JPS56125361A - Azetidinone compound - Google Patents
Azetidinone compoundInfo
- Publication number
- JPS56125361A JPS56125361A JP2805980A JP2805980A JPS56125361A JP S56125361 A JPS56125361 A JP S56125361A JP 2805980 A JP2805980 A JP 2805980A JP 2805980 A JP2805980 A JP 2805980A JP S56125361 A JPS56125361 A JP S56125361A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- solvent
- azido
- benzene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:Compounds of formula I', formula I" and I'''(Ar is aromatic group; R1 is H, alkyl, or aryl; R2 is alkyl or aryl; X' is benzyloxy or azido; X" is OH or amino; X''' is acylamino).
EXAMPLE: 1-(1-Methoxycarbonylbenzyl)-3-azido-4-phenylazetidin-2-one.
USE: Raw material for the preparation of dipeptide.
PROCESS: Reaction of a Schiff base of formula II with a compound of formula III (Y is halogen or OH) in a solvent such as benzene, in the presence of a tert-amine such as triethylamine at -78W+100°C, affords a compound of formula I', whih can be converted to a compound of formula I" by the hydrogenative decomposition in a solvent such as methanol, in the presence of a catalyst such as Pd black at room temp. W150°C. A compound of the formula I" can be prepared by reacting a compound of formula I" wherein X" is amino with an acid chloride or an acid anhydride in a solvent such as benzene at -30°C Wroom temp.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2805980A JPS56125361A (en) | 1980-03-07 | 1980-03-07 | Azetidinone compound |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2805980A JPS56125361A (en) | 1980-03-07 | 1980-03-07 | Azetidinone compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS56125361A true JPS56125361A (en) | 1981-10-01 |
Family
ID=12238181
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2805980A Pending JPS56125361A (en) | 1980-03-07 | 1980-03-07 | Azetidinone compound |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS56125361A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5953465A (en) * | 1982-08-19 | 1984-03-28 | エフ・ホフマン―ラ ロシユ アーゲー | Beta-lactams |
| JPS6036458A (en) * | 1983-08-08 | 1985-02-25 | Sumitomo Chem Co Ltd | Preparation of beta-lactam derivative |
| JPH029862A (en) * | 1988-06-27 | 1990-01-12 | Sankyo Co Ltd | Production of azetidinone derivative |
| WO2007011878A2 (en) * | 2005-07-19 | 2007-01-25 | Azevan Pharmaceuticals, Inc. | Beta-lactamyl phenylalanine, cysteine, and serine vasopressin antagonists |
| US9376424B2 (en) | 2010-07-01 | 2016-06-28 | Azevan Pharmaceuticals, Inc. | Methods for treating post traumatic stress disorder |
| US9597314B2 (en) | 2005-03-22 | 2017-03-21 | Azevan Pharmaceuticals, Inc. | Beta-lactamylalkanoic acids for treating premenstrual disorders |
| US9802925B2 (en) | 2014-03-28 | 2017-10-31 | Azevan Pharmaceuticals, Inc. | Compositions and methods for treating neurodegenerative diseases |
| US11628160B2 (en) | 2017-09-15 | 2023-04-18 | Azevan Pharmaceuticals, Inc. | Compositions and methods for treating brain injury |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2645085A1 (en) * | 1975-10-06 | 1977-04-14 | Fujisawa Pharmaceutical Co | 2-ACETIDINONE COMPOUNDS AND METHOD FOR THEIR PRODUCTION |
| US4140688A (en) * | 1978-04-03 | 1979-02-20 | Smithkline Corporation | Tricyclic (azeto-isoquinoline) β-lactams |
-
1980
- 1980-03-07 JP JP2805980A patent/JPS56125361A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2645085A1 (en) * | 1975-10-06 | 1977-04-14 | Fujisawa Pharmaceutical Co | 2-ACETIDINONE COMPOUNDS AND METHOD FOR THEIR PRODUCTION |
| US4140688A (en) * | 1978-04-03 | 1979-02-20 | Smithkline Corporation | Tricyclic (azeto-isoquinoline) β-lactams |
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5953465A (en) * | 1982-08-19 | 1984-03-28 | エフ・ホフマン―ラ ロシユ アーゲー | Beta-lactams |
| JPH0587515B2 (en) * | 1982-08-19 | 1993-12-16 | Hoffmann La Roche | |
| JPS6036458A (en) * | 1983-08-08 | 1985-02-25 | Sumitomo Chem Co Ltd | Preparation of beta-lactam derivative |
| JPH029862A (en) * | 1988-06-27 | 1990-01-12 | Sankyo Co Ltd | Production of azetidinone derivative |
| US9597314B2 (en) | 2005-03-22 | 2017-03-21 | Azevan Pharmaceuticals, Inc. | Beta-lactamylalkanoic acids for treating premenstrual disorders |
| US8426400B2 (en) | 2005-07-19 | 2013-04-23 | Azevan Pharmaceuticals, Inc. | β-lactamyl phenylalanine, cysteine, and serine vasopressin antagonists |
| WO2007011878A2 (en) * | 2005-07-19 | 2007-01-25 | Azevan Pharmaceuticals, Inc. | Beta-lactamyl phenylalanine, cysteine, and serine vasopressin antagonists |
| US8048874B2 (en) | 2005-07-19 | 2011-11-01 | Azevan Pharmaceuticals, Inc. | Beta-lactamyl phenylalanine, cysteine, and serine vasopressin antagonists |
| WO2007011878A3 (en) * | 2005-07-19 | 2007-09-07 | Azevan Pharmaceuticals Inc | Beta-lactamyl phenylalanine, cysteine, and serine vasopressin antagonists |
| AU2006270039B2 (en) * | 2005-07-19 | 2013-07-04 | Azevan Pharmaceuticals, Inc. | Beta-lactamyl phenylalanine, cysteine, and serine vasopressin antagonists |
| JP2013151520A (en) * | 2005-07-19 | 2013-08-08 | Azevan Pharmaceuticals Inc | Beta-lactamyl phenylalanine, cysteine, and serine vasopressin antagonist |
| KR101523776B1 (en) * | 2005-07-19 | 2015-05-28 | 아제반 파마슈티칼스, 인코퍼레이티드 | Beta-lactamyl phenylalanine, cysteine, and serine vasopressin antagonists |
| JP2009502788A (en) * | 2005-07-19 | 2009-01-29 | アゼヴァン ファーマスーティカルズ，インコーポレイテッド | Beta-lactamphenylalanine, cysteine, and serine vasopressin antagonist |
| US9376424B2 (en) | 2010-07-01 | 2016-06-28 | Azevan Pharmaceuticals, Inc. | Methods for treating post traumatic stress disorder |
| US9987265B2 (en) | 2010-07-01 | 2018-06-05 | Azevan Pharmaceuticals, Inc. | Methods for treating post traumatic stress disorder |
| US9802925B2 (en) | 2014-03-28 | 2017-10-31 | Azevan Pharmaceuticals, Inc. | Compositions and methods for treating neurodegenerative diseases |
| US10364236B2 (en) | 2014-03-28 | 2019-07-30 | Azevan Pharmaceuticals, Inc. | Compositions and methods for treating neurodegenerative diseases |
| US11319306B2 (en) | 2014-03-28 | 2022-05-03 | Azevan Pharmaceuticals, Inc. | Compositions and methods for treating neurodegenerative diseases |
| US11628160B2 (en) | 2017-09-15 | 2023-04-18 | Azevan Pharmaceuticals, Inc. | Compositions and methods for treating brain injury |
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