JPS57136578A - Oxamide derivative, its preparation, and pharmaceutical composition containing the same - Google Patents

Oxamide derivative, its preparation, and pharmaceutical composition containing the same

Info

Publication number
JPS57136578A
JPS57136578A JP632181A JP632181A JPS57136578A JP S57136578 A JPS57136578 A JP S57136578A JP 632181 A JP632181 A JP 632181A JP 632181 A JP632181 A JP 632181A JP S57136578 A JPS57136578 A JP S57136578A
Authority
JP
Japan
Prior art keywords
reaction
remedy
compound
preparation
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP632181A
Other languages
Japanese (ja)
Other versions
JPH0255427B2 (en
Inventor
Isao Sakano
Tatsuro Yokoyama
Seitaro Kajitani
Yutaka Okazaki
Hiroshi Tokuda
Hiroshi Kawamo
Mikio Kumakura
Takuo Nakano
Akira Awaya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Toatsu Chemicals Inc
Original Assignee
Mitsui Toatsu Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chemicals Inc filed Critical Mitsui Toatsu Chemicals Inc
Priority to JP632181A priority Critical patent/JPS57136578A/en
Priority to IT25957/81A priority patent/IT1142649B/en
Priority to US06/420,257 priority patent/US4501750A/en
Priority to DE8282900258T priority patent/DE3273781D1/en
Priority to EP82900258A priority patent/EP0069154B1/en
Priority to PCT/JP1982/000012 priority patent/WO1982002383A1/en
Publication of JPS57136578A publication Critical patent/JPS57136578A/en
Publication of JPH0255427B2 publication Critical patent/JPH0255427B2/ja
Granted legal-status Critical Current

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  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:The compound of formulaI(R1 is H, halogen, lower alkyl, lower alkoxy, phenoxy, nitro, or cyano; R2 is H, lower alkyl, or lower alkylthio).
EXAMPLE: N,N'-Bis(4-phenylthiazol-2-yl)oxamide.
USE: Medicine having immuno-regulating activity. Useful as a remedy for rheumatoid arthritis, remedy for viral diseases, and agent for carcinostatic immunotherapy.
PROCESS: The compound of formulaIis prepared by reacting 2-amino-4-phenylthiazoles of formula II with oxalyl chloride. The suitable reaction solvent is, e.g. benzene, THF, etc., and a base such as pyridine, sodium carbonate, etc. may be incorporated in the reaction system to remove hydrogen chloride produced by the reaction. Although the reaction proceeds at or below room temperature, the reaction system may be heated up to the boiling point of the solvent to accelerate the reaction.
COPYRIGHT: (C)1982,JPO&Japio
JP632181A 1981-01-08 1981-01-21 Oxamide derivative, its preparation, and pharmaceutical composition containing the same Granted JPS57136578A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP632181A JPS57136578A (en) 1981-01-21 1981-01-21 Oxamide derivative, its preparation, and pharmaceutical composition containing the same
IT25957/81A IT1142649B (en) 1981-01-08 1981-12-31 N 4 Phenyl 2 thiazolyl carbamate derivs.
US06/420,257 US4501750A (en) 1981-01-13 1982-01-13 Thiazole compounds, a process for preparing same and a pharmaceutical composition containing the thiazole compounds
DE8282900258T DE3273781D1 (en) 1981-01-13 1982-01-13 Novel thiazole compounds, process for their preparation, and medicinal composition containing same
EP82900258A EP0069154B1 (en) 1981-01-13 1982-01-13 Novel thiazole compounds, process for their preparation, and medicinal composition containing same
PCT/JP1982/000012 WO1982002383A1 (en) 1981-01-13 1982-01-13 Novel thiazole compounds,process for their preparation,and medicinal composition containing same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP632181A JPS57136578A (en) 1981-01-21 1981-01-21 Oxamide derivative, its preparation, and pharmaceutical composition containing the same

Publications (2)

Publication Number Publication Date
JPS57136578A true JPS57136578A (en) 1982-08-23
JPH0255427B2 JPH0255427B2 (en) 1990-11-27

Family

ID=11635093

Family Applications (1)

Application Number Title Priority Date Filing Date
JP632181A Granted JPS57136578A (en) 1981-01-08 1981-01-21 Oxamide derivative, its preparation, and pharmaceutical composition containing the same

Country Status (1)

Country Link
JP (1) JPS57136578A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0395755A (en) * 1989-09-07 1991-04-22 Mitsubishi Electric Corp Loading mechanism for magnetic recording and reproducing device
JPH03113863A (en) * 1989-09-27 1991-05-15 Mitsubishi Electric Corp Magnetic recording and reproducing device

Also Published As

Publication number Publication date
JPH0255427B2 (en) 1990-11-27

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