JPS5690033A - 1,3-disubstituted cyclohexene derivative - Google Patents

1,3-disubstituted cyclohexene derivative

Info

Publication number
JPS5690033A
JPS5690033A JP16683879A JP16683879A JPS5690033A JP S5690033 A JPS5690033 A JP S5690033A JP 16683879 A JP16683879 A JP 16683879A JP 16683879 A JP16683879 A JP 16683879A JP S5690033 A JPS5690033 A JP S5690033A
Authority
JP
Japan
Prior art keywords
formula
solvent
compound
temp
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP16683879A
Other languages
Japanese (ja)
Inventor
Kiyohide Matsui
Akira Negishi
Akemi Tanaka
Etsuko Kasai
Sei Kondo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
Original Assignee
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sagami Chemical Research Institute filed Critical Sagami Chemical Research Institute
Priority to JP16683879A priority Critical patent/JPS5690033A/en
Publication of JPS5690033A publication Critical patent/JPS5690033A/en
Pending legal-status Critical Current

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:A compound of formula I [Ar is aryl; R1 is H or lower alkyl; R2 and R3 are H, cyano, or -CO2R4 (R4 is lower alkyl); X1 and X2 are H or halogen].
EXAMPLE: Dimethyl 3-benzoyl-2-cyclohexen-1-ylmalonate.
USE: Raw material for the preparation of ketoprofen having lenitive and anti-inflammatory activities and its analogs.
PROCESS: 1-Aroylcyclohexene of formula II is halogenated with a halogenating agent, e.g. bromine, in a solvent at room temp. W reflux temp. of the solvent to give 1-aroyl-3-halogenocyclohexene of formula III. The compound obtained is made to react with a compound of formula IV preferably in a solvent at room temp. W reflux temp. of the solvent in the presence of a base, e.g. NaH, to afford a compound of formula I wherein both X1 and X2 are H.
COPYRIGHT: (C)1981,JPO&Japio
JP16683879A 1979-12-24 1979-12-24 1,3-disubstituted cyclohexene derivative Pending JPS5690033A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP16683879A JPS5690033A (en) 1979-12-24 1979-12-24 1,3-disubstituted cyclohexene derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16683879A JPS5690033A (en) 1979-12-24 1979-12-24 1,3-disubstituted cyclohexene derivative

Publications (1)

Publication Number Publication Date
JPS5690033A true JPS5690033A (en) 1981-07-21

Family

ID=15838586

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16683879A Pending JPS5690033A (en) 1979-12-24 1979-12-24 1,3-disubstituted cyclohexene derivative

Country Status (1)

Country Link
JP (1) JPS5690033A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11322645A (en) * 1998-05-15 1999-11-24 Asahi Chem Ind Co Ltd Chlorination of cycloalkene

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11322645A (en) * 1998-05-15 1999-11-24 Asahi Chem Ind Co Ltd Chlorination of cycloalkene

Similar Documents

Publication Publication Date Title
JPS5432460A (en) Cycloalkylidenemethylphenylacetic acid derivative and their preparation
JPS57116074A (en) Novel camptothecin derivative and its preparation
JPS5690033A (en) 1,3-disubstituted cyclohexene derivative
JPS5728046A (en) Preparation of 4-substituted indole
JPS5639062A (en) Slufenamide derivative
JPS5630979A (en) Pyranoindolizine derivative and its preparation
JPS5665838A (en) Preparation of beta-alkoxymethoxymethyl halide
JPS55104274A (en) Isoxazolin-3-one derivative and its preparation
JPS5639081A (en) Benzthiazepine derivative
JPS5566560A (en) Quinolone derivative
JPS55164682A (en) 1-alkyl-2-oxo-2h-1,8-naphthyridine derivative and its preparation
JPS5661330A (en) 2-methoxy-4-alkoxycarbonyl-5-halobenzoyl chloride and its preparation
JPS5661365A (en) Dimethoxyphthalazinone derivative and its preparation
JPS54130599A (en) Furoindole derivative
JPS5643271A (en) Production of 4-benzoyl-5-hydroxypyrazole
JPS57136578A (en) Oxamide derivative, its preparation, and pharmaceutical composition containing the same
JPS5695165A (en) Preparation of substituted benzoic acid amide
JPS5278888A (en) Synthesis of novel quinazoline derivatives
JPS54106498A (en) Carbostyril derivative
JPS5629581A (en) 4-phenylpiperazinyl alkoxy anilide derivative
JPS55136293A (en) Thiazolo 3,2-a pyrimidine derivative and its preparation
JPS5690035A (en) Cyclohexylidene acetic acid derivative
JPS5527142A (en) Novel 1-phthalazone derivative
JPS56113771A (en) N,n'-disubstituted diazacycloalkane derivative
JPS55108857A (en) Preparation of 5-fluorouracil derivative