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Nippon Shinyaku Co Ltd
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Nippon Shinyaku Co Ltd
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Application filed by Nippon Shinyaku Co LtdfiledCriticalNippon Shinyaku Co Ltd
Priority to JP56116542ApriorityCriticalpatent/JPS57140777A/en
Publication of JPS57140777ApublicationCriticalpatent/JPS57140777A/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
NEW MATERIAL:The N-substituted trialkoxybenzylpiperazine derivative of formulaI(R is methyl or ethyl; Z is group of formula II; n is 2W8).
USE: It has pharmacological activities to the cornary circulation system, e.g. coronary vessel dilating action, cardiac motion suppressing action, etc., and is useful as a medicine such as remedy for ischemic cardiopathy. Dose: preferably about 10W500mg daily for oral administration and about 1W50mg daily for intravenous injection to human body.
PROCESS: The compound of formulaIcan be prepared by reacting the compound of formula III with the compound of formula IV (X is halogen) in the presence of a proper acid scavenger such as alkali metal carbonate, caustic alkali, etc. in an inert solvent such as alcohol, dioxane, etc.
COPYRIGHT: (C)1982,JPO&Japio
JP56116542A1981-07-241981-07-24Preparation of piperazine derivative
PendingJPS57140777A
(en)
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