JPS574986A - Preparation of oxazolidine derivative - Google Patents

Preparation of oxazolidine derivative

Info

Publication number
JPS574986A
JPS574986A JP7912680A JP7912680A JPS574986A JP S574986 A JPS574986 A JP S574986A JP 7912680 A JP7912680 A JP 7912680A JP 7912680 A JP7912680 A JP 7912680A JP S574986 A JPS574986 A JP S574986A
Authority
JP
Japan
Prior art keywords
compound
formula
alkyl
derivative
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP7912680A
Other languages
Japanese (ja)
Inventor
Kiyonori Yokogoshi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PAAMAKEMU ASIA KK
Permachem Asia Ltd
Original Assignee
PAAMAKEMU ASIA KK
Permachem Asia Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PAAMAKEMU ASIA KK, Permachem Asia Ltd filed Critical PAAMAKEMU ASIA KK
Priority to JP7912680A priority Critical patent/JPS574986A/en
Publication of JPS574986A publication Critical patent/JPS574986A/en
Pending legal-status Critical Current

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  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE: To obtain the titled compound in high yield useful as an intermediate for synthesizing drugs, by reacting a methylnitrophenol derivative of oxazolidine with a substituted formamide derivative, followed by reduction.
CONSTITUTION: A compound shown by the formula I (R is alkyl) is reacted with a compound shown by the formula II (X and Y are halogen; R1 is alkyl, aryl, or aralkyl) in a solvent, preferably hydrocarbon, ether, dimethylformamide, etc. in the presence of a base, e.g., triethylamine, etc. at 50W150°CC. The prepared reaction product is reduced with a reducing agent, e.g., stannous chloride, sodium boron hydride, etc. in the presence of a catalyst (e.g., platinum, palladium, nickel, etc.) to give the disired substance shown by the formula III. A compound obtained by hydrolyzing the desired compound has β-adrenergic neuronal blocking actions and is useful for remedying and preventing arrhythmia, atrial fibrillation, and coronatitis.
COPYRIGHT: (C)1982,JPO&Japio
JP7912680A 1980-06-13 1980-06-13 Preparation of oxazolidine derivative Pending JPS574986A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP7912680A JPS574986A (en) 1980-06-13 1980-06-13 Preparation of oxazolidine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7912680A JPS574986A (en) 1980-06-13 1980-06-13 Preparation of oxazolidine derivative

Publications (1)

Publication Number Publication Date
JPS574986A true JPS574986A (en) 1982-01-11

Family

ID=13681238

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7912680A Pending JPS574986A (en) 1980-06-13 1980-06-13 Preparation of oxazolidine derivative

Country Status (1)

Country Link
JP (1) JPS574986A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5399574A (en) * 1990-06-07 1995-03-21 Burroughs Wellcome Co. Indolyl tetrahydropyridines for treating migraine

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5399574A (en) * 1990-06-07 1995-03-21 Burroughs Wellcome Co. Indolyl tetrahydropyridines for treating migraine
US5466699A (en) * 1990-06-07 1995-11-14 Burroughs Wellcome Co. Indolyl compounds for treating migraine
US5863935A (en) * 1990-06-07 1999-01-26 Zeneca Limited Therapeutic heterocyclic compounds

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