JPS5793971A - Preparation of piperazine derivative - Google Patents
Preparation of piperazine derivativeInfo
- Publication number
- JPS5793971A JPS5793971A JP56116540A JP11654081A JPS5793971A JP S5793971 A JPS5793971 A JP S5793971A JP 56116540 A JP56116540 A JP 56116540A JP 11654081 A JP11654081 A JP 11654081A JP S5793971 A JPS5793971 A JP S5793971A
- Authority
- JP
- Japan
- Prior art keywords
- cinnamyl
- preparation
- piperazine derivative
- coronary
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:The N-substituted trialkxoybenzylpiperazine derivative of formulaI(R is CH3 or C2H5; Z is cinnamyl).
EXAMPLE: N-Cinnamyl-N'-2,3,4-trimethoxybenzylpiperazine.
USE: Remedy for iscemic cardiopathy. It has various pharmacological activities to coronary circulatory system, e.g. cardiac motion suppressing action, coronary vessel dilating action, etc.
PROCESS: The compound of formulaIcan be prepared in high yield, by reacting N-trialkoxybenzylpiperazine of formula II with a cinnamyl halide in an inert solvent, if necessary in the presence of a proper acid acceptor, at room temp. W100°C for 0.5W6hr.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56116540A JPS5793971A (en) | 1981-07-24 | 1981-07-24 | Preparation of piperazine derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56116540A JPS5793971A (en) | 1981-07-24 | 1981-07-24 | Preparation of piperazine derivative |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2744277A Division JPS53112886A (en) | 1976-04-09 | 1977-03-12 | Production of n-substituted trialkoxybenzylpiperazine derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5793971A true JPS5793971A (en) | 1982-06-11 |
Family
ID=14689641
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56116540A Pending JPS5793971A (en) | 1981-07-24 | 1981-07-24 | Preparation of piperazine derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5793971A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0344577A2 (en) * | 1988-06-01 | 1989-12-06 | Eisai Co., Ltd. | Butenoic or propenoic acid derivatives |
-
1981
- 1981-07-24 JP JP56116540A patent/JPS5793971A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0344577A2 (en) * | 1988-06-01 | 1989-12-06 | Eisai Co., Ltd. | Butenoic or propenoic acid derivatives |
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