JPS5659766A - Benzylpiperazine derivative - Google Patents
Benzylpiperazine derivativeInfo
- Publication number
- JPS5659766A JPS5659766A JP14338180A JP14338180A JPS5659766A JP S5659766 A JPS5659766 A JP S5659766A JP 14338180 A JP14338180 A JP 14338180A JP 14338180 A JP14338180 A JP 14338180A JP S5659766 A JPS5659766 A JP S5659766A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- methyl
- compound
- substituted
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:An N-substituted trialkoxybenzylpiperazine derivative shown by the formula I {R is methyl or ethyl; Z is -CH2C(OH)HA [A is a group shown by the formula II, III, or IV (Y is halogen, lower alkyl, lower alkoxy, benzyloxy, or OH)]}.
EXAMPLE: A compound shown by the formula I wherein R is methyl and Z is a group shown by the formula II.
USE: A remedy against ischemic malum cordis. Having coronary vasodilator action, inhibiting action of cardiomotility, etc.
PROCESS: For example, an N-trimethoxybenzylpiperazine shown by the formula V or N-triethoxybenzylpiperazine shown by the formula VI is reacted with a corresponding nuclear substituted phenylglycidyl ether of a halogenated compound optionally in the presence of an deoxidizer in a nonreactive solvent at room temperature to 100°C to give a compound shown by the formula I.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP55143381A JPS607990B2 (en) | 1980-10-13 | 1980-10-13 | Benzylpiperazine derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP55143381A JPS607990B2 (en) | 1980-10-13 | 1980-10-13 | Benzylpiperazine derivative |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2744277A Division JPS53112886A (en) | 1976-04-09 | 1977-03-12 | Production of n-substituted trialkoxybenzylpiperazine derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5659766A true JPS5659766A (en) | 1981-05-23 |
JPS607990B2 JPS607990B2 (en) | 1985-02-28 |
Family
ID=15337447
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP55143381A Expired JPS607990B2 (en) | 1980-10-13 | 1980-10-13 | Benzylpiperazine derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS607990B2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5142053A (en) * | 1990-04-20 | 1992-08-25 | Adir Et Compagnie | Process for the preparation of 1-(2,3,4-trimethoxybenzyl)piperazine by reductive animation |
-
1980
- 1980-10-13 JP JP55143381A patent/JPS607990B2/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5142053A (en) * | 1990-04-20 | 1992-08-25 | Adir Et Compagnie | Process for the preparation of 1-(2,3,4-trimethoxybenzyl)piperazine by reductive animation |
Also Published As
Publication number | Publication date |
---|---|
JPS607990B2 (en) | 1985-02-28 |
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