JPS5793975A - Preparation of piperazine derivative - Google Patents

Preparation of piperazine derivative

Info

Publication number
JPS5793975A
JPS5793975A JP56116538A JP11653881A JPS5793975A JP S5793975 A JPS5793975 A JP S5793975A JP 56116538 A JP56116538 A JP 56116538A JP 11653881 A JP11653881 A JP 11653881A JP S5793975 A JPS5793975 A JP S5793975A
Authority
JP
Japan
Prior art keywords
morpholinoethyl
trialkoxybenzylpiperazine
preparation
piperazine derivative
coronary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP56116538A
Other languages
Japanese (ja)
Inventor
Hiroshi Murai
Yoshiaki Aoyanagi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shinyaku Co Ltd
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Priority to JP56116538A priority Critical patent/JPS5793975A/en
Publication of JPS5793975A publication Critical patent/JPS5793975A/en
Pending legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:The N-substituted trialkoxybenzylpiperazine derivative of formulaI(R is CH3 or C2H5; Z is morpholinoethyl).
EXAMPLE: N-Morpholinoethyl-N'-2,3,4-trimethoxybenzylpiperazine.
USE: Remedy for iscemic cardiopathy. It has various pharmacological activities to coronary circulatory system, such as coronary vessel dilating action, cardiac motion suppressing action, etc.
PROCESS: The compound of formulaIcan be prepared in high yield, by reacting the N-trialkoxybenzylpiperazine of formula II with a morpholinoethyl halide in an inert solvent such as ethanol, at room temp. W100°C for 0.5W6hr, if necessary in the presence of a proper acid acceptor.
COPYRIGHT: (C)1982,JPO&Japio
JP56116538A 1981-07-24 1981-07-24 Preparation of piperazine derivative Pending JPS5793975A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56116538A JPS5793975A (en) 1981-07-24 1981-07-24 Preparation of piperazine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56116538A JPS5793975A (en) 1981-07-24 1981-07-24 Preparation of piperazine derivative

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2744277A Division JPS53112886A (en) 1976-04-09 1977-03-12 Production of n-substituted trialkoxybenzylpiperazine derivative

Publications (1)

Publication Number Publication Date
JPS5793975A true JPS5793975A (en) 1982-06-11

Family

ID=14689596

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56116538A Pending JPS5793975A (en) 1981-07-24 1981-07-24 Preparation of piperazine derivative

Country Status (1)

Country Link
JP (1) JPS5793975A (en)

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