JPS54112872A - Preparation of dihydropyridine and pyridine derivatives - Google Patents
Preparation of dihydropyridine and pyridine derivativesInfo
- Publication number
- JPS54112872A JPS54112872A JP2014778A JP2014778A JPS54112872A JP S54112872 A JPS54112872 A JP S54112872A JP 2014778 A JP2014778 A JP 2014778A JP 2014778 A JP2014778 A JP 2014778A JP S54112872 A JPS54112872 A JP S54112872A
- Authority
- JP
- Japan
- Prior art keywords
- dihydropyridine
- trithiocyclopropenium
- salt
- amine
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
Abstract
PURPOSE: To prepare a dihydropyridine and pyridine derivatives useful as a raw material of pesticide, medicine, various chemicals, etc., easily and in high yield, by the reaction of trithiocyclopropenium salt with a specific amine.
CONSTITUTION: The dihydropyridine derivative III is prepared by reacting a trithiocyclopropenium salt I [R1 is (substituted) hydrocarbon, heterocyclic group; X- is anion) with an amine II (R2 is electron attractive substitution group; R3 is H, lower alkyl], e.g. β-aminopropionitrile, β-amino-n-butyronitrile, β-amino-n-propionic acid methyl ester, etc., in a solvent such as methylene chloride, at about room temperature. The amount of the amine is nearly equi-molar to the trithiocyclopropenium salt. The pyridine derivative IV can be obtained by the dehydrogenation of a derivative of the compound III.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2014778A JPS54112872A (en) | 1978-02-23 | 1978-02-23 | Preparation of dihydropyridine and pyridine derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2014778A JPS54112872A (en) | 1978-02-23 | 1978-02-23 | Preparation of dihydropyridine and pyridine derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS54112872A true JPS54112872A (en) | 1979-09-04 |
JPS5633389B2 JPS5633389B2 (en) | 1981-08-03 |
Family
ID=12019030
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014778A Granted JPS54112872A (en) | 1978-02-23 | 1978-02-23 | Preparation of dihydropyridine and pyridine derivatives |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54112872A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1101768C (en) * | 1998-12-14 | 2003-02-19 | 深圳三九药业有限公司 | Method and equipment for electrically dispensing Chinese medicines |
-
1978
- 1978-02-23 JP JP2014778A patent/JPS54112872A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1101768C (en) * | 1998-12-14 | 2003-02-19 | 深圳三九药业有限公司 | Method and equipment for electrically dispensing Chinese medicines |
Also Published As
Publication number | Publication date |
---|---|
JPS5633389B2 (en) | 1981-08-03 |
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