JPS5461185A - Nucleic acid base derivatives - Google Patents

Nucleic acid base derivatives

Info

Publication number
JPS5461185A
JPS5461185A JP12851977A JP12851977A JPS5461185A JP S5461185 A JPS5461185 A JP S5461185A JP 12851977 A JP12851977 A JP 12851977A JP 12851977 A JP12851977 A JP 12851977A JP S5461185 A JPS5461185 A JP S5461185A
Authority
JP
Japan
Prior art keywords
formula
compounds
nucleic acid
acid base
residue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP12851977A
Other languages
Japanese (ja)
Inventor
Hiroshi Akimoto
Yoshio Kozai
Masaaki Nomura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP12851977A priority Critical patent/JPS5461185A/en
Publication of JPS5461185A publication Critical patent/JPS5461185A/en
Pending legal-status Critical Current

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  • Plural Heterocyclic Compounds (AREA)

Abstract

NEW MATERIAL:Nucleic acid base derivatives of formula I: (X is -CH2- or O; R1 is residue of natural nucleic acid base; N-R2 is a residue of lysine or arginine at the ω-amino group).
EXAMPLE: Compound of formula I: (R1 is guanine residue; R2 is formula -(CH2)4CH(NH3)COOH; X is O).
USE: Oncostatic agents having a powerful oncostatic action and low toxicity.
PROCESS: Compounds of formula II are suspended or dissolved in water or an aqueous organic solvent, e.g. hydrous alcohol, hydrous dioxane, etc., and reactd with an almost equimolar amount (1.0Wabout 1,5 moles) of lysine or arginine at room temperature for 10 minW24Hr to give compounds of formula I. The compounds of formula II can be readily obtained by oxidation of compounds of formula III with periodic acid.
COPYRIGHT: (C)1979,JPO&Japio
JP12851977A 1977-10-25 1977-10-25 Nucleic acid base derivatives Pending JPS5461185A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12851977A JPS5461185A (en) 1977-10-25 1977-10-25 Nucleic acid base derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12851977A JPS5461185A (en) 1977-10-25 1977-10-25 Nucleic acid base derivatives

Publications (1)

Publication Number Publication Date
JPS5461185A true JPS5461185A (en) 1979-05-17

Family

ID=14986738

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12851977A Pending JPS5461185A (en) 1977-10-25 1977-10-25 Nucleic acid base derivatives

Country Status (1)

Country Link
JP (1) JPS5461185A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0123473A2 (en) * 1983-04-25 1984-10-31 Fujisawa Pharmaceutical Co., Ltd. Morpholine derivatives, processes for the preparation thereof, the use thereof and pharmaceutical compositions containing them
WO1991018898A1 (en) * 1990-06-01 1991-12-12 Nippon Shinyaku Co., Ltd. Nucleic acid homolog

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0123473A2 (en) * 1983-04-25 1984-10-31 Fujisawa Pharmaceutical Co., Ltd. Morpholine derivatives, processes for the preparation thereof, the use thereof and pharmaceutical compositions containing them
WO1991018898A1 (en) * 1990-06-01 1991-12-12 Nippon Shinyaku Co., Ltd. Nucleic acid homolog

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