JPS5639087A - Uracil derivative and its preparation - Google Patents
Uracil derivative and its preparationInfo
- Publication number
- JPS5639087A JPS5639087A JP11561179A JP11561179A JPS5639087A JP S5639087 A JPS5639087 A JP S5639087A JP 11561179 A JP11561179 A JP 11561179A JP 11561179 A JP11561179 A JP 11561179A JP S5639087 A JPS5639087 A JP S5639087A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- furanyl
- fluorouracil
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A uracil derivative expressed by formula I (R is lower alkyl or aryl).
EXAMPLE: 1-(3'-Acetoxytetrahydro-2'-furanyl)-5-fluorouracil.
USE: Acarcinostatic agent and a synthetic intermediate therefor.
PROCESS: A 2, 3'-anhydro-1-(tetrahydro-2'-furanyl)-5-fluorouracil of formula II is reacted with an alkali metal salt of an organic acid, e.g. potassium acetate, or an alkali metal halide, e.g. potassium fluoride, and an organic acid, e.g. RCOOH (R is lower alkyl or aryl), in a solvent, e.g. dimethylformamide, at room, temperatureW 250°C to give the compound of formula I. The starting compound of formula II is obtained by dissolving a compound of formula III (X is halogen) in a solvent, e.g. or acetonitrile, and allowing the resultant solution to stand.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11561179A JPS5639087A (en) | 1979-09-07 | 1979-09-07 | Uracil derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11561179A JPS5639087A (en) | 1979-09-07 | 1979-09-07 | Uracil derivative and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5639087A true JPS5639087A (en) | 1981-04-14 |
JPS611031B2 JPS611031B2 (en) | 1986-01-13 |
Family
ID=14666926
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11561179A Granted JPS5639087A (en) | 1979-09-07 | 1979-09-07 | Uracil derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5639087A (en) |
-
1979
- 1979-09-07 JP JP11561179A patent/JPS5639087A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS611031B2 (en) | 1986-01-13 |
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