JPS55111470A - Geldanamycin derivative, its preparation, antitumor drug comprising it as active ingredient - Google Patents

Geldanamycin derivative, its preparation, antitumor drug comprising it as active ingredient

Info

Publication number
JPS55111470A
JPS55111470A JP1721979A JP1721979A JPS55111470A JP S55111470 A JPS55111470 A JP S55111470A JP 1721979 A JP1721979 A JP 1721979A JP 1721979 A JP1721979 A JP 1721979A JP S55111470 A JPS55111470 A JP S55111470A
Authority
JP
Japan
Prior art keywords
formula
geldanamycin
preparation
active ingredient
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1721979A
Other languages
Japanese (ja)
Other versions
JPS6312065B2 (en
Inventor
Kazuya Sasaki
Yukio Inoue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kaken Pharmaceutical Co Ltd
Original Assignee
Kaken Pharmaceutical Co Ltd
Kaken Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaken Pharmaceutical Co Ltd, Kaken Chemical Co Ltd filed Critical Kaken Pharmaceutical Co Ltd
Priority to JP1721979A priority Critical patent/JPS55111470A/en
Priority to US06/109,314 priority patent/US4261989A/en
Priority to AU54430/80A priority patent/AU532333B2/en
Priority to GB8001321A priority patent/GB2042523B/en
Priority to FR8002589A priority patent/FR2449084A1/en
Priority to NL8000857A priority patent/NL8000857A/en
Priority to CA345,489A priority patent/CA1113935A/en
Priority to DE19803006097 priority patent/DE3006097A1/en
Priority to IT20017/80A priority patent/IT1147315B/en
Publication of JPS55111470A publication Critical patent/JPS55111470A/en
Publication of JPS6312065B2 publication Critical patent/JPS6312065B2/ja
Granted legal-status Critical Current

Links

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  • Other In-Based Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A geldamycin derivative shown by formula I (R1 is methoxy or di lower alkyl amino; R2 is di lower alkyl amino).
EXAMPLE: 17-Dimethoxy-17,19-bisdimethylamino-geldanamycin.
USE: A synthetic intermediate for an antitumor agent, a drug for a veterinarian, or other derivative. a daily dose for an adult is 0.5W80mg/kg in the case of nonoral administration and 1W100mg/kg in the case of oral administration.
PROCESS: A geldanamycin shown by the formula II is reacted with a di lower alkylamine, e.g., dimethylamine, preferably in an organic solvent, e.g., a mixed solvent of chloroform and methanol at room temperature to give the desired compound shown by the formula I. The di lower alkylamine can also be used in the form of an aqueous solution.
COPYRIGHT: (C)1980,JPO&Japio
JP1721979A 1979-02-19 1979-02-19 Geldanamycin derivative, its preparation, antitumor drug comprising it as active ingredient Granted JPS55111470A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP1721979A JPS55111470A (en) 1979-02-19 1979-02-19 Geldanamycin derivative, its preparation, antitumor drug comprising it as active ingredient
US06/109,314 US4261989A (en) 1979-02-19 1980-01-03 Geldanamycin derivatives and antitumor drug
AU54430/80A AU532333B2 (en) 1979-02-19 1980-01-08 Geldanamycin derivatives
GB8001321A GB2042523B (en) 1979-02-19 1980-01-15 Geldanamycin derivatives and anti-tumor drug
FR8002589A FR2449084A1 (en) 1979-02-19 1980-02-06 NOVEL GELDANAMYCIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
NL8000857A NL8000857A (en) 1979-02-19 1980-02-12 MONEY ANAMYCIN DERIVATIVES, METHOD FOR PREPARING THE SAME AND USE AS A MEDICINAL PRODUCT.
CA345,489A CA1113935A (en) 1979-02-19 1980-02-13 Geldanamycin derivatives and antitumor drug
DE19803006097 DE3006097A1 (en) 1979-02-19 1980-02-19 MONEY AMININE DERIVATIVES AND ANTITUARY MEDICINES WITH THE SAME
IT20017/80A IT1147315B (en) 1979-02-19 1980-02-19 GELDANAMYCIN DERIVATIVES AND ANTI-CANCER DRUGS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1721979A JPS55111470A (en) 1979-02-19 1979-02-19 Geldanamycin derivative, its preparation, antitumor drug comprising it as active ingredient

Publications (2)

Publication Number Publication Date
JPS55111470A true JPS55111470A (en) 1980-08-28
JPS6312065B2 JPS6312065B2 (en) 1988-03-17

Family

ID=11937822

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1721979A Granted JPS55111470A (en) 1979-02-19 1979-02-19 Geldanamycin derivative, its preparation, antitumor drug comprising it as active ingredient

Country Status (1)

Country Link
JP (1) JPS55111470A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6872715B2 (en) 2001-08-06 2005-03-29 Kosan Biosciences, Inc. Benzoquinone ansamycins
US6890917B2 (en) 2001-03-30 2005-05-10 The United States Of America As Represented By The Department Of Health And Human Services Geldanamycin derivative and method of treating cancer using same
US7259156B2 (en) 2004-05-20 2007-08-21 Kosan Biosciences Incorporated Geldanamycin compounds and method of use

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0457021U (en) * 1990-09-10 1992-05-15

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6890917B2 (en) 2001-03-30 2005-05-10 The United States Of America As Represented By The Department Of Health And Human Services Geldanamycin derivative and method of treating cancer using same
US6872715B2 (en) 2001-08-06 2005-03-29 Kosan Biosciences, Inc. Benzoquinone ansamycins
US7405208B2 (en) 2001-08-06 2008-07-29 Kosan Biosciences, Inc. Benzoquinone ansamycins
US7259156B2 (en) 2004-05-20 2007-08-21 Kosan Biosciences Incorporated Geldanamycin compounds and method of use
US7378407B2 (en) 2004-05-20 2008-05-27 Kosan Biosciences Incorporated Geldanamycin compounds and method of use

Also Published As

Publication number Publication date
JPS6312065B2 (en) 1988-03-17

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