JPS5492990A - Preparation of 1-(5-oxo-hexyl) theobromine - Google Patents
Preparation of 1-(5-oxo-hexyl) theobromineInfo
- Publication number
- JPS5492990A JPS5492990A JP15748277A JP15748277A JPS5492990A JP S5492990 A JPS5492990 A JP S5492990A JP 15748277 A JP15748277 A JP 15748277A JP 15748277 A JP15748277 A JP 15748277A JP S5492990 A JPS5492990 A JP S5492990A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- theobromine
- formula
- acetone
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To obtain the title compound which is a vasodilator and hematocytolysis enhancer of low toxicity in high purity and yield, by reacting a theobromine derivative with acetone in the presence of a base at high temperature and pressure, without forming by-products.
CONSTITUTION: A compound of formula I: (X is halogen) is suspended in a large excess of acetone, and an alkali (earth) metal compound is added to make the suspension basic. The reaction is carried out in an autoclave at high temperature, e.g. 120W170°C, and pressure to give a compound of formula II. An aprotic polar solvent, e.g. DMF, may be used as a solvent. The compound of formula I can be readily obtained by reacting theobromine with a 1,3-dihalopropane.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP52157482A JPS5840958B2 (en) | 1977-12-28 | 1977-12-28 | Production method of 1↓-(5↓-oxohexyl)theobromine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP52157482A JPS5840958B2 (en) | 1977-12-28 | 1977-12-28 | Production method of 1↓-(5↓-oxohexyl)theobromine |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5492990A true JPS5492990A (en) | 1979-07-23 |
JPS5840958B2 JPS5840958B2 (en) | 1983-09-08 |
Family
ID=15650636
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52157482A Expired JPS5840958B2 (en) | 1977-12-28 | 1977-12-28 | Production method of 1↓-(5↓-oxohexyl)theobromine |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5840958B2 (en) |
-
1977
- 1977-12-28 JP JP52157482A patent/JPS5840958B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
JPS5840958B2 (en) | 1983-09-08 |
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