JPS5629547A - Preparation of 1-aryloxy-3-isopropylamino-2-propanol - Google Patents
Preparation of 1-aryloxy-3-isopropylamino-2-propanolInfo
- Publication number
- JPS5629547A JPS5629547A JP10535379A JP10535379A JPS5629547A JP S5629547 A JPS5629547 A JP S5629547A JP 10535379 A JP10535379 A JP 10535379A JP 10535379 A JP10535379 A JP 10535379A JP S5629547 A JPS5629547 A JP S5629547A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- product
- isopropylamine
- decomposing
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To prepare the titled compound, easily, in high yield, in a short time, at a low temperature, by reacting a specific epoxide compound with an equimolar amunt of an isopropylamine metal amide, and decomposing the reaction product with an aqueous solution of NH4Cl or treating the reaction product with a protonic solvent.
CONSTITUTION: The titled compound of formula II is prepared by (1) reacting an amide of formula MNHCH(CH3)2 [M is MgX (X is Cl, Br, or I), Li, or SiR3 (R is Ch3 or C2H5)] with a 1-aryloxy-2,3-propylene oxide of formula I (Ar is 1-naphthyl or 4-indolyl), and (2) decomposing the product with aqueous solution of ammonium chloride or treating the product simply with a protonic solvent such as methanol, ethanol, acetic acid, water, etc. The reactivity of the low-reactive isopropylamine can be remarkably increased by converting to the metal amide. The reaction can be carried out without using particular apparatus and emitting ill odor.
USE: Remedy for arrhythmic auricular fibrillation and the diseases of the coronary vessel.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10535379A JPS5629547A (en) | 1979-08-18 | 1979-08-18 | Preparation of 1-aryloxy-3-isopropylamino-2-propanol |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10535379A JPS5629547A (en) | 1979-08-18 | 1979-08-18 | Preparation of 1-aryloxy-3-isopropylamino-2-propanol |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5629547A true JPS5629547A (en) | 1981-03-24 |
JPS5735900B2 JPS5735900B2 (en) | 1982-07-31 |
Family
ID=14405356
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10535379A Granted JPS5629547A (en) | 1979-08-18 | 1979-08-18 | Preparation of 1-aryloxy-3-isopropylamino-2-propanol |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5629547A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57169448A (en) * | 1981-03-31 | 1982-10-19 | Ciba Geigy Ag | Manufacture of substituted phenyl ether |
EP0467637A1 (en) * | 1990-07-18 | 1992-01-22 | Senju Pharmaceutical Co., Ltd. | Pyrazolo(1,5-a)pyridine compounds, and production and use thereof |
-
1979
- 1979-08-18 JP JP10535379A patent/JPS5629547A/en active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57169448A (en) * | 1981-03-31 | 1982-10-19 | Ciba Geigy Ag | Manufacture of substituted phenyl ether |
EP0467637A1 (en) * | 1990-07-18 | 1992-01-22 | Senju Pharmaceutical Co., Ltd. | Pyrazolo(1,5-a)pyridine compounds, and production and use thereof |
Also Published As
Publication number | Publication date |
---|---|
JPS5735900B2 (en) | 1982-07-31 |
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