JPS5780370A - Alpha-methylcinnamic acid derivative, its preparation and antilipemic agent containing the same - Google Patents

Alpha-methylcinnamic acid derivative, its preparation and antilipemic agent containing the same

Info

Publication number
JPS5780370A
JPS5780370A JP15530780A JP15530780A JPS5780370A JP S5780370 A JPS5780370 A JP S5780370A JP 15530780 A JP15530780 A JP 15530780A JP 15530780 A JP15530780 A JP 15530780A JP S5780370 A JPS5780370 A JP S5780370A
Authority
JP
Japan
Prior art keywords
acid derivative
formula
methylcinnamic acid
alpha
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15530780A
Other languages
Japanese (ja)
Other versions
JPS6341392B2 (en
Inventor
Tomio Ota
Yoshio Takahashi
Masami Takimoto
Masahiko Nagakura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KOUWA KK
Kowa Co Ltd
Original Assignee
KOUWA KK
Kowa Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KOUWA KK, Kowa Co Ltd filed Critical KOUWA KK
Priority to JP15530780A priority Critical patent/JPS5780370A/en
Publication of JPS5780370A publication Critical patent/JPS5780370A/en
Publication of JPS6341392B2 publication Critical patent/JPS6341392B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:An α-methylcinnamic acid derivative expressed by formula I (R is H or lower alkyl; n is an integer 0W3) or a salt thereof.
EXAMPLE: α-Methyl-p-( 2-pyridylmethyloxy )-cinnamic acid.
USE: An antilipemic agent, having the ability to reduce the concentrations of cholesterol and triglycerides in blood, and suitably administered in a dose of 200W500mg/day.
PROCESS: A pyridine derivative expressed by formula II (X is halogen) is reacted with a p-hydorxy-α-methylcinnamic acid derivative expressed by formula III in a suitable inert solvent in the presence of an alkali under heating and refluxing for 2W3hr to give the compound expressed by formula I.
COPYRIGHT: (C)1982,JPO&Japio
JP15530780A 1980-11-05 1980-11-05 Alpha-methylcinnamic acid derivative, its preparation and antilipemic agent containing the same Granted JPS5780370A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15530780A JPS5780370A (en) 1980-11-05 1980-11-05 Alpha-methylcinnamic acid derivative, its preparation and antilipemic agent containing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15530780A JPS5780370A (en) 1980-11-05 1980-11-05 Alpha-methylcinnamic acid derivative, its preparation and antilipemic agent containing the same

Publications (2)

Publication Number Publication Date
JPS5780370A true JPS5780370A (en) 1982-05-19
JPS6341392B2 JPS6341392B2 (en) 1988-08-17

Family

ID=15603033

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15530780A Granted JPS5780370A (en) 1980-11-05 1980-11-05 Alpha-methylcinnamic acid derivative, its preparation and antilipemic agent containing the same

Country Status (1)

Country Link
JP (1) JPS5780370A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000001690A1 (en) * 1998-07-03 2000-01-13 Celltech Therapeutics Limited Cinnamic acid derivatives as cell adhesion molecules
US8465081B2 (en) 2004-02-27 2013-06-18 Magna Car Top Systems Gmbh Convertible top cover and headliner interconnected by bows

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000001690A1 (en) * 1998-07-03 2000-01-13 Celltech Therapeutics Limited Cinnamic acid derivatives as cell adhesion molecules
US8465081B2 (en) 2004-02-27 2013-06-18 Magna Car Top Systems Gmbh Convertible top cover and headliner interconnected by bows

Also Published As

Publication number Publication date
JPS6341392B2 (en) 1988-08-17

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