JPS5527124A - Novel estradiol compound, its preparation and anti-tumor agent containing the same - Google Patents
Novel estradiol compound, its preparation and anti-tumor agent containing the sameInfo
- Publication number
- JPS5527124A JPS5527124A JP9879878A JP9879878A JPS5527124A JP S5527124 A JPS5527124 A JP S5527124A JP 9879878 A JP9879878 A JP 9879878A JP 9879878 A JP9879878 A JP 9879878A JP S5527124 A JPS5527124 A JP S5527124A
- Authority
- JP
- Japan
- Prior art keywords
- tumor agent
- cancer
- estradiol
- preparation
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
NEW MATERIAL:An addition compound of formula composed of an estradiol derivative and 5-fluorouracil.
USE: An anti-tumor agent having selectivity to cancer cells having receptors, and low side effects. Especially effective to breast cancer, solenoma, prostatic cancer, nephritic cancer, thyroid cancer, etc.
PROCESS: The compound is prepared by reacting the 17-OH group of estradiol with a functional group-introducing agent (e.g. monobromoacetyl bromide), and reacting the resulted estradiol-17-monobromoacetate with 5-fluorouracil silver salt (anti- tumor agent) at 0W100°C for 2W74 hours.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9879878A JPS5810399B2 (en) | 1978-08-14 | 1978-08-14 | Novel estradiol conjugate, its production method and antitumor agent |
US06/062,819 US4260736A (en) | 1978-08-14 | 1979-08-01 | Steroid hormone-antitumor derivatives |
FR7920546A FR2433537A1 (en) | 1978-08-14 | 1979-08-10 | DERIVATIVES OF ANTI-TUMOR STEROID HORMONES AND THEIR PREPARATION METHOD |
DE2932606A DE2932606C2 (en) | 1978-08-14 | 1979-08-10 | Estradiol antitumor derivatives |
CA000333653A CA1120922A (en) | 1978-08-14 | 1979-08-13 | Steroid hormone antitumor derivatives |
CH740179A CH642976A5 (en) | 1978-08-14 | 1979-08-13 | METHOD FOR PRODUCING STEROIDHORMONE ANTITUM OR DERIVATIVES. |
IT25084/79A IT1196399B (en) | 1978-08-14 | 1979-08-13 | STEROID HORMONE-BASED ANTI-TUMOR DERIVATIVES |
GB7928321A GB2028336B (en) | 1978-08-14 | 1979-08-14 | Steroid hormone-antitumour drug conjugates |
NL7906178A NL190747C (en) | 1978-08-14 | 1979-08-14 | A method of preparing a drug having an anti-tumor effect and a method of preparing steroid derivatives suitable for use in the former method. |
ES483411A ES483411A1 (en) | 1978-08-14 | 1979-08-14 | A procedure for the production of an antitumoral derivative of steroid hormone. (Machine-translation by Google Translate, not legally binding) |
US06/212,117 US4360663A (en) | 1978-08-14 | 1980-12-02 | Steroid hormone-antitumor derivatives |
FR8101887A FR2476093A1 (en) | 1978-08-14 | 1981-01-30 | NOVEL 3-HYDROXY OR 3-ACYLOXY 1,3,5 (10) -ESTRATRIENE-17B-OXYCARBONYLMETHYL COMPOUNDS AND THEIR THERAPEUTIC APPLICATION |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9879878A JPS5810399B2 (en) | 1978-08-14 | 1978-08-14 | Novel estradiol conjugate, its production method and antitumor agent |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5527124A true JPS5527124A (en) | 1980-02-27 |
JPS5810399B2 JPS5810399B2 (en) | 1983-02-25 |
Family
ID=14229365
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9879878A Expired JPS5810399B2 (en) | 1978-08-14 | 1978-08-14 | Novel estradiol conjugate, its production method and antitumor agent |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5810399B2 (en) |
-
1978
- 1978-08-14 JP JP9879878A patent/JPS5810399B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
JPS5810399B2 (en) | 1983-02-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES484168A1 (en) | 9-Hydroxyalkyl-purines, processes for preparing them and therapeutical composition containing the 9-hydroxyalkyl-purines as active ingredients. | |
JPS57176982A (en) | Dioxolanylazetidinone compound, its preparation and use | |
JPS5527124A (en) | Novel estradiol compound, its preparation and anti-tumor agent containing the same | |
JPS5527123A (en) | Novel estradiol compound, its preparation and anti-tumor agent containing the same | |
JPS5527125A (en) | Novel estradiol compound, its preparation and anti-tumor agent containing the same | |
JPS5527121A (en) | Novel estradiol compound, its preparation and anti-tumor agent containing the same | |
JPS56154427A (en) | Novel 2-phenylpropyl ether derivative, its preparation and insecticide and miticide with low toxicity to fish containing the same | |
JPS52285A (en) | Preparation of n1 *22tetrahydrofuryl**55fluorouracil | |
JPS5742643A (en) | 6,10,14,18-tetramethyl-5,9,13,17-nonadecatetraene-2-ol | |
JPS5527122A (en) | Novel estradiol compound, its preparation and anti-tumor agent containing the same | |
JPS5618933A (en) | Dihydroxy aluminum salt of substituted acetic acid and its preparation | |
JPS56127378A (en) | 2-alkoxyindolizine derivative and its preparation | |
JPS5655365A (en) | Preparation of indole or indole derivative | |
JPS5524146A (en) | Novel estradiol derivative and its preparation | |
JPS55157574A (en) | 5-fluorouracyl derivative and its preparation | |
JPS56158786A (en) | Novel camptothecin derivative and its preparation | |
JPS54100385A (en) | 5-fluorouracil derivative and its preparation | |
JPS5772925A (en) | Liquid branched chain higher alphatic 1-ol and its preparation | |
JPS5625166A (en) | 5-fluorouracil derivative | |
JPS57142964A (en) | Sulfonium compound and its preparation | |
JPS56127763A (en) | Powder material for electroless niclel plating bath | |
JPS5587799A (en) | 1-beta-d-arabinofuranosyl-5-vinyluracil and its preparation | |
JPS56127376A (en) | Indolizine-2-one derivative and its preparation | |
JPS5746948A (en) | Production of beta- 1,2,2,-trifluoro-2-alkoxyethyl alanine derivative | |
JPS5557571A (en) | Novel 5-fluorouracil derivative |