JPS56113771A - N,n'-disubstituted diazacycloalkane derivative - Google Patents

N,n'-disubstituted diazacycloalkane derivative

Info

Publication number
JPS56113771A
JPS56113771A JP1602580A JP1602580A JPS56113771A JP S56113771 A JPS56113771 A JP S56113771A JP 1602580 A JP1602580 A JP 1602580A JP 1602580 A JP1602580 A JP 1602580A JP S56113771 A JPS56113771 A JP S56113771A
Authority
JP
Japan
Prior art keywords
formula
disubstituted
bis
compound
diazacycloalkane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1602580A
Other languages
Japanese (ja)
Other versions
JPS6317069B2 (en
Inventor
Eiichi Etsuchu
Nobuo Ogawa
Sakae Kurata
Terusato Yamagishi
Hideo Kato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Japan Co Ltd
Original Assignee
Hokuriku Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hokuriku Pharmaceutical Co Ltd filed Critical Hokuriku Pharmaceutical Co Ltd
Priority to JP1602580A priority Critical patent/JPS56113771A/en
Publication of JPS56113771A publication Critical patent/JPS56113771A/en
Publication of JPS6317069B2 publication Critical patent/JPS6317069B2/ja
Granted legal-status Critical Current

Links

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:An N,N'-disubstituted diazacycloalkane derivative of formula I (R is acetyl or ethoxycarbonyl; n is 2 or 3; m is 2 or 3) and an acid addition salt thereof.
EXAMPLE: N, N'-Bis-[ 2-( 3, 5- dimethoxy-4- ethoxycarbonyloxybenzoyloxy)ethyl ] piperazine.
USE: Useful as a medicine having a vasodilator action.
PROCESS: An N,N'-bis-hydroxyalkyl compound of formula II is reacted with a benzoyl halogenide of formula III (X is halogen, particularly chlorine or bromine) in an anhydrous inert organic solvent, e.g. acetone or ether, in the presence of a tertiary amine as a deacidifying agent, preferably at a reflux temperature of the solvent to be used, to give the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP1602580A 1980-02-14 1980-02-14 N,n'-disubstituted diazacycloalkane derivative Granted JPS56113771A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP1602580A JPS56113771A (en) 1980-02-14 1980-02-14 N,n'-disubstituted diazacycloalkane derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1602580A JPS56113771A (en) 1980-02-14 1980-02-14 N,n'-disubstituted diazacycloalkane derivative

Publications (2)

Publication Number Publication Date
JPS56113771A true JPS56113771A (en) 1981-09-07
JPS6317069B2 JPS6317069B2 (en) 1988-04-12

Family

ID=11905018

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1602580A Granted JPS56113771A (en) 1980-02-14 1980-02-14 N,n'-disubstituted diazacycloalkane derivative

Country Status (1)

Country Link
JP (1) JPS56113771A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4751298A (en) * 1984-02-03 1988-06-14 Degussa Aktiengesellschaft Production of 1-(3-hydroxy-propyl)-1,4-diazepane and 1,4-bis(3,4,5-trimethoxy-benzoyloxy)-propyl-diazepane derivatives thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4751298A (en) * 1984-02-03 1988-06-14 Degussa Aktiengesellschaft Production of 1-(3-hydroxy-propyl)-1,4-diazepane and 1,4-bis(3,4,5-trimethoxy-benzoyloxy)-propyl-diazepane derivatives thereof

Also Published As

Publication number Publication date
JPS6317069B2 (en) 1988-04-12

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