JPS5527124A - Novel estradiol compound, its preparation and anti-tumor agent containing the same - Google Patents

Novel estradiol compound, its preparation and anti-tumor agent containing the same

Info

Publication number
JPS5527124A
JPS5527124A JP9879878A JP9879878A JPS5527124A JP S5527124 A JPS5527124 A JP S5527124A JP 9879878 A JP9879878 A JP 9879878A JP 9879878 A JP9879878 A JP 9879878A JP S5527124 A JPS5527124 A JP S5527124A
Authority
JP
Japan
Prior art keywords
tumor agent
cancer
estradiol
preparation
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP9879878A
Other languages
Japanese (ja)
Other versions
JPS5810399B2 (en
Inventor
Yoshiro Asano
Fumio Tamura
Hiromitsu Tanaka
Satoshi Enomoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kureha Corp
Original Assignee
Kureha Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kureha Corp filed Critical Kureha Corp
Priority to JP9879878A priority Critical patent/JPS5810399B2/en
Priority to US06/062,819 priority patent/US4260736A/en
Priority to FR7920546A priority patent/FR2433537A1/en
Priority to DE2932606A priority patent/DE2932606C2/en
Priority to CA000333653A priority patent/CA1120922A/en
Priority to CH740179A priority patent/CH642976A5/en
Priority to IT25084/79A priority patent/IT1196399B/en
Priority to GB7928321A priority patent/GB2028336B/en
Priority to NL7906178A priority patent/NL190747C/en
Priority to ES483411A priority patent/ES483411A1/en
Publication of JPS5527124A publication Critical patent/JPS5527124A/en
Priority to US06/212,117 priority patent/US4360663A/en
Priority to FR8101887A priority patent/FR2476093A1/en
Publication of JPS5810399B2 publication Critical patent/JPS5810399B2/en
Expired legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

NEW MATERIAL:An addition compound of formula composed of an estradiol derivative and 5-fluorouracil.
USE: An anti-tumor agent having selectivity to cancer cells having receptors, and low side effects. Especially effective to breast cancer, solenoma, prostatic cancer, nephritic cancer, thyroid cancer, etc.
PROCESS: The compound is prepared by reacting the 17-OH group of estradiol with a functional group-introducing agent (e.g. monobromoacetyl bromide), and reacting the resulted estradiol-17-monobromoacetate with 5-fluorouracil silver salt (anti- tumor agent) at 0W100°C for 2W74 hours.
COPYRIGHT: (C)1980,JPO&Japio
JP9879878A 1978-08-14 1978-08-14 Novel estradiol conjugate, its production method and antitumor agent Expired JPS5810399B2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
JP9879878A JPS5810399B2 (en) 1978-08-14 1978-08-14 Novel estradiol conjugate, its production method and antitumor agent
US06/062,819 US4260736A (en) 1978-08-14 1979-08-01 Steroid hormone-antitumor derivatives
FR7920546A FR2433537A1 (en) 1978-08-14 1979-08-10 DERIVATIVES OF ANTI-TUMOR STEROID HORMONES AND THEIR PREPARATION METHOD
DE2932606A DE2932606C2 (en) 1978-08-14 1979-08-10 Estradiol antitumor derivatives
CA000333653A CA1120922A (en) 1978-08-14 1979-08-13 Steroid hormone antitumor derivatives
CH740179A CH642976A5 (en) 1978-08-14 1979-08-13 METHOD FOR PRODUCING STEROIDHORMONE ANTITUM OR DERIVATIVES.
IT25084/79A IT1196399B (en) 1978-08-14 1979-08-13 STEROID HORMONE-BASED ANTI-TUMOR DERIVATIVES
GB7928321A GB2028336B (en) 1978-08-14 1979-08-14 Steroid hormone-antitumour drug conjugates
NL7906178A NL190747C (en) 1978-08-14 1979-08-14 A method of preparing a drug having an anti-tumor effect and a method of preparing steroid derivatives suitable for use in the former method.
ES483411A ES483411A1 (en) 1978-08-14 1979-08-14 A procedure for the production of an antitumoral derivative of steroid hormone. (Machine-translation by Google Translate, not legally binding)
US06/212,117 US4360663A (en) 1978-08-14 1980-12-02 Steroid hormone-antitumor derivatives
FR8101887A FR2476093A1 (en) 1978-08-14 1981-01-30 NOVEL 3-HYDROXY OR 3-ACYLOXY 1,3,5 (10) -ESTRATRIENE-17B-OXYCARBONYLMETHYL COMPOUNDS AND THEIR THERAPEUTIC APPLICATION

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9879878A JPS5810399B2 (en) 1978-08-14 1978-08-14 Novel estradiol conjugate, its production method and antitumor agent

Publications (2)

Publication Number Publication Date
JPS5527124A true JPS5527124A (en) 1980-02-27
JPS5810399B2 JPS5810399B2 (en) 1983-02-25

Family

ID=14229365

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9879878A Expired JPS5810399B2 (en) 1978-08-14 1978-08-14 Novel estradiol conjugate, its production method and antitumor agent

Country Status (1)

Country Link
JP (1) JPS5810399B2 (en)

Also Published As

Publication number Publication date
JPS5810399B2 (en) 1983-02-25

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