JPS574986A - Preparation of oxazolidine derivative - Google Patents
Preparation of oxazolidine derivativeInfo
- Publication number
- JPS574986A JPS574986A JP7912680A JP7912680A JPS574986A JP S574986 A JPS574986 A JP S574986A JP 7912680 A JP7912680 A JP 7912680A JP 7912680 A JP7912680 A JP 7912680A JP S574986 A JPS574986 A JP S574986A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- alkyl
- derivative
- useful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: To obtain the titled compound in high yield useful as an intermediate for synthesizing drugs, by reacting a methylnitrophenol derivative of oxazolidine with a substituted formamide derivative, followed by reduction.
CONSTITUTION: A compound shown by the formula I (R is alkyl) is reacted with a compound shown by the formula II (X and Y are halogen; R1 is alkyl, aryl, or aralkyl) in a solvent, preferably hydrocarbon, ether, dimethylformamide, etc. in the presence of a base, e.g., triethylamine, etc. at 50W150°CC. The prepared reaction product is reduced with a reducing agent, e.g., stannous chloride, sodium boron hydride, etc. in the presence of a catalyst (e.g., platinum, palladium, nickel, etc.) to give the disired substance shown by the formula III. A compound obtained by hydrolyzing the desired compound has β-adrenergic neuronal blocking actions and is useful for remedying and preventing arrhythmia, atrial fibrillation, and coronatitis.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7912680A JPS574986A (en) | 1980-06-13 | 1980-06-13 | Preparation of oxazolidine derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7912680A JPS574986A (en) | 1980-06-13 | 1980-06-13 | Preparation of oxazolidine derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS574986A true JPS574986A (en) | 1982-01-11 |
Family
ID=13681238
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7912680A Pending JPS574986A (en) | 1980-06-13 | 1980-06-13 | Preparation of oxazolidine derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS574986A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5399574A (en) * | 1990-06-07 | 1995-03-21 | Burroughs Wellcome Co. | Indolyl tetrahydropyridines for treating migraine |
-
1980
- 1980-06-13 JP JP7912680A patent/JPS574986A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5399574A (en) * | 1990-06-07 | 1995-03-21 | Burroughs Wellcome Co. | Indolyl tetrahydropyridines for treating migraine |
US5466699A (en) * | 1990-06-07 | 1995-11-14 | Burroughs Wellcome Co. | Indolyl compounds for treating migraine |
US5863935A (en) * | 1990-06-07 | 1999-01-26 | Zeneca Limited | Therapeutic heterocyclic compounds |
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