JPS5626838A - Preparation of propionic acid derivative - Google Patents

Preparation of propionic acid derivative

Info

Publication number
JPS5626838A
JPS5626838A JP10240179A JP10240179A JPS5626838A JP S5626838 A JPS5626838 A JP S5626838A JP 10240179 A JP10240179 A JP 10240179A JP 10240179 A JP10240179 A JP 10240179A JP S5626838 A JPS5626838 A JP S5626838A
Authority
JP
Japan
Prior art keywords
formula
reaction
propionic acid
compound
sulfur
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10240179A
Other languages
Japanese (ja)
Inventor
Jun Uno
Yasutaka Nagai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dainippon Pharmaceutical Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Priority to JP10240179A priority Critical patent/JPS5626838A/en
Publication of JPS5626838A publication Critical patent/JPS5626838A/en
Pending legal-status Critical Current

Links

Landscapes

  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain the titled compound useful as an anti-inflammatory agent, industrially and advantageously, by the reaction of a novel propionic acid ester derivative with sulfur and a secondary amine, and the subsequent hydrolysis and then the cyclization of the hydrolysis product in the presence of a condensing agent.
CONSTITUTION: A novel compound of formula I (Z is O or S; R1 is lower alkyl) is reacted with sulfur and a secondary amine of formula II (R2 and R3 are lower alkyls or a heterocyclic ring with the N adjacent), for example, under the usual Willgerodt-Kindler reaction conditions, to prepare the compound of formula III, which is hydrolyzed by the conventional method to give a dicarboxylic acid of formula IV. The resulting compound is cyclized in the presence of a condensing agent, e.g. polyphosphoric acid, which is applied to the intramolcular acylation, to give a propionic acid derivative of formula V. This reaction is suitable for an industrial process because of high yield and less reaction stages than the conventional ones and no dangerous reaction.
COPYRIGHT: (C)1981,JPO&Japio
JP10240179A 1979-08-10 1979-08-10 Preparation of propionic acid derivative Pending JPS5626838A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10240179A JPS5626838A (en) 1979-08-10 1979-08-10 Preparation of propionic acid derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10240179A JPS5626838A (en) 1979-08-10 1979-08-10 Preparation of propionic acid derivative

Publications (1)

Publication Number Publication Date
JPS5626838A true JPS5626838A (en) 1981-03-16

Family

ID=14326415

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10240179A Pending JPS5626838A (en) 1979-08-10 1979-08-10 Preparation of propionic acid derivative

Country Status (1)

Country Link
JP (1) JPS5626838A (en)

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