JPS56113771A - N,n'-disubstituted diazacycloalkane derivative - Google Patents
N,n'-disubstituted diazacycloalkane derivativeInfo
- Publication number
- JPS56113771A JPS56113771A JP1602580A JP1602580A JPS56113771A JP S56113771 A JPS56113771 A JP S56113771A JP 1602580 A JP1602580 A JP 1602580A JP 1602580 A JP1602580 A JP 1602580A JP S56113771 A JPS56113771 A JP S56113771A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- disubstituted
- bis
- compound
- diazacycloalkane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:An N,N'-disubstituted diazacycloalkane derivative of formula I (R is acetyl or ethoxycarbonyl; n is 2 or 3; m is 2 or 3) and an acid addition salt thereof.
EXAMPLE: N, N'-Bis-[ 2-( 3, 5- dimethoxy-4- ethoxycarbonyloxybenzoyloxy)ethyl ] piperazine.
USE: Useful as a medicine having a vasodilator action.
PROCESS: An N,N'-bis-hydroxyalkyl compound of formula II is reacted with a benzoyl halogenide of formula III (X is halogen, particularly chlorine or bromine) in an anhydrous inert organic solvent, e.g. acetone or ether, in the presence of a tertiary amine as a deacidifying agent, preferably at a reflux temperature of the solvent to be used, to give the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1602580A JPS56113771A (en) | 1980-02-14 | 1980-02-14 | N,n'-disubstituted diazacycloalkane derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1602580A JPS56113771A (en) | 1980-02-14 | 1980-02-14 | N,n'-disubstituted diazacycloalkane derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS56113771A true JPS56113771A (en) | 1981-09-07 |
JPS6317069B2 JPS6317069B2 (en) | 1988-04-12 |
Family
ID=11905018
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1602580A Granted JPS56113771A (en) | 1980-02-14 | 1980-02-14 | N,n'-disubstituted diazacycloalkane derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56113771A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4751298A (en) * | 1984-02-03 | 1988-06-14 | Degussa Aktiengesellschaft | Production of 1-(3-hydroxy-propyl)-1,4-diazepane and 1,4-bis(3,4,5-trimethoxy-benzoyloxy)-propyl-diazepane derivatives thereof |
-
1980
- 1980-02-14 JP JP1602580A patent/JPS56113771A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4751298A (en) * | 1984-02-03 | 1988-06-14 | Degussa Aktiengesellschaft | Production of 1-(3-hydroxy-propyl)-1,4-diazepane and 1,4-bis(3,4,5-trimethoxy-benzoyloxy)-propyl-diazepane derivatives thereof |
Also Published As
Publication number | Publication date |
---|---|
JPS6317069B2 (en) | 1988-04-12 |
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