JPS5527125A - Novel estradiol compound, its preparation and anti-tumor agent containing the same - Google Patents

Novel estradiol compound, its preparation and anti-tumor agent containing the same

Info

Publication number
JPS5527125A
JPS5527125A JP9879978A JP9879978A JPS5527125A JP S5527125 A JPS5527125 A JP S5527125A JP 9879978 A JP9879978 A JP 9879978A JP 9879978 A JP9879978 A JP 9879978A JP S5527125 A JPS5527125 A JP S5527125A
Authority
JP
Japan
Prior art keywords
cancer
estradiol
tumor agent
preparation
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP9879978A
Other languages
Japanese (ja)
Other versions
JPS5810395B2 (en
Inventor
Yoshiro Asano
Fumio Tamura
Hiromitsu Tanaka
Satoshi Enomoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kureha Corp
Original Assignee
Kureha Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kureha Corp filed Critical Kureha Corp
Priority to JP9879978A priority Critical patent/JPS5810395B2/en
Priority to US06/062,819 priority patent/US4260736A/en
Priority to FR7920546A priority patent/FR2433537A1/en
Priority to DE2932606A priority patent/DE2932606C2/en
Priority to CA000333653A priority patent/CA1120922A/en
Priority to CH740179A priority patent/CH642976A5/en
Priority to IT25084/79A priority patent/IT1196399B/en
Priority to GB7928321A priority patent/GB2028336B/en
Priority to NL7906178A priority patent/NL190747C/en
Priority to ES483411A priority patent/ES483411A1/en
Publication of JPS5527125A publication Critical patent/JPS5527125A/en
Priority to US06/212,117 priority patent/US4360663A/en
Priority to FR8101887A priority patent/FR2476093A1/en
Publication of JPS5810395B2 publication Critical patent/JPS5810395B2/en
Expired legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

NEW MATERIAL:An addition compound of the formula derived from an estradiol derivative and daunorubicin.
USE: An anti-tumer agent having selectivity to cancer cells having receptors, and low side effects. Especially effective to breast cancer, solenoma, prostatic cancer, nephritic cancer, thyroid cancer, etc.
PROCESS: The compound is prepared by reacting the 17-OH group of estradiol with a functional group-introducing agent (e.g. monobromoacetyl bromide) and reacting the resulted estradiol-17-monobromoacertate with daunorubicin hydrochloride (an anti-tumor agent) at 0W100°C for 2W74 hours.
COPYRIGHT: (C)1980,JPO&Japio
JP9879978A 1978-08-14 1978-08-14 Novel estradiol conjugate, its production method and antitumor agent Expired JPS5810395B2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
JP9879978A JPS5810395B2 (en) 1978-08-14 1978-08-14 Novel estradiol conjugate, its production method and antitumor agent
US06/062,819 US4260736A (en) 1978-08-14 1979-08-01 Steroid hormone-antitumor derivatives
FR7920546A FR2433537A1 (en) 1978-08-14 1979-08-10 DERIVATIVES OF ANTI-TUMOR STEROID HORMONES AND THEIR PREPARATION METHOD
DE2932606A DE2932606C2 (en) 1978-08-14 1979-08-10 Estradiol antitumor derivatives
CA000333653A CA1120922A (en) 1978-08-14 1979-08-13 Steroid hormone antitumor derivatives
CH740179A CH642976A5 (en) 1978-08-14 1979-08-13 METHOD FOR PRODUCING STEROIDHORMONE ANTITUM OR DERIVATIVES.
IT25084/79A IT1196399B (en) 1978-08-14 1979-08-13 STEROID HORMONE-BASED ANTI-TUMOR DERIVATIVES
GB7928321A GB2028336B (en) 1978-08-14 1979-08-14 Steroid hormone-antitumour drug conjugates
NL7906178A NL190747C (en) 1978-08-14 1979-08-14 A method of preparing a drug having an anti-tumor effect and a method of preparing steroid derivatives suitable for use in the former method.
ES483411A ES483411A1 (en) 1978-08-14 1979-08-14 A procedure for the production of an antitumoral derivative of steroid hormone. (Machine-translation by Google Translate, not legally binding)
US06/212,117 US4360663A (en) 1978-08-14 1980-12-02 Steroid hormone-antitumor derivatives
FR8101887A FR2476093A1 (en) 1978-08-14 1981-01-30 NOVEL 3-HYDROXY OR 3-ACYLOXY 1,3,5 (10) -ESTRATRIENE-17B-OXYCARBONYLMETHYL COMPOUNDS AND THEIR THERAPEUTIC APPLICATION

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9879978A JPS5810395B2 (en) 1978-08-14 1978-08-14 Novel estradiol conjugate, its production method and antitumor agent

Publications (2)

Publication Number Publication Date
JPS5527125A true JPS5527125A (en) 1980-02-27
JPS5810395B2 JPS5810395B2 (en) 1983-02-25

Family

ID=14229390

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9879978A Expired JPS5810395B2 (en) 1978-08-14 1978-08-14 Novel estradiol conjugate, its production method and antitumor agent

Country Status (1)

Country Link
JP (1) JPS5810395B2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH065678U (en) * 1992-01-06 1994-01-25 株式会社フタバ工業 Pachinko ball polishing machine

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH065678U (en) * 1992-01-06 1994-01-25 株式会社フタバ工業 Pachinko ball polishing machine

Also Published As

Publication number Publication date
JPS5810395B2 (en) 1983-02-25

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