JPS55133357A - Preparation of 1-cyano-2-hydroxy-3-phthalimidopropane - Google Patents
Preparation of 1-cyano-2-hydroxy-3-phthalimidopropaneInfo
- Publication number
- JPS55133357A JPS55133357A JP3994279A JP3994279A JPS55133357A JP S55133357 A JPS55133357 A JP S55133357A JP 3994279 A JP3994279 A JP 3994279A JP 3994279 A JP3994279 A JP 3994279A JP S55133357 A JPS55133357 A JP S55133357A
- Authority
- JP
- Japan
- Prior art keywords
- phthalimide
- epichlorohydrin
- phthalimidopropane
- hydroxy
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Indole Compounds (AREA)
Abstract
PURPOSE: To obtain the high purity title compound in high yield without the specific preparation of a catalyst, the reaction of epichlorohydrin and phthalimide in the presence of an excess amount of epichlorohydrin using a metal salt of phthalimide as a catalyst.
CONSTITUTION: The reaction of epichlorohydrin and phthalimide gives 1-chloro-2- hydroxy-3-phthalimidopropane, to which a cyanide is added to afford the title compound. The reaction is carried out in the presence of an excess amount of epichlorohydrin, using a metal salt of phthalimide (e.g. Na salt, K salt, etc. of phthalimide) as a catalyst. The yield of 1-chloro-2-hydroxy-3-phthalimidopropane is 88W95%. The yield of the title compound is 86W92% and the purity is 98%. The reaction process can be simplified and the isolation is facilitated.
USE: Intermediate of γ-amino-β-hydroxybutyric acid.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3994279A JPS55133357A (en) | 1979-04-02 | 1979-04-02 | Preparation of 1-cyano-2-hydroxy-3-phthalimidopropane |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3994279A JPS55133357A (en) | 1979-04-02 | 1979-04-02 | Preparation of 1-cyano-2-hydroxy-3-phthalimidopropane |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS55133357A true JPS55133357A (en) | 1980-10-17 |
| JPS6317060B2 JPS6317060B2 (en) | 1988-04-12 |
Family
ID=12566999
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3994279A Granted JPS55133357A (en) | 1979-04-02 | 1979-04-02 | Preparation of 1-cyano-2-hydroxy-3-phthalimidopropane |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS55133357A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999024393A1 (en) * | 1997-11-07 | 1999-05-20 | Pharmacia & Upjohn Company | Process to produce oxazolidinones |
| JP2009185047A (en) * | 2002-09-25 | 2009-08-20 | Daiso Co Ltd | Method for producing glycidylphthalimide |
-
1979
- 1979-04-02 JP JP3994279A patent/JPS55133357A/en active Granted
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999024393A1 (en) * | 1997-11-07 | 1999-05-20 | Pharmacia & Upjohn Company | Process to produce oxazolidinones |
| EP1772453A1 (en) * | 1997-11-07 | 2007-04-11 | Pharmacia & Upjohn Company LLC | Process to produce Oxazolidinones |
| JP2009185047A (en) * | 2002-09-25 | 2009-08-20 | Daiso Co Ltd | Method for producing glycidylphthalimide |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6317060B2 (en) | 1988-04-12 |
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