JPS5576877A - Preparation of 1-(5-oxohexyl)-3,7-dialkylxanthine - Google Patents
Preparation of 1-(5-oxohexyl)-3,7-dialkylxanthineInfo
- Publication number
- JPS5576877A JPS5576877A JP15129578A JP15129578A JPS5576877A JP S5576877 A JPS5576877 A JP S5576877A JP 15129578 A JP15129578 A JP 15129578A JP 15129578 A JP15129578 A JP 15129578A JP S5576877 A JPS5576877 A JP S5576877A
- Authority
- JP
- Japan
- Prior art keywords
- dialkylxanthine
- oxohexyl
- alkali metal
- sulfonic acid
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To obtain the title compound useful as a vasodilator industrially advantageously and economically in high yield, by reacting an alkali metal salt of a 3, 7-dialkylxanthine with low-priced sulfonic acid-5-oxohexyl ester.
CONSTITUTION: An alkali metal salt of 3,7-dialkylxanthine shown by the formula II (R1 is 2W12C alkyl; M is alkali metal) is reacted with a sulfonic acid-5-oxohexyl ester shown by the formula III (R is alkyl, aryl, or aralkyl capable of having a substituent group) obtainable at low price in a proper inert solvent or in the absence of a solvent preferably at 50W150°C, especially at 60W120°C in a stoichiometric quantity to give a 1-(5-oxohexyl)-3,7-dialkylxanthine shown by the formual I in a high yield of approximately not less than 90%. Sulfonic acid produced as a by-product is recovered, being used as a starting material of the compound shown by the formula III.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15129578A JPS5576877A (en) | 1978-12-06 | 1978-12-06 | Preparation of 1-(5-oxohexyl)-3,7-dialkylxanthine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15129578A JPS5576877A (en) | 1978-12-06 | 1978-12-06 | Preparation of 1-(5-oxohexyl)-3,7-dialkylxanthine |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5576877A true JPS5576877A (en) | 1980-06-10 |
Family
ID=15515552
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15129578A Pending JPS5576877A (en) | 1978-12-06 | 1978-12-06 | Preparation of 1-(5-oxohexyl)-3,7-dialkylxanthine |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5576877A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0042706A2 (en) * | 1980-06-21 | 1981-12-30 | BEECHAM - WUELFING GmbH & Co. KG | Xanthine derivatives, pharmaceutical compositions containing them and a process for their preparation |
-
1978
- 1978-12-06 JP JP15129578A patent/JPS5576877A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0042706A2 (en) * | 1980-06-21 | 1981-12-30 | BEECHAM - WUELFING GmbH & Co. KG | Xanthine derivatives, pharmaceutical compositions containing them and a process for their preparation |
EP0157098A1 (en) * | 1980-06-21 | 1985-10-09 | Beecham Wuelfing GmbH & Co KG | Xanthine derivatives, pharmaceuticals compositions containing them and a process for their preparation |
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