JPS5527125A - Novel estradiol compound, its preparation and anti-tumor agent containing the same - Google Patents
Novel estradiol compound, its preparation and anti-tumor agent containing the sameInfo
- Publication number
- JPS5527125A JPS5527125A JP9879978A JP9879978A JPS5527125A JP S5527125 A JPS5527125 A JP S5527125A JP 9879978 A JP9879978 A JP 9879978A JP 9879978 A JP9879978 A JP 9879978A JP S5527125 A JPS5527125 A JP S5527125A
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- estradiol
- tumor agent
- preparation
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
NEW MATERIAL:An addition compound of the formula derived from an estradiol derivative and daunorubicin.
USE: An anti-tumer agent having selectivity to cancer cells having receptors, and low side effects. Especially effective to breast cancer, solenoma, prostatic cancer, nephritic cancer, thyroid cancer, etc.
PROCESS: The compound is prepared by reacting the 17-OH group of estradiol with a functional group-introducing agent (e.g. monobromoacetyl bromide) and reacting the resulted estradiol-17-monobromoacertate with daunorubicin hydrochloride (an anti-tumor agent) at 0W100°C for 2W74 hours.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9879978A JPS5810395B2 (en) | 1978-08-14 | 1978-08-14 | Novel estradiol conjugate, its production method and antitumor agent |
US06/062,819 US4260736A (en) | 1978-08-14 | 1979-08-01 | Steroid hormone-antitumor derivatives |
FR7920546A FR2433537A1 (en) | 1978-08-14 | 1979-08-10 | DERIVATIVES OF ANTI-TUMOR STEROID HORMONES AND THEIR PREPARATION METHOD |
DE2932606A DE2932606C2 (en) | 1978-08-14 | 1979-08-10 | Estradiol antitumor derivatives |
CA000333653A CA1120922A (en) | 1978-08-14 | 1979-08-13 | Steroid hormone antitumor derivatives |
CH740179A CH642976A5 (en) | 1978-08-14 | 1979-08-13 | METHOD FOR PRODUCING STEROIDHORMONE ANTITUM OR DERIVATIVES. |
IT25084/79A IT1196399B (en) | 1978-08-14 | 1979-08-13 | STEROID HORMONE-BASED ANTI-TUMOR DERIVATIVES |
GB7928321A GB2028336B (en) | 1978-08-14 | 1979-08-14 | Steroid hormone-antitumour drug conjugates |
NL7906178A NL190747C (en) | 1978-08-14 | 1979-08-14 | A method of preparing a drug having an anti-tumor effect and a method of preparing steroid derivatives suitable for use in the former method. |
ES483411A ES483411A1 (en) | 1978-08-14 | 1979-08-14 | A procedure for the production of an antitumoral derivative of steroid hormone. (Machine-translation by Google Translate, not legally binding) |
US06/212,117 US4360663A (en) | 1978-08-14 | 1980-12-02 | Steroid hormone-antitumor derivatives |
FR8101887A FR2476093A1 (en) | 1978-08-14 | 1981-01-30 | NOVEL 3-HYDROXY OR 3-ACYLOXY 1,3,5 (10) -ESTRATRIENE-17B-OXYCARBONYLMETHYL COMPOUNDS AND THEIR THERAPEUTIC APPLICATION |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9879978A JPS5810395B2 (en) | 1978-08-14 | 1978-08-14 | Novel estradiol conjugate, its production method and antitumor agent |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5527125A true JPS5527125A (en) | 1980-02-27 |
JPS5810395B2 JPS5810395B2 (en) | 1983-02-25 |
Family
ID=14229390
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9879978A Expired JPS5810395B2 (en) | 1978-08-14 | 1978-08-14 | Novel estradiol conjugate, its production method and antitumor agent |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5810395B2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH065678U (en) * | 1992-01-06 | 1994-01-25 | 株式会社フタバ工業 | Pachinko ball polishing machine |
-
1978
- 1978-08-14 JP JP9879978A patent/JPS5810395B2/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH065678U (en) * | 1992-01-06 | 1994-01-25 | 株式会社フタバ工業 | Pachinko ball polishing machine |
Also Published As
Publication number | Publication date |
---|---|
JPS5810395B2 (en) | 1983-02-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE2964059D1 (en) | 9-hydroxyalkyl-purines, processes for preparing them and therapeutical composition containing the 9-hydroxyalkyl-purines as active ingredients | |
JPS5432460A (en) | Cycloalkylidenemethylphenylacetic acid derivative and their preparation | |
JPS5576829A (en) | Beta,gamma-dihydropolyprenyl alcohol and hypotensive agent made from it | |
JPS57176982A (en) | Dioxolanylazetidinone compound, its preparation and use | |
JPS5527125A (en) | Novel estradiol compound, its preparation and anti-tumor agent containing the same | |
JPS5527123A (en) | Novel estradiol compound, its preparation and anti-tumor agent containing the same | |
JPS5527124A (en) | Novel estradiol compound, its preparation and anti-tumor agent containing the same | |
JPS57163393A (en) | Novel anthracyclin derivative and its preparation | |
JPS5527121A (en) | Novel estradiol compound, its preparation and anti-tumor agent containing the same | |
JPS5410399A (en) | Preparation of polyalkylene glycol derivative | |
JPS5716852A (en) | Nitrile derivative, its preparation, and fibrosis suppressing agent containing the same | |
JPS5655383A (en) | Amizine derivative and its preparation | |
JPS5524146A (en) | Novel estradiol derivative and its preparation | |
JPS5742643A (en) | 6,10,14,18-tetramethyl-5,9,13,17-nonadecatetraene-2-ol | |
JPS56127378A (en) | 2-alkoxyindolizine derivative and its preparation | |
JPS5527122A (en) | Novel estradiol compound, its preparation and anti-tumor agent containing the same | |
JPS5589299A (en) | Novel estradiol derivative, its preparation, and antitumor agent | |
JPS5663991A (en) | Glucosamine derivative and its preparation | |
JPS5772997A (en) | Novel oligomannoside and its preparation | |
JPS5655365A (en) | Preparation of indole or indole derivative | |
JPS5772925A (en) | Liquid branched chain higher alphatic 1-ol and its preparation | |
JPS54100385A (en) | 5-fluorouracil derivative and its preparation | |
JPS5634695A (en) | Novel anthracycline derivative and its preparation | |
JPS5735588A (en) | Carbostyrile derivative | |
JPS5579400A (en) | Novel estradiol derivative, its preparation, and antitumor agent |