JPS5780370A - Alpha-methylcinnamic acid derivative, its preparation and antilipemic agent containing the same - Google Patents
Alpha-methylcinnamic acid derivative, its preparation and antilipemic agent containing the sameInfo
- Publication number
- JPS5780370A JPS5780370A JP15530780A JP15530780A JPS5780370A JP S5780370 A JPS5780370 A JP S5780370A JP 15530780 A JP15530780 A JP 15530780A JP 15530780 A JP15530780 A JP 15530780A JP S5780370 A JPS5780370 A JP S5780370A
- Authority
- JP
- Japan
- Prior art keywords
- acid derivative
- formula
- methylcinnamic acid
- alpha
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:An α-methylcinnamic acid derivative expressed by formula I (R is H or lower alkyl; n is an integer 0W3) or a salt thereof.
EXAMPLE: α-Methyl-p-( 2-pyridylmethyloxy )-cinnamic acid.
USE: An antilipemic agent, having the ability to reduce the concentrations of cholesterol and triglycerides in blood, and suitably administered in a dose of 200W500mg/day.
PROCESS: A pyridine derivative expressed by formula II (X is halogen) is reacted with a p-hydorxy-α-methylcinnamic acid derivative expressed by formula III in a suitable inert solvent in the presence of an alkali under heating and refluxing for 2W3hr to give the compound expressed by formula I.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15530780A JPS5780370A (en) | 1980-11-05 | 1980-11-05 | Alpha-methylcinnamic acid derivative, its preparation and antilipemic agent containing the same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15530780A JPS5780370A (en) | 1980-11-05 | 1980-11-05 | Alpha-methylcinnamic acid derivative, its preparation and antilipemic agent containing the same |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5780370A true JPS5780370A (en) | 1982-05-19 |
JPS6341392B2 JPS6341392B2 (en) | 1988-08-17 |
Family
ID=15603033
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15530780A Granted JPS5780370A (en) | 1980-11-05 | 1980-11-05 | Alpha-methylcinnamic acid derivative, its preparation and antilipemic agent containing the same |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5780370A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000001690A1 (en) * | 1998-07-03 | 2000-01-13 | Celltech Therapeutics Limited | Cinnamic acid derivatives as cell adhesion molecules |
US8465081B2 (en) | 2004-02-27 | 2013-06-18 | Magna Car Top Systems Gmbh | Convertible top cover and headliner interconnected by bows |
-
1980
- 1980-11-05 JP JP15530780A patent/JPS5780370A/en active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000001690A1 (en) * | 1998-07-03 | 2000-01-13 | Celltech Therapeutics Limited | Cinnamic acid derivatives as cell adhesion molecules |
US8465081B2 (en) | 2004-02-27 | 2013-06-18 | Magna Car Top Systems Gmbh | Convertible top cover and headliner interconnected by bows |
Also Published As
Publication number | Publication date |
---|---|
JPS6341392B2 (en) | 1988-08-17 |
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