JPS5576877A - Preparation of 1-(5-oxohexyl)-3,7-dialkylxanthine - Google Patents

Preparation of 1-(5-oxohexyl)-3,7-dialkylxanthine

Info

Publication number
JPS5576877A
JPS5576877A JP15129578A JP15129578A JPS5576877A JP S5576877 A JPS5576877 A JP S5576877A JP 15129578 A JP15129578 A JP 15129578A JP 15129578 A JP15129578 A JP 15129578A JP S5576877 A JPS5576877 A JP S5576877A
Authority
JP
Japan
Prior art keywords
dialkylxanthine
oxohexyl
alkali metal
sulfonic acid
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP15129578A
Other languages
Japanese (ja)
Inventor
Mitsuhiro Miyagaki
Mikio Hori
Shinshirou Kougo
Motoo Kawahara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SHIRATORI SEIYAKU KK
Shiratori Pharmaceutical Co Ltd
Original Assignee
SHIRATORI SEIYAKU KK
Shiratori Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SHIRATORI SEIYAKU KK, Shiratori Pharmaceutical Co Ltd filed Critical SHIRATORI SEIYAKU KK
Priority to JP15129578A priority Critical patent/JPS5576877A/en
Publication of JPS5576877A publication Critical patent/JPS5576877A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To obtain the title compound useful as a vasodilator industrially advantageously and economically in high yield, by reacting an alkali metal salt of a 3, 7-dialkylxanthine with low-priced sulfonic acid-5-oxohexyl ester.
CONSTITUTION: An alkali metal salt of 3,7-dialkylxanthine shown by the formula II (R1 is 2W12C alkyl; M is alkali metal) is reacted with a sulfonic acid-5-oxohexyl ester shown by the formula III (R is alkyl, aryl, or aralkyl capable of having a substituent group) obtainable at low price in a proper inert solvent or in the absence of a solvent preferably at 50W150°C, especially at 60W120°C in a stoichiometric quantity to give a 1-(5-oxohexyl)-3,7-dialkylxanthine shown by the formual I in a high yield of approximately not less than 90%. Sulfonic acid produced as a by-product is recovered, being used as a starting material of the compound shown by the formula III.
COPYRIGHT: (C)1980,JPO&Japio
JP15129578A 1978-12-06 1978-12-06 Preparation of 1-(5-oxohexyl)-3,7-dialkylxanthine Pending JPS5576877A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15129578A JPS5576877A (en) 1978-12-06 1978-12-06 Preparation of 1-(5-oxohexyl)-3,7-dialkylxanthine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15129578A JPS5576877A (en) 1978-12-06 1978-12-06 Preparation of 1-(5-oxohexyl)-3,7-dialkylxanthine

Publications (1)

Publication Number Publication Date
JPS5576877A true JPS5576877A (en) 1980-06-10

Family

ID=15515552

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15129578A Pending JPS5576877A (en) 1978-12-06 1978-12-06 Preparation of 1-(5-oxohexyl)-3,7-dialkylxanthine

Country Status (1)

Country Link
JP (1) JPS5576877A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0042706A2 (en) * 1980-06-21 1981-12-30 BEECHAM - WUELFING GmbH & Co. KG Xanthine derivatives, pharmaceutical compositions containing them and a process for their preparation

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0042706A2 (en) * 1980-06-21 1981-12-30 BEECHAM - WUELFING GmbH & Co. KG Xanthine derivatives, pharmaceutical compositions containing them and a process for their preparation
EP0157098A1 (en) * 1980-06-21 1985-10-09 Beecham Wuelfing GmbH & Co KG Xanthine derivatives, pharmaceuticals compositions containing them and a process for their preparation

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