IT1142649B - N 4 Phenyl 2 thiazolyl carbamate derivs. - Google Patents
N 4 Phenyl 2 thiazolyl carbamate derivs.Info
- Publication number
- IT1142649B IT1142649B IT25957/81A IT2595781A IT1142649B IT 1142649 B IT1142649 B IT 1142649B IT 25957/81 A IT25957/81 A IT 25957/81A IT 2595781 A IT2595781 A IT 2595781A IT 1142649 B IT1142649 B IT 1142649B
- Authority
- IT
- Italy
- Prior art keywords
- formula
- solvent
- phenyl
- thiazolyl
- cpds
- Prior art date
Links
- -1 Phenyl 2 thiazolyl carbamate Chemical compound 0.000 title abstract 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 6
- 239000002904 solvent Substances 0.000 abstract 4
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 abstract 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 abstract 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 abstract 1
- PYSJLPAOBIGQPK-UHFFFAOYSA-N 4-phenyl-1,3-thiazol-2-amine Chemical compound S1C(N)=NC(C=2C=CC=CC=2)=C1 PYSJLPAOBIGQPK-UHFFFAOYSA-N 0.000 abstract 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 230000036039 immunity Effects 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Landscapes
- Thiazole And Isothizaole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
N-(4-phenyl-2-thiazolyl) carbamate derivs. useful in immunity control prepns. for chronic articular rheumatism, viral diseases, cancer, etc. have formula (I), (where R1 = lower alkylthio, lower alkylsulphinyl, lower alkylsulphonyl, nitro or amino gp.; R2 = 1-4C lower alkyl or halogenated lower alkyl gp.). Cpds. (I) are prepd. either (1) by reacting 2-amino-4-phenyl thiazole of formula (II), (R1 as above), pref. dissolved in a solvent, e.g., benzene, tetrahydrofuran, etc., with a halogenated formic acid ester with the formula XCOOR2 (R2 as above; X = halogen atom) at room temp. or below or with heating to the solvent b.pt., or (2) by reacting alpha-halogenoacetophenone of formula (III), (R1, X as above) with thiourea with the formula NH2C(:S)NHCOOR2 (R2 as above), pref. with both cpds. dissolved in a solvent, e.g. dioxane, benzene, 1,2-dimethoxy ethane, for 1-6 hrs. at a temp. between room temp. and the solvent b.pt.
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP71481A JPS57116056A (en) | 1981-01-08 | 1981-01-08 | N-(4-phenyl-2-thiazolyl)carbamate derivative, its preparation and medicinal composition containing the same |
| JP213481A JPS57118573A (en) | 1981-01-12 | 1981-01-12 | N-(2-thiazolyl)carbamate derivative, its preparation, and drug composition comprising it |
| JP273981A JPS57118574A (en) | 1981-01-13 | 1981-01-13 | N-(4-phenylthiazol-2-yl)carbamate derivative, its preparation and medicinal composition containing the same |
| JP274081A JPS57118575A (en) | 1981-01-13 | 1981-01-13 | Disubstituted aminothiazole derivative, its preparation and medicinal composition |
| JP274181A JPS57118572A (en) | 1981-01-13 | 1981-01-13 | N-(4-phenyl-2-thiazolyl)amide derivative, its preparation, and drug composition comprising it |
| JP56006320A JPS57136579A (en) | 1981-01-21 | 1981-01-21 | Thiazolylurea derivative, its preparation, and pharmaceutical composition containing the same |
| JP632181A JPS57136578A (en) | 1981-01-21 | 1981-01-21 | Oxamide derivative, its preparation, and pharmaceutical composition containing the same |
| JP7352081A JPS57188578A (en) | 1981-05-18 | 1981-05-18 | N-(4-phenyl-2-thiazolyl)carbamic acid derivative and medicinal composition containing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT8125957A0 IT8125957A0 (en) | 1981-12-31 |
| IT1142649B true IT1142649B (en) | 1986-10-08 |
Family
ID=27571413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT25957/81A IT1142649B (en) | 1981-01-08 | 1981-12-31 | N 4 Phenyl 2 thiazolyl carbamate derivs. |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1142649B (en) |
-
1981
- 1981-12-31 IT IT25957/81A patent/IT1142649B/en active
Also Published As
| Publication number | Publication date |
|---|---|
| IT8125957A0 (en) | 1981-12-31 |
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