JPS5581861A - Nicotinamide derivative - Google Patents
Nicotinamide derivativeInfo
- Publication number
- JPS5581861A JPS5581861A JP15413278A JP15413278A JPS5581861A JP S5581861 A JPS5581861 A JP S5581861A JP 15413278 A JP15413278 A JP 15413278A JP 15413278 A JP15413278 A JP 15413278A JP S5581861 A JPS5581861 A JP S5581861A
- Authority
- JP
- Japan
- Prior art keywords
- pyridine
- solvent
- nicotinamide derivative
- bisnicotinamidopropane
- diaminoalkane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A nicotinamide derivative of the formula (R is 3W12C alkylene).
EXAMPLE: 1,3-Bisnicotinamidopropane.
USE: Useful as a medicine having antiinflammatory activity and preventive activity against arachidonic acid-induced thrombosis.
PREPARATION: An α-or ω-diaminoalkane is reacted with a halogenide of nicotinic acid, in a solvent, e.g. water, pyridine, or THF, not at a specific but at a reasonably selected temperature between low and reflux temperature of the solvent, preferably in the presence of a basic compound, e.g. pyridine or Na2CO3, as a reaction assistant, to obtain the title compound.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15413278A JPS5581861A (en) | 1978-12-15 | 1978-12-15 | Nicotinamide derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15413278A JPS5581861A (en) | 1978-12-15 | 1978-12-15 | Nicotinamide derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5581861A true JPS5581861A (en) | 1980-06-20 |
Family
ID=15577587
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15413278A Pending JPS5581861A (en) | 1978-12-15 | 1978-12-15 | Nicotinamide derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5581861A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4994462A (en) * | 1982-04-15 | 1991-02-19 | Research Corporation | Platelet aggregation inhibitory agents and intermediate therefor |
WO1997035577A1 (en) * | 1996-03-22 | 1997-10-02 | Chugai Seiyaku Kabushiki Kaisha | Remedy for spinal injury |
-
1978
- 1978-12-15 JP JP15413278A patent/JPS5581861A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4994462A (en) * | 1982-04-15 | 1991-02-19 | Research Corporation | Platelet aggregation inhibitory agents and intermediate therefor |
WO1997035577A1 (en) * | 1996-03-22 | 1997-10-02 | Chugai Seiyaku Kabushiki Kaisha | Remedy for spinal injury |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS5432460A (en) | Cycloalkylidenemethylphenylacetic acid derivative and their preparation | |
JPS5581861A (en) | Nicotinamide derivative | |
JPS55162763A (en) | Perfluoroalkyl compound and its preparation | |
JPS5583791A (en) | 7-methoxycephalosporin derivative and its preparation | |
JPS52131544A (en) | Phenoxymalonic acid derivatives and herbicides containing them | |
JPS56113744A (en) | Benzoate derivative, its preparation, and use of said derivative | |
JPS5735556A (en) | Preparation of guanidinomethylcyclohexanecarboxylic acid ester | |
JPS5543027A (en) | 2-pyridyl-1-phthalazone derivative | |
JPS5439042A (en) | Preparation of 2-(4-iso butylphenyl)-propionic acid | |
JPS5427546A (en) | Liquid crystal compound | |
JPS55104268A (en) | Preparation of cyclohexanol-2,2,6,6-tetrakis (hydroxymethyl)-tetranicotinate | |
JPS54154736A (en) | 1,4-di(trans-4-n-alkylcyclohexanecarbonyloxy)-2-chlorobenzene | |
JPS5629579A (en) | Preparation of novel cyclic urethane compound | |
JPS562957A (en) | N-adamantylthioamide derivative | |
JPS5242884A (en) | Preparation of 2,3,6-trimethyl hydroquinone-1-nicotinic acid esters | |
JPS55154952A (en) | Amidinophenol derivative | |
JPS5545630A (en) | Preparation of 4-chloropyridine hydrochloride | |
JPS54157546A (en) | Preparation of 3-cyclohexenecarboxylic acid | |
JPS5436257A (en) | Substituted benzoic acid amide | |
JPS5555168A (en) | Novel 4-carboxy-2-phenyl-1-phthalazone derivative | |
JPS5318531A (en) | 2-(alpha-substituted acryloyl) benzoic acid compounds and their preparation | |
JPS54128580A (en) | Sulfonanilide compound and herbicides containing it | |
JPS57193444A (en) | Sulfonate derivative, its preparation and antilipemic agent containing the same | |
JPS5318532A (en) | Preparation of 2-(4-isobutylphenyl) propionic acid | |
JPS5738758A (en) | Substituted benzanilide derivative and germicide containing the same |