JPS5793975A - Preparation of piperazine derivative - Google Patents
Preparation of piperazine derivativeInfo
- Publication number
- JPS5793975A JPS5793975A JP56116538A JP11653881A JPS5793975A JP S5793975 A JPS5793975 A JP S5793975A JP 56116538 A JP56116538 A JP 56116538A JP 11653881 A JP11653881 A JP 11653881A JP S5793975 A JPS5793975 A JP S5793975A
- Authority
- JP
- Japan
- Prior art keywords
- morpholinoethyl
- trialkoxybenzylpiperazine
- preparation
- piperazine derivative
- coronary
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:The N-substituted trialkoxybenzylpiperazine derivative of formulaI(R is CH3 or C2H5; Z is morpholinoethyl).
EXAMPLE: N-Morpholinoethyl-N'-2,3,4-trimethoxybenzylpiperazine.
USE: Remedy for iscemic cardiopathy. It has various pharmacological activities to coronary circulatory system, such as coronary vessel dilating action, cardiac motion suppressing action, etc.
PROCESS: The compound of formulaIcan be prepared in high yield, by reacting the N-trialkoxybenzylpiperazine of formula II with a morpholinoethyl halide in an inert solvent such as ethanol, at room temp. W100°C for 0.5W6hr, if necessary in the presence of a proper acid acceptor.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56116538A JPS5793975A (en) | 1981-07-24 | 1981-07-24 | Preparation of piperazine derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56116538A JPS5793975A (en) | 1981-07-24 | 1981-07-24 | Preparation of piperazine derivative |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2744277A Division JPS53112886A (en) | 1976-04-09 | 1977-03-12 | Production of n-substituted trialkoxybenzylpiperazine derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5793975A true JPS5793975A (en) | 1982-06-11 |
Family
ID=14689596
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56116538A Pending JPS5793975A (en) | 1981-07-24 | 1981-07-24 | Preparation of piperazine derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5793975A (en) |
-
1981
- 1981-07-24 JP JP56116538A patent/JPS5793975A/en active Pending
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