JPS56152461A - Preparation of indole derivative - Google Patents

Preparation of indole derivative

Info

Publication number
JPS56152461A
JPS56152461A JP5624480A JP5624480A JPS56152461A JP S56152461 A JPS56152461 A JP S56152461A JP 5624480 A JP5624480 A JP 5624480A JP 5624480 A JP5624480 A JP 5624480A JP S56152461 A JPS56152461 A JP S56152461A
Authority
JP
Japan
Prior art keywords
indole
formula
yloxymethyl
isopropylamine
reacted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5624480A
Other languages
Japanese (ja)
Inventor
Katsuo Shinozaki
Saburo Sugai
Tokuji Okazaki
Ichigaku Nagayama
Mitsuya Akaboshi
Shiro Ikegami
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
OTA SEIYAKU KK
Original Assignee
OTA SEIYAKU KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by OTA SEIYAKU KK filed Critical OTA SEIYAKU KK
Priority to JP5624480A priority Critical patent/JPS56152461A/en
Publication of JPS56152461A publication Critical patent/JPS56152461A/en
Pending legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

PURPOSE: To obtain the titled compound useful as a drug for remedying coronary occlusion, arrhythmia, etc. in high yield, by reacting 4-(indole-4-yloxymethyl)ethylenesulfide, a novel compound, with isopropylamine.
CONSTITUTION: 4-(2,3-Dihydroxypropoxy) indole shown by the formula I is reacted with a dialkylsulfite compound shown by the formula (RO)2SO (R is lower alkyl) in the presence of an acid or basic catalyst to give 4-(indole-4-yloxymethyl)ethylenesulfite shown by the formula I of a novel compound, a mixture of diastereomers, which is reacted with isopropylamine in a solvent, e.g., dimethylformamide, etc., and, if necessary, in a sealed tube, at room temperature to 100°C, to give 1-(indole- 4-yloxy)-3-isopropylamino-2-propanol shown by the formula III having β-acceptor inhibiting actions.
COPYRIGHT: (C)1981,JPO&Japio
JP5624480A 1980-04-30 1980-04-30 Preparation of indole derivative Pending JPS56152461A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5624480A JPS56152461A (en) 1980-04-30 1980-04-30 Preparation of indole derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5624480A JPS56152461A (en) 1980-04-30 1980-04-30 Preparation of indole derivative

Publications (1)

Publication Number Publication Date
JPS56152461A true JPS56152461A (en) 1981-11-26

Family

ID=13021671

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5624480A Pending JPS56152461A (en) 1980-04-30 1980-04-30 Preparation of indole derivative

Country Status (1)

Country Link
JP (1) JPS56152461A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58159446A (en) * 1981-12-17 1983-09-21 エ−ビ−　ヘツスル Manufacture of methoprorol

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58159446A (en) * 1981-12-17 1983-09-21 エ−ビ−　ヘツスル Manufacture of methoprorol

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