JPS5626838A - Preparation of propionic acid derivative - Google Patents
Preparation of propionic acid derivativeInfo
- Publication number
- JPS5626838A JPS5626838A JP10240179A JP10240179A JPS5626838A JP S5626838 A JPS5626838 A JP S5626838A JP 10240179 A JP10240179 A JP 10240179A JP 10240179 A JP10240179 A JP 10240179A JP S5626838 A JPS5626838 A JP S5626838A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- reaction
- propionic acid
- compound
- sulfur
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain the titled compound useful as an anti-inflammatory agent, industrially and advantageously, by the reaction of a novel propionic acid ester derivative with sulfur and a secondary amine, and the subsequent hydrolysis and then the cyclization of the hydrolysis product in the presence of a condensing agent.
CONSTITUTION: A novel compound of formula I (Z is O or S; R1 is lower alkyl) is reacted with sulfur and a secondary amine of formula II (R2 and R3 are lower alkyls or a heterocyclic ring with the N adjacent), for example, under the usual Willgerodt-Kindler reaction conditions, to prepare the compound of formula III, which is hydrolyzed by the conventional method to give a dicarboxylic acid of formula IV. The resulting compound is cyclized in the presence of a condensing agent, e.g. polyphosphoric acid, which is applied to the intramolcular acylation, to give a propionic acid derivative of formula V. This reaction is suitable for an industrial process because of high yield and less reaction stages than the conventional ones and no dangerous reaction.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10240179A JPS5626838A (en) | 1979-08-10 | 1979-08-10 | Preparation of propionic acid derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10240179A JPS5626838A (en) | 1979-08-10 | 1979-08-10 | Preparation of propionic acid derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5626838A true JPS5626838A (en) | 1981-03-16 |
Family
ID=14326415
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10240179A Pending JPS5626838A (en) | 1979-08-10 | 1979-08-10 | Preparation of propionic acid derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5626838A (en) |
-
1979
- 1979-08-10 JP JP10240179A patent/JPS5626838A/en active Pending
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS55164686A (en) | Novel maytansinoid compound and its preparation | |
JPS5762259A (en) | Preparation of substituted quinolinecarboxylic acid derivative | |
JPS54119494A (en) | Preparation of cephalosporin compound | |
ES8609195A1 (en) | Process for preparing anti-inflammatory cycloalkylidenemethylphenylacetic acid derivatives. | |
JPS5626838A (en) | Preparation of propionic acid derivative | |
ES8200681A1 (en) | Process for preparing derivatives of 5,11-dihydro-6h-pyrido[2,3-b][1,4]-benzodiazepin-6-one, and the final derivatives and synthesis intermediates obtained thereby | |
JPS55133355A (en) | Inversion of 3-amino group of beta-lactam ring | |
JPS557222A (en) | Preparation of aletheine derivative | |
JPS55151555A (en) | Proline derivatives and their production | |
JPS5758689A (en) | Novel preparation of 7-substituted or unsubstituted amino-3-substituted methylcephem carboxylic acids | |
JPS5657734A (en) | Novel preparation of 4-acyloxy-beta-ionone | |
JPS57154164A (en) | Preparation of dl-cysteine or cystine | |
JPS55102584A (en) | Preparation of alpha-sulfobenzylpenicilin and its salt | |
JPS5538347A (en) | Preparation of indazoleacetic acids | |
JPS5576888A (en) | Bicyclic hetero compound and its preparation | |
JPS5780367A (en) | Preparation of tryptophan and its derivative | |
JPS5649337A (en) | Dibenzo a,d cycloheptene derivative and its preparation | |
JPS55111468A (en) | Preparation of n-benzyl-tetrahydro isoquinoline derivative | |
JPS5746951A (en) | Production of 2-amino-4-cyanobutyric derivative | |
BR8206537A (en) | PROCESS FOR THE PREPARATION OF CARBOXYLIC ACID ANHYDRATES | |
JPS5686142A (en) | Preparation of threo-3-amino-2-hydroxybutanoylamino- acetic acids | |
YU42489A (en) | Process for obtaining esther derivatives of phtalazinocetic acid and new intermediate | |
RU92008707A (en) | METHOD FOR OBTAINING OXOCHROME | |
JPS5692290A (en) | Preparation of 7-amino-3-substituted methylcephem carboxylic acid, its salt or ester | |
JPS5492947A (en) | Production of bicyclo10.3.0pentadeca-1(12)-ene-13-one |