JPS5793971A - Preparation of piperazine derivative - Google Patents

Preparation of piperazine derivative

Info

Publication number
JPS5793971A
JPS5793971A JP56116540A JP11654081A JPS5793971A JP S5793971 A JPS5793971 A JP S5793971A JP 56116540 A JP56116540 A JP 56116540A JP 11654081 A JP11654081 A JP 11654081A JP S5793971 A JPS5793971 A JP S5793971A
Authority
JP
Japan
Prior art keywords
cinnamyl
preparation
piperazine derivative
coronary
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP56116540A
Other languages
Japanese (ja)
Inventor
Hiroshi Murai
Yoshiaki Aoyanagi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shinyaku Co Ltd
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Priority to JP56116540A priority Critical patent/JPS5793971A/en
Publication of JPS5793971A publication Critical patent/JPS5793971A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:The N-substituted trialkxoybenzylpiperazine derivative of formulaI(R is CH3 or C2H5; Z is cinnamyl).
EXAMPLE: N-Cinnamyl-N'-2,3,4-trimethoxybenzylpiperazine.
USE: Remedy for iscemic cardiopathy. It has various pharmacological activities to coronary circulatory system, e.g. cardiac motion suppressing action, coronary vessel dilating action, etc.
PROCESS: The compound of formulaIcan be prepared in high yield, by reacting N-trialkoxybenzylpiperazine of formula II with a cinnamyl halide in an inert solvent, if necessary in the presence of a proper acid acceptor, at room temp. W100°C for 0.5W6hr.
COPYRIGHT: (C)1982,JPO&Japio
JP56116540A 1981-07-24 1981-07-24 Preparation of piperazine derivative Pending JPS5793971A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56116540A JPS5793971A (en) 1981-07-24 1981-07-24 Preparation of piperazine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56116540A JPS5793971A (en) 1981-07-24 1981-07-24 Preparation of piperazine derivative

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2744277A Division JPS53112886A (en) 1976-04-09 1977-03-12 Production of n-substituted trialkoxybenzylpiperazine derivative

Publications (1)

Publication Number Publication Date
JPS5793971A true JPS5793971A (en) 1982-06-11

Family

ID=14689641

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56116540A Pending JPS5793971A (en) 1981-07-24 1981-07-24 Preparation of piperazine derivative

Country Status (1)

Country Link
JP (1) JPS5793971A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0344577A2 (en) * 1988-06-01 1989-12-06 Eisai Co., Ltd. Butenoic or propenoic acid derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0344577A2 (en) * 1988-06-01 1989-12-06 Eisai Co., Ltd. Butenoic or propenoic acid derivatives

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