JPS5492990A - Preparation of 1-(5-oxo-hexyl) theobromine - Google Patents

Preparation of 1-(5-oxo-hexyl) theobromine

Info

Publication number
JPS5492990A
JPS5492990A JP15748277A JP15748277A JPS5492990A JP S5492990 A JPS5492990 A JP S5492990A JP 15748277 A JP15748277 A JP 15748277A JP 15748277 A JP15748277 A JP 15748277A JP S5492990 A JPS5492990 A JP S5492990A
Authority
JP
Japan
Prior art keywords
compound
theobromine
formula
acetone
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15748277A
Other languages
Japanese (ja)
Other versions
JPS5840958B2 (en
Inventor
Yukinari Kobayashi
Hirokiyo Ichinomiya
Takanori Sone
Mikio Wakabayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Industry Co Ltd filed Critical Asahi Chemical Industry Co Ltd
Priority to JP52157482A priority Critical patent/JPS5840958B2/en
Publication of JPS5492990A publication Critical patent/JPS5492990A/en
Publication of JPS5840958B2 publication Critical patent/JPS5840958B2/en
Expired legal-status Critical Current

Links

Abstract

PURPOSE: To obtain the title compound which is a vasodilator and hematocytolysis enhancer of low toxicity in high purity and yield, by reacting a theobromine derivative with acetone in the presence of a base at high temperature and pressure, without forming by-products.
CONSTITUTION: A compound of formula I: (X is halogen) is suspended in a large excess of acetone, and an alkali (earth) metal compound is added to make the suspension basic. The reaction is carried out in an autoclave at high temperature, e.g. 120W170°C, and pressure to give a compound of formula II. An aprotic polar solvent, e.g. DMF, may be used as a solvent. The compound of formula I can be readily obtained by reacting theobromine with a 1,3-dihalopropane.
COPYRIGHT: (C)1979,JPO&Japio
JP52157482A 1977-12-28 1977-12-28 Production method of 1↓-(5↓-oxohexyl)theobromine Expired JPS5840958B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP52157482A JPS5840958B2 (en) 1977-12-28 1977-12-28 Production method of 1↓-(5↓-oxohexyl)theobromine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP52157482A JPS5840958B2 (en) 1977-12-28 1977-12-28 Production method of 1↓-(5↓-oxohexyl)theobromine

Publications (2)

Publication Number Publication Date
JPS5492990A true JPS5492990A (en) 1979-07-23
JPS5840958B2 JPS5840958B2 (en) 1983-09-08

Family

ID=15650636

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52157482A Expired JPS5840958B2 (en) 1977-12-28 1977-12-28 Production method of 1↓-(5↓-oxohexyl)theobromine

Country Status (1)

Country Link
JP (1) JPS5840958B2 (en)

Also Published As

Publication number Publication date
JPS5840958B2 (en) 1983-09-08

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