JPS5513216A - Preparation of 1-(5-oxohexyl)-3,7-dimethylxanthine - Google Patents

Preparation of 1-(5-oxohexyl)-3,7-dimethylxanthine

Info

Publication number
JPS5513216A
JPS5513216A JP8538278A JP8538278A JPS5513216A JP S5513216 A JPS5513216 A JP S5513216A JP 8538278 A JP8538278 A JP 8538278A JP 8538278 A JP8538278 A JP 8538278A JP S5513216 A JPS5513216 A JP S5513216A
Authority
JP
Japan
Prior art keywords
formula
dimethylxanthine
compound shown
sulfonyloxypropyl
acetoacetate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8538278A
Other languages
Japanese (ja)
Inventor
Mitsuhiro Miyagaki
Mikio Hori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SHIRATORI SEIYAKU KK
Shiratori Pharmaceutical Co Ltd
Original Assignee
SHIRATORI SEIYAKU KK
Shiratori Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SHIRATORI SEIYAKU KK, Shiratori Pharmaceutical Co Ltd filed Critical SHIRATORI SEIYAKU KK
Priority to JP8538278A priority Critical patent/JPS5513216A/en
Publication of JPS5513216A publication Critical patent/JPS5513216A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To prepare the title compound for use as medicines having improved dilation action of blood vessels in high yield, by reacting a low-priced novel 1-(3- sulfonyloxypropyl)-3,7-dimethylxanthine with an acetoacetate.
CONSTITUTION: A 1-(3-sulfonyloxypropyl)-3,7-dimethylxanthine shown by the formula II (R is alkyl, aryl, aralkyl, which may hava a sybstituent group) is reacted with an acetoacetate, and the reaction product is subjected to ketonic decomposition to prepare the desired compound shown by the formula I. The novel compound shown by the formula II is obtained by reacting 1-(3-hydroxypropyl)-3,7-dimethylxanthine with a sulfonyl chloride shown by the formula R1SO2Cl. Sulfonic acid produced as by-products can be recovered and reused as a raw material of the compound shown by the formula II.
COPYRIGHT: (C)1980,JPO&Japio
JP8538278A 1978-07-13 1978-07-13 Preparation of 1-(5-oxohexyl)-3,7-dimethylxanthine Pending JPS5513216A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8538278A JPS5513216A (en) 1978-07-13 1978-07-13 Preparation of 1-(5-oxohexyl)-3,7-dimethylxanthine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8538278A JPS5513216A (en) 1978-07-13 1978-07-13 Preparation of 1-(5-oxohexyl)-3,7-dimethylxanthine

Publications (1)

Publication Number Publication Date
JPS5513216A true JPS5513216A (en) 1980-01-30

Family

ID=13857180

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8538278A Pending JPS5513216A (en) 1978-07-13 1978-07-13 Preparation of 1-(5-oxohexyl)-3,7-dimethylxanthine

Country Status (1)

Country Link
JP (1) JPS5513216A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110627792A (en) * 2019-10-18 2019-12-31 海南顿斯医药科技有限公司 Pentoxifylline compound

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110627792A (en) * 2019-10-18 2019-12-31 海南顿斯医药科技有限公司 Pentoxifylline compound

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