JPS5461193A - Preparation of 1-(5-oxohexyl)theobromine - Google Patents
Preparation of 1-(5-oxohexyl)theobromineInfo
- Publication number
- JPS5461193A JPS5461193A JP12632777A JP12632777A JPS5461193A JP S5461193 A JPS5461193 A JP S5461193A JP 12632777 A JP12632777 A JP 12632777A JP 12632777 A JP12632777 A JP 12632777A JP S5461193 A JPS5461193 A JP S5461193A
- Authority
- JP
- Japan
- Prior art keywords
- theobromine
- alkali metal
- formula
- hexanone
- reacted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To prepare the title compound usable as a high-purity pharmaceutical in a high yield hygienically, by reacting an alkali metal salt of theobromine with an organic sulfonyl derivative of 6-hydroxy-2-hexanone.
CONSTITUTION: Theobromine of formula I is reacted with an alkali metal compound, e.g. sodium hydride, potassium hydroxide, etc. in an aprotic polar solvent, e.g. dimethylformamide, dimethylacetamide, etc. to form an alkali metal salt of theobromine, which is then reacted with an organic sulfonyl derivative of 6-hydroxyl-2- hexanone of formula II: (R is lower alkyl, unsubstituted or substituted phenyl group) to give 1-(5-oxohexyl)theobromine of formula III.
USE: Remarkable vasodilator and erythrocyte deformability improving actions with little side effects.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12632777A JPS5461193A (en) | 1977-10-20 | 1977-10-20 | Preparation of 1-(5-oxohexyl)theobromine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12632777A JPS5461193A (en) | 1977-10-20 | 1977-10-20 | Preparation of 1-(5-oxohexyl)theobromine |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5461193A true JPS5461193A (en) | 1979-05-17 |
Family
ID=14932434
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12632777A Pending JPS5461193A (en) | 1977-10-20 | 1977-10-20 | Preparation of 1-(5-oxohexyl)theobromine |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5461193A (en) |
-
1977
- 1977-10-20 JP JP12632777A patent/JPS5461193A/en active Pending
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