JPS5629547A - Preparation of 1-aryloxy-3-isopropylamino-2-propanol - Google Patents

Preparation of 1-aryloxy-3-isopropylamino-2-propanol

Info

Publication number
JPS5629547A
JPS5629547A JP10535379A JP10535379A JPS5629547A JP S5629547 A JPS5629547 A JP S5629547A JP 10535379 A JP10535379 A JP 10535379A JP 10535379 A JP10535379 A JP 10535379A JP S5629547 A JPS5629547 A JP S5629547A
Authority
JP
Japan
Prior art keywords
formula
product
isopropylamine
decomposing
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10535379A
Other languages
Japanese (ja)
Other versions
JPS5735900B2 (en
Inventor
Tsutomu Kunishige
Akira Matsuyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to JP10535379A priority Critical patent/JPS5629547A/en
Publication of JPS5629547A publication Critical patent/JPS5629547A/en
Publication of JPS5735900B2 publication Critical patent/JPS5735900B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To prepare the titled compound, easily, in high yield, in a short time, at a low temperature, by reacting a specific epoxide compound with an equimolar amunt of an isopropylamine metal amide, and decomposing the reaction product with an aqueous solution of NH4Cl or treating the reaction product with a protonic solvent.
CONSTITUTION: The titled compound of formula II is prepared by (1) reacting an amide of formula MNHCH(CH3)2 [M is MgX (X is Cl, Br, or I), Li, or SiR3 (R is Ch3 or C2H5)] with a 1-aryloxy-2,3-propylene oxide of formula I (Ar is 1-naphthyl or 4-indolyl), and (2) decomposing the product with aqueous solution of ammonium chloride or treating the product simply with a protonic solvent such as methanol, ethanol, acetic acid, water, etc. The reactivity of the low-reactive isopropylamine can be remarkably increased by converting to the metal amide. The reaction can be carried out without using particular apparatus and emitting ill odor.
USE: Remedy for arrhythmic auricular fibrillation and the diseases of the coronary vessel.
COPYRIGHT: (C)1981,JPO&Japio
JP10535379A 1979-08-18 1979-08-18 Preparation of 1-aryloxy-3-isopropylamino-2-propanol Granted JPS5629547A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10535379A JPS5629547A (en) 1979-08-18 1979-08-18 Preparation of 1-aryloxy-3-isopropylamino-2-propanol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10535379A JPS5629547A (en) 1979-08-18 1979-08-18 Preparation of 1-aryloxy-3-isopropylamino-2-propanol

Publications (2)

Publication Number Publication Date
JPS5629547A true JPS5629547A (en) 1981-03-24
JPS5735900B2 JPS5735900B2 (en) 1982-07-31

Family

ID=14405356

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10535379A Granted JPS5629547A (en) 1979-08-18 1979-08-18 Preparation of 1-aryloxy-3-isopropylamino-2-propanol

Country Status (1)

Country Link
JP (1) JPS5629547A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57169448A (en) * 1981-03-31 1982-10-19 Ciba Geigy Ag Manufacture of substituted phenyl ether
EP0467637A1 (en) * 1990-07-18 1992-01-22 Senju Pharmaceutical Co., Ltd. Pyrazolo(1,5-a)pyridine compounds, and production and use thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57169448A (en) * 1981-03-31 1982-10-19 Ciba Geigy Ag Manufacture of substituted phenyl ether
EP0467637A1 (en) * 1990-07-18 1992-01-22 Senju Pharmaceutical Co., Ltd. Pyrazolo(1,5-a)pyridine compounds, and production and use thereof

Also Published As

Publication number Publication date
JPS5735900B2 (en) 1982-07-31

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