JPS5699483A - Preparation of pentoxifylline - Google Patents

Preparation of pentoxifylline

Info

Publication number
JPS5699483A
JPS5699483A JP228980A JP228980A JPS5699483A JP S5699483 A JPS5699483 A JP S5699483A JP 228980 A JP228980 A JP 228980A JP 228980 A JP228980 A JP 228980A JP S5699483 A JPS5699483 A JP S5699483A
Authority
JP
Japan
Prior art keywords
formula
derivative
compound
blood
organic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP228980A
Other languages
Japanese (ja)
Inventor
Kazuo Satoie
Hiromitsu Saito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TOHO IYAKU KENKYUSHO KK
Original Assignee
TOHO IYAKU KENKYUSHO KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TOHO IYAKU KENKYUSHO KK filed Critical TOHO IYAKU KENKYUSHO KK
Priority to JP228980A priority Critical patent/JPS5699483A/en
Publication of JPS5699483A publication Critical patent/JPS5699483A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To prepare the titled compound effective to improve the blood flow, etc., easily, in high yield, by reacting a specific 3,7-dimethylxanthine derivative with a derivative of 5-oxohexanol.
CONSTITUTION: Pentoxifylline of formula IV is prepared by reacting (A) the quaternary ammonium salt or silyl derivative of 3,7-dimethylxanthine of formula I, i.e. a compound of formula II (R2 is lower alkyl) with (B) a 5-oxohexanol derivative of formula III (R1 is organic acid residue or organic sulfonic acid residue). Since the quaternary ammonium salt or the silyl derivative of the compound of formula I has high solubility in organic solvents, the reaction can be carried out in an organic solvent to prevent the isolation and precipitation of the compound of formula I produced in the presence of water, and consequently, to improve the yield.
USE: The compound increases the ATP content in erythrocyte, and improves the deformability of erythrocyte. It is also effective to inhibit the coagulation of blood platelet and to lower the viscosity of blood, and hence improves the fluidity of the blood.
COPYRIGHT: (C)1981,JPO&Japio
JP228980A 1980-01-12 1980-01-12 Preparation of pentoxifylline Pending JPS5699483A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP228980A JPS5699483A (en) 1980-01-12 1980-01-12 Preparation of pentoxifylline

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP228980A JPS5699483A (en) 1980-01-12 1980-01-12 Preparation of pentoxifylline

Publications (1)

Publication Number Publication Date
JPS5699483A true JPS5699483A (en) 1981-08-10

Family

ID=11525206

Family Applications (1)

Application Number Title Priority Date Filing Date
JP228980A Pending JPS5699483A (en) 1980-01-12 1980-01-12 Preparation of pentoxifylline

Country Status (1)

Country Link
JP (1) JPS5699483A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112724160A (en) * 2021-03-19 2021-04-30 赤峰经方医药技术开发有限责任公司 Preparation method of pentoxifylline impurity

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112724160A (en) * 2021-03-19 2021-04-30 赤峰经方医药技术开发有限责任公司 Preparation method of pentoxifylline impurity

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