrochloric acid
- mercapto
- preparation
- acethylacetone
- thiourea
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain the title high-purity compound useful as an N-protecting agent in peptide synthesis, by reacting acethylacetone with thiourea in the presence of hydrochloric acid as a catalyst in water as a solvent.
CONSTITUTION: Acethylacetone and htiourea are dissolved in water under heating, and hydrochloric acid as a catalyst is added dropwise to the solution at 30W100°C, preferably 40W60°C. The mixture is then reacted for 2W24hr to give the objective compound. The amount of the thiourea is 0.8W1.2mol, preferably 0.95W1.05mol, based on 1.0mol of the acetylacetone, and the amount of the hydrochloric acid is 1.0W6.0mol, preferably 1.0W3.0mol.
USE: An active ester for peptide synthesis or a metal corrosion inhibitor.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6477879A JPS55157572A (en) | 1979-05-25 | 1979-05-25 | Preparation of 2-mercapto-4,6-dimethylpyrimidine hydrochloride |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6477879A JPS55157572A (en) | 1979-05-25 | 1979-05-25 | Preparation of 2-mercapto-4,6-dimethylpyrimidine hydrochloride |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS55157572A true JPS55157572A (en) | 1980-12-08 |
JPS6144870B2 JPS6144870B2 (en) | 1986-10-04 |
Family
ID=13267998
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6477879A Granted JPS55157572A (en) | 1979-05-25 | 1979-05-25 | Preparation of 2-mercapto-4,6-dimethylpyrimidine hydrochloride |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55157572A (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4836180A (en) * | 1971-09-17 | 1973-05-28 | ||
JPS54112881A (en) * | 1978-02-22 | 1979-09-04 | Mitsubishi Chem Ind Ltd | Preparation of 2-mercaptopyrimidine hydrochloride |
-
1979
- 1979-05-25 JP JP6477879A patent/JPS55157572A/en active Granted
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4836180A (en) * | 1971-09-17 | 1973-05-28 | ||
JPS54112881A (en) * | 1978-02-22 | 1979-09-04 | Mitsubishi Chem Ind Ltd | Preparation of 2-mercaptopyrimidine hydrochloride |
Also Published As
Publication number | Publication date |
---|---|
JPS6144870B2 (en) | 1986-10-04 |
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