JPS5699483A - Preparation of pentoxifylline - Google Patents
Preparation of pentoxifyllineInfo
- Publication number
- JPS5699483A JPS5699483A JP228980A JP228980A JPS5699483A JP S5699483 A JPS5699483 A JP S5699483A JP 228980 A JP228980 A JP 228980A JP 228980 A JP228980 A JP 228980A JP S5699483 A JPS5699483 A JP S5699483A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- derivative
- compound
- blood
- organic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To prepare the titled compound effective to improve the blood flow, etc., easily, in high yield, by reacting a specific 3,7-dimethylxanthine derivative with a derivative of 5-oxohexanol.
CONSTITUTION: Pentoxifylline of formula IV is prepared by reacting (A) the quaternary ammonium salt or silyl derivative of 3,7-dimethylxanthine of formula I, i.e. a compound of formula II (R2 is lower alkyl) with (B) a 5-oxohexanol derivative of formula III (R1 is organic acid residue or organic sulfonic acid residue). Since the quaternary ammonium salt or the silyl derivative of the compound of formula I has high solubility in organic solvents, the reaction can be carried out in an organic solvent to prevent the isolation and precipitation of the compound of formula I produced in the presence of water, and consequently, to improve the yield.
USE: The compound increases the ATP content in erythrocyte, and improves the deformability of erythrocyte. It is also effective to inhibit the coagulation of blood platelet and to lower the viscosity of blood, and hence improves the fluidity of the blood.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP228980A JPS5699483A (en) | 1980-01-12 | 1980-01-12 | Preparation of pentoxifylline |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP228980A JPS5699483A (en) | 1980-01-12 | 1980-01-12 | Preparation of pentoxifylline |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5699483A true JPS5699483A (en) | 1981-08-10 |
Family
ID=11525206
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP228980A Pending JPS5699483A (en) | 1980-01-12 | 1980-01-12 | Preparation of pentoxifylline |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5699483A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112724160A (en) * | 2021-03-19 | 2021-04-30 | 赤峰经方医药技术开发有限责任公司 | Preparation method of pentoxifylline impurity |
-
1980
- 1980-01-12 JP JP228980A patent/JPS5699483A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112724160A (en) * | 2021-03-19 | 2021-04-30 | 赤峰经方医药技术开发有限责任公司 | Preparation method of pentoxifylline impurity |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS54148788A (en) | 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative and its preparation | |
JPS5699483A (en) | Preparation of pentoxifylline | |
JPS5780322A (en) | Cardiotonic agent | |
JPS5645460A (en) | Novel imidazolyl sulfonate derivative | |
JPS57146786A (en) | Optically active borane compound and preparation of optically active compound using the same | |
JPS57131719A (en) | Blood sugar level lowering agent | |
JPS57149221A (en) | Antiviral compound and antiviral agent | |
JPS56118006A (en) | Antifouling solution for fish net | |
JPS5671081A (en) | Thiazolinedicarboxylic acid derivative | |
JPS5569501A (en) | Herbicide | |
JPS5547651A (en) | Production of sulfoxyimine | |
JPS5545608A (en) | Preparation of organosilver compound | |
JPS55127366A (en) | Preparation of 4-(3-isopropylamino-2-hydroxypropoxy)-indole | |
JPS56161344A (en) | Preparation of 3-oxocyclopentene compound | |
JPS57212183A (en) | Preparation of xanthine derivative | |
JPS55129265A (en) | Interferon-inducing agent | |
JPS5455597A (en) | Preparation of theobromine derivative | |
JPS5581882A (en) | Preparation of hexahydronaphtho(1,2':4,5)imidazo(2,1-b)thiazole derivative | |
JPS5461192A (en) | Preparation of 1-(5-oxohexyl)theobromine | |
JPS54119448A (en) | Preparaton of beta-lactam compound | |
JPS5461193A (en) | Preparation of 1-(5-oxohexyl)theobromine | |
JPS5543481A (en) | Detection agent | |
JPS5687584A (en) | Preparation of 7-methoxycephem compound | |
JPS572271A (en) | Preparation of 2-aminoindolenine derivative | |
SE8400451L (en) | SOURCE EXTENSION AZAPINOL (1-2-A) PYRIMIDINE DERIVATIVES AND ACID ADDITION SALTS THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |