JPS54100385A - 5-fluorouracil derivative and its preparation - Google Patents
5-fluorouracil derivative and its preparationInfo
- Publication number
- JPS54100385A JPS54100385A JP614378A JP614378A JPS54100385A JP S54100385 A JPS54100385 A JP S54100385A JP 614378 A JP614378 A JP 614378A JP 614378 A JP614378 A JP 614378A JP S54100385 A JPS54100385 A JP S54100385A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- fluorouracil
- preparation
- reaction
- fluorouracil derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:5-Fluorouracil derivatives of formula I (R is lower alkyl).
EXAMPLE: 1-(2'-chloro-1'-ethoxy)ethyl-5-fluorouracil.
USE: Anticarcinostatic agent or starting material of 5-fluorouracil derivatives. It is better in fat-soluble properties and the improvement in absorbability on oral administration and toxicity reduction is expected.
PREPARATION: The reaction between 2,4-bistrimethylsilyloxy-5-fluoropyrimidine and 1,2-dischloroethyl ether of formula II is conducted in a dilute solution of an organic solvent as dichloromethane or dioxane, then the reaction mixture is concentrated, under reduced pressure. Further the trimethylsilyl groups are eliminated by adding water to prepare the compound of formula I. The reaction proceeds at low temperature when a Lewis acid is added as a catalyst.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP614378A JPS54100385A (en) | 1978-01-25 | 1978-01-25 | 5-fluorouracil derivative and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP614378A JPS54100385A (en) | 1978-01-25 | 1978-01-25 | 5-fluorouracil derivative and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS54100385A true JPS54100385A (en) | 1979-08-08 |
Family
ID=11630285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP614378A Pending JPS54100385A (en) | 1978-01-25 | 1978-01-25 | 5-fluorouracil derivative and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS54100385A (en) |
-
1978
- 1978-01-25 JP JP614378A patent/JPS54100385A/en active Pending
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