JPS5461193A - Preparation of 1-(5-oxohexyl)theobromine - Google Patents

Preparation of 1-(5-oxohexyl)theobromine

Info

Publication number
JPS5461193A
JPS5461193A JP12632777A JP12632777A JPS5461193A JP S5461193 A JPS5461193 A JP S5461193A JP 12632777 A JP12632777 A JP 12632777A JP 12632777 A JP12632777 A JP 12632777A JP S5461193 A JPS5461193 A JP S5461193A
Authority
JP
Japan
Prior art keywords
theobromine
alkali metal
formula
hexanone
reacted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP12632777A
Other languages
Japanese (ja)
Inventor
Yukinari Kobayashi
Mikio Wakabayashi
Ryoji Kodaira
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Industry Co Ltd filed Critical Asahi Chemical Industry Co Ltd
Priority to JP12632777A priority Critical patent/JPS5461193A/en
Publication of JPS5461193A publication Critical patent/JPS5461193A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To prepare the title compound usable as a high-purity pharmaceutical in a high yield hygienically, by reacting an alkali metal salt of theobromine with an organic sulfonyl derivative of 6-hydroxy-2-hexanone.
CONSTITUTION: Theobromine of formula I is reacted with an alkali metal compound, e.g. sodium hydride, potassium hydroxide, etc. in an aprotic polar solvent, e.g. dimethylformamide, dimethylacetamide, etc. to form an alkali metal salt of theobromine, which is then reacted with an organic sulfonyl derivative of 6-hydroxyl-2- hexanone of formula II: (R is lower alkyl, unsubstituted or substituted phenyl group) to give 1-(5-oxohexyl)theobromine of formula III.
USE: Remarkable vasodilator and erythrocyte deformability improving actions with little side effects.
COPYRIGHT: (C)1979,JPO&Japio
JP12632777A 1977-10-20 1977-10-20 Preparation of 1-(5-oxohexyl)theobromine Pending JPS5461193A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12632777A JPS5461193A (en) 1977-10-20 1977-10-20 Preparation of 1-(5-oxohexyl)theobromine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12632777A JPS5461193A (en) 1977-10-20 1977-10-20 Preparation of 1-(5-oxohexyl)theobromine

Publications (1)

Publication Number Publication Date
JPS5461193A true JPS5461193A (en) 1979-05-17

Family

ID=14932434

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12632777A Pending JPS5461193A (en) 1977-10-20 1977-10-20 Preparation of 1-(5-oxohexyl)theobromine

Country Status (1)

Country Link
JP (1) JPS5461193A (en)

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