JPS5756481A - Production of 1-(5-oxohexyl)-3,7-dimethylxanthine - Google Patents

Production of 1-(5-oxohexyl)-3,7-dimethylxanthine

Info

Publication number
JPS5756481A
JPS5756481A JP13194680A JP13194680A JPS5756481A JP S5756481 A JPS5756481 A JP S5756481A JP 13194680 A JP13194680 A JP 13194680A JP 13194680 A JP13194680 A JP 13194680A JP S5756481 A JPS5756481 A JP S5756481A
Authority
JP
Japan
Prior art keywords
dimethylxanthine
reaction
compound
acetylacetone
alkali
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP13194680A
Other languages
Japanese (ja)
Inventor
Takao Kishimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KAWASHIMA YAKUHIN KAIHATSU KK
Original Assignee
KAWASHIMA YAKUHIN KAIHATSU KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KAWASHIMA YAKUHIN KAIHATSU KK filed Critical KAWASHIMA YAKUHIN KAIHATSU KK
Priority to JP13194680A priority Critical patent/JPS5756481A/en
Publication of JPS5756481A publication Critical patent/JPS5756481A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: A available raw material, 1-(3-sulfonyloxypropyl)-3,7-dimethylxanthine, is used to effect the reaction with acetylacetone in the prepsence of an alkali and a metal iodide to produce the titled substance of high purity used as a vasodilator in high yield.
CONSTITUTION: The reaction between 1-(3-sulfonylxypropyl)-3,7-dimethylxanthine of formulaI(R is lower alkyl, aryl aralkyl) and acetylacetone is conducted in an inert solvent such as dimethylacetamide in the presence of an alkali such as potassium carbonate and a metal iodide such as potassium iodide to give a compound of formula II. The starting material, the compound of formula I, is readily obtained, e.g., by reaction of 1-(3-hydroxypropyl)-3,7-dimethylxanthine with a compound of R-SO2Cl.
COPYRIGHT: (C)1982,JPO&Japio
JP13194680A 1980-09-22 1980-09-22 Production of 1-(5-oxohexyl)-3,7-dimethylxanthine Pending JPS5756481A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13194680A JPS5756481A (en) 1980-09-22 1980-09-22 Production of 1-(5-oxohexyl)-3,7-dimethylxanthine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13194680A JPS5756481A (en) 1980-09-22 1980-09-22 Production of 1-(5-oxohexyl)-3,7-dimethylxanthine

Publications (1)

Publication Number Publication Date
JPS5756481A true JPS5756481A (en) 1982-04-05

Family

ID=15069898

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13194680A Pending JPS5756481A (en) 1980-09-22 1980-09-22 Production of 1-(5-oxohexyl)-3,7-dimethylxanthine

Country Status (1)

Country Link
JP (1) JPS5756481A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011028835A1 (en) 2009-09-02 2011-03-10 Concert Pharmaceuticals, Inc. Substituted xanthine derivatives
WO2013155465A1 (en) 2012-04-13 2013-10-17 Concert Pharmaceuticals, Inc. Substituted xanthine derivatives
EP3199203A1 (en) 2008-02-29 2017-08-02 Concert Pharmaceuticals Inc. Substitued xanthine derivatives

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5632477A (en) * 1979-08-27 1981-04-01 Nippon Iyakuhin Kaihatsu Kenkyusho:Kk Preparation of 1- 5-oxohexyl -3,7-dimethylxanthine

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5632477A (en) * 1979-08-27 1981-04-01 Nippon Iyakuhin Kaihatsu Kenkyusho:Kk Preparation of 1- 5-oxohexyl -3,7-dimethylxanthine

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3199203A1 (en) 2008-02-29 2017-08-02 Concert Pharmaceuticals Inc. Substitued xanthine derivatives
WO2011028835A1 (en) 2009-09-02 2011-03-10 Concert Pharmaceuticals, Inc. Substituted xanthine derivatives
WO2013155465A1 (en) 2012-04-13 2013-10-17 Concert Pharmaceuticals, Inc. Substituted xanthine derivatives

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