JPS5461185A - Nucleic acid base derivatives - Google Patents
Nucleic acid base derivativesInfo
- Publication number
- JPS5461185A JPS5461185A JP12851977A JP12851977A JPS5461185A JP S5461185 A JPS5461185 A JP S5461185A JP 12851977 A JP12851977 A JP 12851977A JP 12851977 A JP12851977 A JP 12851977A JP S5461185 A JPS5461185 A JP S5461185A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compounds
- nucleic acid
- acid base
- residue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
Abstract
NEW MATERIAL:Nucleic acid base derivatives of formula I: (X is -CH2- or O; R1 is residue of natural nucleic acid base; N-R2 is a residue of lysine or arginine at the ω-amino group).
EXAMPLE: Compound of formula I: (R1 is guanine residue; R2 is formula -(CH2)4CH(NH3)COOH; X is O).
USE: Oncostatic agents having a powerful oncostatic action and low toxicity.
PROCESS: Compounds of formula II are suspended or dissolved in water or an aqueous organic solvent, e.g. hydrous alcohol, hydrous dioxane, etc., and reactd with an almost equimolar amount (1.0Wabout 1,5 moles) of lysine or arginine at room temperature for 10 minW24Hr to give compounds of formula I. The compounds of formula II can be readily obtained by oxidation of compounds of formula III with periodic acid.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12851977A JPS5461185A (en) | 1977-10-25 | 1977-10-25 | Nucleic acid base derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12851977A JPS5461185A (en) | 1977-10-25 | 1977-10-25 | Nucleic acid base derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5461185A true JPS5461185A (en) | 1979-05-17 |
Family
ID=14986738
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12851977A Pending JPS5461185A (en) | 1977-10-25 | 1977-10-25 | Nucleic acid base derivatives |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5461185A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0123473A2 (en) * | 1983-04-25 | 1984-10-31 | Fujisawa Pharmaceutical Co., Ltd. | Morpholine derivatives, processes for the preparation thereof, the use thereof and pharmaceutical compositions containing them |
WO1991018898A1 (en) * | 1990-06-01 | 1991-12-12 | Nippon Shinyaku Co., Ltd. | Nucleic acid homolog |
-
1977
- 1977-10-25 JP JP12851977A patent/JPS5461185A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0123473A2 (en) * | 1983-04-25 | 1984-10-31 | Fujisawa Pharmaceutical Co., Ltd. | Morpholine derivatives, processes for the preparation thereof, the use thereof and pharmaceutical compositions containing them |
WO1991018898A1 (en) * | 1990-06-01 | 1991-12-12 | Nippon Shinyaku Co., Ltd. | Nucleic acid homolog |
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