JPS5659766A - Benzylpiperazine derivative - Google Patents

Benzylpiperazine derivative

Info

Publication number
JPS5659766A
JPS5659766A JP14338180A JP14338180A JPS5659766A JP S5659766 A JPS5659766 A JP S5659766A JP 14338180 A JP14338180 A JP 14338180A JP 14338180 A JP14338180 A JP 14338180A JP S5659766 A JPS5659766 A JP S5659766A
Authority
JP
Japan
Prior art keywords
formula
methyl
compound
substituted
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP14338180A
Other languages
Japanese (ja)
Other versions
JPS607990B2 (en
Inventor
Hiroshi Murai
Yoshiaki Aoyanagi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shinyaku Co Ltd
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Priority to JP55143381A priority Critical patent/JPS607990B2/en
Publication of JPS5659766A publication Critical patent/JPS5659766A/en
Publication of JPS607990B2 publication Critical patent/JPS607990B2/en
Expired legal-status Critical Current

Links

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:An N-substituted trialkoxybenzylpiperazine derivative shown by the formula I {R is methyl or ethyl; Z is -CH2C(OH)HA [A is a group shown by the formula II, III, or IV (Y is halogen, lower alkyl, lower alkoxy, benzyloxy, or OH)]}.
EXAMPLE: A compound shown by the formula I wherein R is methyl and Z is a group shown by the formula II.
USE: A remedy against ischemic malum cordis. Having coronary vasodilator action, inhibiting action of cardiomotility, etc.
PROCESS: For example, an N-trimethoxybenzylpiperazine shown by the formula V or N-triethoxybenzylpiperazine shown by the formula VI is reacted with a corresponding nuclear substituted phenylglycidyl ether of a halogenated compound optionally in the presence of an deoxidizer in a nonreactive solvent at room temperature to 100°C to give a compound shown by the formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP55143381A 1980-10-13 1980-10-13 Benzylpiperazine derivative Expired JPS607990B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP55143381A JPS607990B2 (en) 1980-10-13 1980-10-13 Benzylpiperazine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55143381A JPS607990B2 (en) 1980-10-13 1980-10-13 Benzylpiperazine derivative

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2744277A Division JPS53112886A (en) 1976-04-09 1977-03-12 Production of n-substituted trialkoxybenzylpiperazine derivative

Publications (2)

Publication Number Publication Date
JPS5659766A true JPS5659766A (en) 1981-05-23
JPS607990B2 JPS607990B2 (en) 1985-02-28

Family

ID=15337447

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55143381A Expired JPS607990B2 (en) 1980-10-13 1980-10-13 Benzylpiperazine derivative

Country Status (1)

Country Link
JP (1) JPS607990B2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5142053A (en) * 1990-04-20 1992-08-25 Adir Et Compagnie Process for the preparation of 1-(2,3,4-trimethoxybenzyl)piperazine by reductive animation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5142053A (en) * 1990-04-20 1992-08-25 Adir Et Compagnie Process for the preparation of 1-(2,3,4-trimethoxybenzyl)piperazine by reductive animation

Also Published As

Publication number Publication date
JPS607990B2 (en) 1985-02-28

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