JPS56140961A - Preparation of sulfonate of p-ethoxycarbonylphenyl epsilon-guanidinocaproate - Google Patents
Preparation of sulfonate of p-ethoxycarbonylphenyl epsilon-guanidinocaproateInfo
- Publication number
- JPS56140961A JPS56140961A JP4443780A JP4443780A JPS56140961A JP S56140961 A JPS56140961 A JP S56140961A JP 4443780 A JP4443780 A JP 4443780A JP 4443780 A JP4443780 A JP 4443780A JP S56140961 A JPS56140961 A JP S56140961A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- sulfonyl chloride
- sulfonate
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain the titled compound useful as anticallicrein agent in one stage in high yield, by reacting a specific compound with a sulfonyl chloride in the presence of an acid acceptor.
CONSTITUTION: A sulfonate of ε-guanidinocaproic acid expressed by formula II (R is p-methylphenyl, etc.) and ethyl p-hydroxybenzoate of formula III are dissolved in an intert solvent, e.g. DMF, and a sulfonyl chloride of formula IV and an acid acceptor are added thereto and reacted at room temperature for about 1hr to give a compound of formula I. The sulfonyl chloride is used in an amount equimolar or more with the compound of formula II. Pyridine, etc. may be preferred as the acid acceptor.
EFFECT: Expensive acid-resistant apparatuses are not required without causing pollution problems.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4443780A JPS56140961A (en) | 1980-04-04 | 1980-04-04 | Preparation of sulfonate of p-ethoxycarbonylphenyl epsilon-guanidinocaproate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4443780A JPS56140961A (en) | 1980-04-04 | 1980-04-04 | Preparation of sulfonate of p-ethoxycarbonylphenyl epsilon-guanidinocaproate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS56140961A true JPS56140961A (en) | 1981-11-04 |
Family
ID=12691460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4443780A Pending JPS56140961A (en) | 1980-04-04 | 1980-04-04 | Preparation of sulfonate of p-ethoxycarbonylphenyl epsilon-guanidinocaproate |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS56140961A (en) |
-
1980
- 1980-04-04 JP JP4443780A patent/JPS56140961A/en active Pending
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